Navigation Links
Research Reveals How Down Syndrome Shields Against Cancer
Date:5/20/2009

m, a cancer researcher with the Children's Vascular Biology Program at Children's Hospital, Boston. "That's not true now. Many medical issues [for people with Down syndrome] are treatable and correctable, and they now live long enough. And we still find significant protection against solid-tumor cancers."

This study builds on the work of U.S. angiogenesis pioneer Dr. Judah Folkman, who died last year. Angiogenesis refers to the growth of blood vessels necessary to nourish cancer cells. Folkman hypothesized that angiogenesis inhibition might be key to preventing cancers from forming.

Folkman's initial theory stemmed partly from the observation that people with Down syndrome also suffered fewer angiogenesis-related diseases such as diabetic retinopathy, atherosclerosis and the eye disease macular degeneration.

These researchers zeroed in on the Dscr1 (Down syndrome candidate region-1) gene, which dampens the growth of blood vessels by inhibiting a chemical called vascular endothelial growth factor.

The gene's activity is elevated in mouse models of Down syndrome and in human Down syndrome tissue. This elevation in activity is enough to suppress tumors, although it doesn't explain the extent of the cancer-protective effect seen in individuals with Down's, the researchers said.

"This suggests that Dscr1 is incredibly important in blocking tumor growth, and the reason the tumors grow slowly is that blood vessel formation was blocked," Ryeom said. "This told us that Dscr1 played a critical role in suppressing tumor angiogenesis."

Dscr1 alone resulted in some tumor suppression but there may be as many as five genes involved in the action. "Dscr1 is necessary but not sufficient," Ryeom explained.

