Navigation Links
Research Reveals Clues to Breast Cancer's Spread
Date:7/6/2009

Interrupting key signals might prevent recurrence, investigators say

MONDAY, July 6 (HealthDay News) -- A U.S. research team says it has spotted key signals that help breast cancer cells survive in the bone marrow of patients who've undergone treatment.

The finding, reported in the July issue of the journal Cancer Cell, could lead to new treatments to prevent breast cancer's return, according to the researchers.

"We sought to identify signaling pathways that support the survival of metastasized breast cancer cells and thereby extend the period during which metastasis may emerge after the diagnosis and removal of a breast tumor," senior study author Dr. Joan Massague, of the cancer biology and genetics programs at Memorial Sloan-Kettering Cancer Center and the Howard Hughes Medical Institute, explained in a journal news release.

The researchers analyzed samples from more than 600 breast tumors and found that a cancer-related enzyme called Src was associated with late-onset bone metastasis. This link was independent of breast cancer subtype and was selective and specific for breast cancer cell survival in bone marrow.

Massague and colleagues then identified Src-regulated signaling molecules that were expressed in bone marrow and promoted survival of breast cancer cells. They also found that Src increased resistance to a key cell death-inducing signal.

The findings provides insights into breast cancer's spread, "and suggests strategies to hasten the attrition of disseminated breast cancer cells," the researchers concluded. They also noted that drugs designed to inhibit Src have recently been developed "that may be worthy of consideration" to help fight tumor recurrence.

More information

Breastcancer.org has more about recurrent and metastatic breast cancer.



-- Robert Preidt



SOURCE: Cell Press, news release, July 6, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Moles and melanoma -- researchers find genetic links to skin cancer
2. Australian researchers identify genes that cause melanoma
3. Toronto researchers discovery points to a new treatment avenue for acute myeloid leukemia
4. American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting
5. Researchers find possible environmental causes for Alzheimers, diabetes
6. Online Voting Begins for Ford Customer Service Divisions Second Annual Funny Car Design Contest to Support Juvenile Diabetes Research Foundation
7. Research output in developing countries reveals 194 percent increase in five years
8. Liverpool to strengthen health research in Africa
9. Grant received for eye disorder research
10. Successful Beginning for Wellstone Muscular Dystrophy Center at Boston Biomedical Research Institute
11. International Collaboration led by Dr. Pablo V. Gejman,Researcher At NorthShore University HealthSystem's Research Institute, Finds Genetic Association of Schizophrenia to Chromosome 6p Variant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research Reveals Clues to Breast Cancer's Spread
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the largest ... as the Medical Director of its new Mesquite-Samuell Farm facility. , “We are ... Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Comfort ... the American Cancer Society and the Road To Recovery® program to drive cancer patients ... seniors and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... NY (PRWEB) , ... June 24, 2016 , ... ... Haute Living, is proud to recognize Dr. Barry M. Weintraub as a prominent ... “the most beautiful women in the world, and the most handsome men, look ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 26, 2016 Story ... operating models within the health care industry is causing ... efficiency , Deloitte offers a suite of solutions ... issues impacting efficient cost optimization: labor resource analysis, revenue ... services facilitate better outcomes and better economics ...
(Date:6/24/2016)... 2016 Dublin ... addition of the " Global Markets for Spectroscopy ... This report focuses on the ... review, including its applications in various applications. The report ... includes three main industries: pharmaceutical and biotechnology, food and ...
(Date:6/24/2016)... , June 24, 2016 Research and ... Market for Companion Diagnostic Tests" report to their offering. ... for Companion Diagnostics The World Market for ... personalized medicine diagnostics. Market analysis in the report includes the ... Market (In Vitro Diagnostic Kits) by Region (N. America, EU, ...
Breaking Medicine Technology: