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Research Reveals Cancer Drug Effectiveness Substantially Advanced
Date:4/8/2010

and could possibly be used to treat most, if not all, solid tumors. The iRGD peptide was also shown to enhance the therapeutic effects of multiple types of anti-cancer drugs, including a small molecule drug, a monoclonal antibody and two nanoparticle drugs. Tumors essentially resistant to a particular drug showed good responses when the drug was combined with iRGD, and tumors partially responsive to another drug were eradicated by the combination.

“We are really excited about the potential of iRGD, and I’d like to thank my colleagues, Kazuki Sugahara and Tambet Teesalu in particular, who made this all happen,” said Dr. Ruoslahti. “These results with human tumors in mice are very promising, but we still have to demonstrate the value of iRGD in treating cancers in humans.”

The Science paper “Co-administration of a Tumor-Penetrating Peptide Enhances the
Efficacy of Cancer Drugs” will be available at http://sciencemag.org after 5:00 PM EST

A video interview with Professor Ruoslahti is available at http://vimeo.com/10780518

Animation of the science is available at http://www.sanfordburnham.org/movies/ER_Animation_MOV.mov

A high-resolution image of the illustration is available at http://www.sanfordburnham.org/img/ER_Vers_Three-8.5x11_300ppi.jpg

About Sanford-Burnham Medical Research Institute
Sanford-Burnham Medical Research Institute (formerly Burnham Institute for Medical Research) is dedicated to discovering the fundamental molecular c
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