In fact, Ryeom and her colleagues believe that Dscr1 works with another gene on chromosome 21, called Dyrk1a, to block what's known as the "calcineurin-signaling pathway" -- a circuit involved in helping tu
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. PIPC Supports New Comparative Effectiveness Research (CER) Bill
2. CSI: Mayo Clinic Researchers Find Television Shows Inaccurately Portray Violent Crime
3. Prestigious award for outstanding primary-care researcher
4. University of Haifa research team awarded European Union research grant
5. Peter MacCallum Cancer Centre Expands Cancer Research Efforts with Automation Tool from Caliper Life Sciences
6. Research reveals molecular pathway behind invasive prostate cancers
7. Mayo Clinic Researchers Say Triple Drug Combination is Promising Option to Treat Metastatic HER2+ Breast Cancer
8. Two Targeted Therapies Likely Better Than One in Patients with Aggressive Lymphoma, Mayo Clinic Researchers Say
9. Mayo Clinic Researchers Say Agent Provides Treatment Option for Women with Hot Flashes
10. Drug That Targets Vasculature Growth Attacks Aggressive Thyroid Cancer, Mayo Clinic Researchers Report
11. $1.5 million awarded for palliative care research to improve care of seriously ill patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research Reveals How Down Syndrome Shields Against Cancer
(Date:7/25/2014)... July 25, 2014 Eye & Vision ... at their office location by expanding a new specialized ... kind comprehensive visual electro-physiology clinic. , By acquiring specialized ... of experience in vision problems, patients with vision loss ... take advantage of the implementation of this specialized vision ...
(Date:7/25/2014)... 2014 The European liquid chromatography reagents ... with analysis and forecast of revenue. The liquid chromatography ... million in 2013, and is estimated to grow to ... 9.4 %, from 2013 to 2018. , Browse through ... to get an idea of the in-depth analysis provided. ...
(Date:7/25/2014)... genes may play a greater role in language delay ... Researchers found more evidence that language traits, such ... inherited. The study involving 473 sets of twins ... language performance for twins than single-born children) was greater ... disputes hypotheses that attribute delays in early language acquisition ...
(Date:7/25/2014)... are switched on or off plays a key role ... UT Southwestern Medical Center researchers have found., The research ... and diabetes, since the transcription factor involved spliced ... the body,s sensitivity to insulin and leptin signaling. Insulin ... of food intake and sugar disposal, and obesity and ...
(Date:7/25/2014)... The American Brain Tumor Association (ABTA) announced today ... Distinguished Events, and Corporate and Special Events Manager - ... be joining the ABTA in the newly created position ... roll out of a nationwide brain tumor volunteer effort ... volunteer network will provide the Chicago-based ABTA with a ...
Breaking Medicine News(10 mins):Health News:Eye & Vision, a Leading Eye Doctor Group in Richardson, Celebrate Milestone and Expand Scope of Specialized Eye Care 2Health News:Eye & Vision, a Leading Eye Doctor Group in Richardson, Celebrate Milestone and Expand Scope of Specialized Eye Care 3Health News:European Liquid Chromatography Reagents Market is Expected to Reach $1581.8 Million in 2018 - New Report by MicroMarket Monitor 2Health News:European Liquid Chromatography Reagents Market is Expected to Reach $1581.8 Million in 2018 - New Report by MicroMarket Monitor 3Health News:European Liquid Chromatography Reagents Market is Expected to Reach $1581.8 Million in 2018 - New Report by MicroMarket Monitor 4Health News:Genes May Be Key to Language Delay in Kids 2Health News:Manipulating key protein in the brain holds potential against obesity and diabetes 2Health News:American Brain Tumor Association Recruits Director to Lead New Volunteer Network 2
... and efficacy of first FDA-approved nebulized ... COPD -, NAPA, Calif., May 16 Dey, ... given at the International,Conference of the American Thoracic Society ... Center. One of the presentations details the,effects on dyspnea ...
... mastectomy (total breast removal) for early-stage breast cancer has ... in Rochester. The increase follows a steady decline during ... for this increase are unclear. But they have determined ... resonance imaging (MRI) prior to surgery to treat early-stage ...
... sooner if therapy is working , , FRIDAY, May 16 ... levels of circulating tumor cells can help doctors more ... with metastatic breast cancer, according to a Georgetown University ... weeks, and sometimes months, to determine if a particular ...
... /Xinhua-PRNewswire-FirstCall/ --,Shengtai Pharmaceutical, Inc. (OTC Bulletin Board: SGTI) ... distributor,of high-quality, pharmaceutical grade glucose products in China, ... March 31, 2008., Third Quarter of ... to $20.7 million -- Gross profit rose ...
... May 16 IDM Pharma, Inc.,(Nasdaq: IDMI ... Company,s lead product candidates will be made at ... annual meeting. Data presented,at the meeting will support ... L-MTP-PE, as well as patients with non-small lung,cancer ...
... wake of divorce, illness, violence and other problems that ... experience temporary separations from one or both parents before ... May/June issue of Ambulatory Pediatrics, a new, community-wide study ... at increased risk for learning difficulties and that these ...
Cached Medicine News:Health News:Clinical Trial Data for Perforomist(TM) Inhalation Solution to be Presented at ATS on May 20, 2008 2Health News:Clinical Trial Data for Perforomist(TM) Inhalation Solution to be Presented at ATS on May 20, 2008 3Health News:Clinical Trial Data for Perforomist(TM) Inhalation Solution to be Presented at ATS on May 20, 2008 4Health News:Clinical Trial Data for Perforomist(TM) Inhalation Solution to be Presented at ATS on May 20, 2008 5Health News: Mastectomies on the rise and MRI use may explain part of the trend, say Mayo researchers 2Health News: Mastectomies on the rise and MRI use may explain part of the trend, say Mayo researchers 3Health News:Blood Test Helps Docs Assess Breast Cancer Treatment 2Health News:Shengtai Pharmaceutical, Inc. Reports Third Quarter Results of Fiscal Year 2008 2Health News:Shengtai Pharmaceutical, Inc. Reports Third Quarter Results of Fiscal Year 2008 3Health News:Shengtai Pharmaceutical, Inc. Reports Third Quarter Results of Fiscal Year 2008 4Health News:Shengtai Pharmaceutical, Inc. Reports Third Quarter Results of Fiscal Year 2008 5Health News:Shengtai Pharmaceutical, Inc. Reports Third Quarter Results of Fiscal Year 2008 6Health News:Shengtai Pharmaceutical, Inc. Reports Third Quarter Results of Fiscal Year 2008 7Health News:Shengtai Pharmaceutical, Inc. Reports Third Quarter Results of Fiscal Year 2008 8Health News:Shengtai Pharmaceutical, Inc. Reports Third Quarter Results of Fiscal Year 2008 9Health News:Shengtai Pharmaceutical, Inc. Reports Third Quarter Results of Fiscal Year 2008 10Health News:Shengtai Pharmaceutical, Inc. Reports Third Quarter Results of Fiscal Year 2008 11Health News:Shengtai Pharmaceutical, Inc. Reports Third Quarter Results of Fiscal Year 2008 12Health News:IDM Pharma Announces Presentations at 44th American Society of Clinical Oncology Annual Meeting 2Health News:IDM Pharma Announces Presentations at 44th American Society of Clinical Oncology Annual Meeting 3Health News:Separation from mom, dad linked with learning trouble in kids 2Health News:Separation from mom, dad linked with learning trouble in kids 3
(Date:7/24/2014)... MOUNTAIN VIEW, Calif. , July 24, 2014 ... ), a leading provider of medication and supply ... hold a conference call Thursday, July 31, to ... What:  , Omnicell Second Quarter 2014 earnings ... 2014, 1:30 p.m. PTWho:  , Randall Lipps, chairman, ...
(Date:7/24/2014)... MENLO PARK, Calif. , July 24, 2014 ... "the company") announced today that the company,s board of directors ... 31 to June 30. Accordingly, DelMar will file a Transition ... Jeffrey Bacha , president and CEO of DelMar stated, ... in achieving our goal of obtaining a senior exchange listing ...
(Date:7/24/2014)... 24, 2014 LSI Medience Corporation today ... with Kineticos, a Raleigh-Durham, NC ... support LSI Medience in identifying opportunities for Presepsin, ... utility in clinical trials. The Presepsin ... diagnosis of sepsis, prognosis of septic patients, early ...
Breaking Medicine Technology:Omnicell to Release Second Quarter 2014 Earnings Results on July 31 2DelMar Pharmaceuticals Announces Change of Fiscal Year End and Provides Update on Glioblastoma Clinical Trial 2DelMar Pharmaceuticals Announces Change of Fiscal Year End and Provides Update on Glioblastoma Clinical Trial 3LSI Medience Corporation and Kineticos Sign Agreement Related to the Presepsin Biomarker in Sepsis Management and Treatment 2
... Pharmaceuticals, Inc. (NASDAQ: REGN ) today announced that ... 2012 at 8:30 a.m. Eastern Time to provide an update ... Inc., a member of the Roche Group (SIX: RO, ROG; ... (888) 660-6127 International Dial-in Number: (973) 890-8355 Participant Code:  40392582 ...
... SINGAPORE, Dec. 30, 2011 /PRNewswire-Asia/ -- Biosensors International Group, ... SGX: B20), a developer, manufacturer and marketer of innovative ... today announced it will be participating in the 30th ... from 9th to 12th January 2012 in San Francisco, ...
Cached Medicine Technology:Regeneron to Host Conference Call on January 3 at 8:30 a.m. Eastern Time to Discuss Ongoing Patent Litigation 2Biosensors International to Participate in the 30th Annual J.P. Morgan Healthcare Conference 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: