Navigation Links
Research May Yield New Weapons Against Sepsis
Date:2/27/2008

The severe blood infection kills more than 33,000 Americans per year, experts say

WEDNESDAY, Feb. 27 (HealthDay News) -- U.S. researchers say they've spotted several potential new drug targets for the serious blood infection known as sepsis.

Sepsis, caused by a bacterial infection that enters the bloodstream, is a severe, difficult-to-treat, and often fatal condition that kills tens of thousands of Americans a year.

In their research in mice, a team at the Scripps Institute in La Jolla, Calif., discovered an important connection between blood coagulation and the immune system.

The study was published in the Feb. 27 online issue of the journal Nature.

"We have identified a key connection of signaling pathways in the cascade of events leading to sepsis. This defines a crucial point where the immune system spirals out of control to cause severe sepsis and where there is an opportunity for therapeutic intervention," research co-leader Wolfram Ruf, a professor in the department of immunology, said in a prepared statement.

In this study, the Scripps team described its discovery of a new cross-talk mechanism involving the vascular coagulation system and certain cells in the immune system. When the researchers disrupted this cross-talk, they saved the lives of mice with sepsis.

These successful proof-of-principle experiments may help improve the diagnosis of various sepsis syndromes and lead to the development of new drugs to treat sepsis, the researchers said.

The Scripps team is now evaluating which targets would be the best candidates for drug therapy and is also looking at this pathway's potential role in other infectious diseases.

Sepsis, one of the leading causes of death among infants and adults in the United States, killed more than 33,000 people in 2004, according to the Centers for Disease Control and Prevention.

A number of therapies, including antibiotics, have been used to treat sepsis over the years, but they have a number of drawbacks.

More information

The Society of Critical Care Medicine has more about sepsis.



-- Robert Preidt



SOURCE: Scripps Research Institute, news release, Feb. 27, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. U of Minn researchers find primary alcohol prevention programs are needed for tweens
2. Researchers collaborate to find new vaccine technology decreases E. coli in beef cattle
3. Jan Marini Skin Research Introduces Age Intervention(R) Transitions - a New Frontier in Skin Care
4. Efforts to Recruit, Retain and Research Nations Social Workers Gain Bipartisan Support in Congress
5. Abbott, