Navigation Links
Research Reveals How Breast Cancer Rearranges Genome

Disease plays havoc with DNA sequence, study finds

THURSDAY, Dec. 24 (HealthDay News) -- An analysis of breast cancer genomes has provided insight into how the human genome is rearranged when the disease strikes, researchers report.

"We have looked at the level of the DNA sequence at just how splintered and reorganized the genome is in many breast cancers. We were, frankly, astounded at the number and complexity of rearrangements in some cancers," Mike Stratton of the Wellcome Trust Sanger Institute in Cambridge, U.K., said in a news release from the institute.

"Just as important, the genomes were different from each other, with multiple distinctive patterns of rearrangement observed, supporting the view that breast cancer is not one, but several diseases," Stratton added.

According to the researchers, who looked at 24 breast cancer samples, the study findings will help doctors do a better job of classifying tumors, which will improve the diagnosis and treatment of breast cancer.

"It looks as though some breast cancers have a defect in the machinery that maintains and repairs DNA, and this defect is resulting in large numbers of these abnormalities," said the institute's Dr. Andy Futreal, in the news release. "At the moment, we do not know what the defect is or the abnormal gene underlying it, but we are seeing the result of its malfunction in the hideously untidy state of these genomes. Identifying the underlying mutated cause will be central to working out how some breast cancers develop."

The study findings are published online Dec. 23 in the journal Nature.

More information

The U.S. National Cancer Institute has more about breast cancer.

-- Randy Dotinga

SOURCE: Wellcome Trust Sanger Institute, news release, Dec. 23, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Researchers find new patterns in H1N1 deaths
2. Hard to treat Diseases (HTDS) To Sell Its MindUp BioResearch Division
3. Pot and pop: New research finds stronger link between music and marijuana use among teens
4. National MS Society Continues to Propel Research Forward to End MS - Launches 2010 With Call for Research Grants to Pursue CCSVI Leads
5. Lung Cancer Foundation of America Gives the Gift of Life This Holiday Season: Announces Inaugural $125,000 Scientific Research Grant
6. Researchers discover gene therapy to prevent progression of emphysema
7. Orameds Dr Roy Eldor was Chosen to Lecture at the First International Conference Held by the Bildirici Center for Diabetes Care Research in Israel.
8. Exposing the Double Standard of the Forgotten Cancer: Biggest Cancer Killer for Women and Men, Lung Cancer, Receives Least Research Funds
9. Lung Cancer Alliance Hails New Federal Funding for Lung Cancer Research
10. IBS Treatment Center Calls on McCain to Support IBS Research
11. Researchers at the John Theurer Cancer Center Present Cutting-Edge Research Results at this Years American Society of Hematology Annual Meeting
Post Your Comments:
(Date:6/27/2016)... ... 27, 2016 , ... "FCPX editors can now reveal their media with growing ... said Christina Austin - CEO of Pixel Film Studios. , ProSlice Color brings ... users can now reveal the media of their split screens with growing colorful panels. ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, ... remain in the eye of the beholder, according to experts who offered insights and ... Journal of Managed Care. For the full issue, click here . , For ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are confused ... endometriosis. These women need a treatment plan to not only alleviate symptoms and ... help for preservation of fertility and ultimately achieving a pregnancy. The specialists at ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... ... the United States, named Dr. Sesan Ogunleye, as the Medical Director of its new ... the facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... The Academy of Managed Care Pharmacy (AMCP) ... would allow biopharmaceutical companies to more easily share health ... and coverage decisions, a move that addresses the growing ... The recommendations address restrictions in the sharing of ... label, a prohibition that hinders decision makers from accessing ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
Breaking Medicine Technology: