Navigation Links
Research Reveals Clues to Breast Cancer's Spread
Date:7/6/2009

Interrupting key signals might prevent recurrence, investigators say

MONDAY, July 6 (HealthDay News) -- A U.S. research team says it has spotted key signals that help breast cancer cells survive in the bone marrow of patients who've undergone treatment.

The finding, reported in the July issue of the journal Cancer Cell, could lead to new treatments to prevent breast cancer's return, according to the researchers.

"We sought to identify signaling pathways that support the survival of metastasized breast cancer cells and thereby extend the period during which metastasis may emerge after the diagnosis and removal of a breast tumor," senior study author Dr. Joan Massague, of the cancer biology and genetics programs at Memorial Sloan-Kettering Cancer Center and the Howard Hughes Medical Institute, explained in a journal news release.

The researchers analyzed samples from more than 600 breast tumors and found that a cancer-related enzyme called Src was associated with late-onset bone metastasis. This link was independent of breast cancer subtype and was selective and specific for breast cancer cell survival in bone marrow.

Massague and colleagues then identified Src-regulated signaling molecules that were expressed in bone marrow and promoted survival of breast cancer cells. They also found that Src increased resistance to a key cell death-inducing signal.

The findings provides insights into breast cancer's spread, "and suggests strategies to hasten the attrition of disseminated breast cancer cells," the researchers concluded. They also noted that drugs designed to inhibit Src have recently been developed "that may be worthy of consideration" to help fight tumor recurrence.

More information

Breastcancer.org has more about recurrent and metastatic breast cancer.



-- Robert Preidt



SOURCE: Cell Press, news release, July 6, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Moles and melanoma -- researchers find genetic links to skin cancer
2. Australian researchers identify genes that cause melanoma
3. Toronto researchers discovery points to a new treatment avenue for acute myeloid leukemia
4. American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting
5. Researchers find possible environmental causes for Alzheimers, diabetes
6. Online Voting Begins for Ford Customer Service Divisions Second Annual Funny Car Design Contest to Support Juvenile Diabetes Research Foundation
7. Research output in developing countries reveals 194 percent increase in five years
8. Liverpool to strengthen health research in Africa
9. Grant received for eye disorder research
10. Successful Beginning for Wellstone Muscular Dystrophy Center at Boston Biomedical Research Institute
11. International Collaboration led by Dr. Pablo V. Gejman,Researcher At NorthShore University HealthSystem's Research Institute, Finds Genetic Association of Schizophrenia to Chromosome 6p Variant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research Reveals Clues to Breast Cancer's Spread
(Date:3/27/2017)... , ... March 27, 2017 , ... ... today announced it will co-exhibit with technology partners LG Business Solutions at ... Marriott Metro Center in Washington D.C., will provide education and examination into the ...
(Date:3/27/2017)... ... March 27, 2017 , ... ... the CE Certificate of Conformity for the Smart System® 20/20. CE Certification builds ... highest industry standards and specifications such as ANSI, ISO and proven test methods ...
(Date:3/27/2017)... , ... March 27, 2017 , ... ... quickly sideline athletes. A type of groin injury, it occurs when the muscles ... serious, intense pain in and around the lower torso, as well as accompanying ...
(Date:3/27/2017)... ... March 27, 2017 , ... EpiGentek , a ... the recent RNA methylation “gold rush” with their established portfolio of optimized assay ... of N6-methyladenosine, or m6A , RNA methylation has received a new burst ...
(Date:3/27/2017)... San Mateo, CA (PRWEB) , ... March 27, 2017 , ... Janet Schloz is still ... one of the best days I’ve had in a long time,” she said. , She ... a lot of money that I never thought I would have to help my students.” ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... , March 27, 2017 ... better understand Bayer and its partnering interests and activities since ... report provides an in-depth insight into the partnering activity of ... On demand company reports are prepared upon purchase to ensure ... data. The report will be delivered in PDF ...
(Date:3/27/2017)... -- Cryoport, Inc. (NASDAQ: CYRX, CYRXW) ("Cryoport" or the "Company") ... common stock in an underwritten public offering under an ... and Exchange Commission (the "SEC"). The offering is subject ... no assurance as to whether or when the offering ... or terms of the offering. Cryoport also expects to ...
(Date:3/27/2017)... 2017  A new survey from the ... Competitive Bidding Program (CBP) significantly reduced beneficiary choice and ... of choice forces beneficiaries to switch to unfamiliar or ... AADE,s survey is the latest in ... pointing out the inherent problems with the CBP. Last ...
Breaking Medicine Technology: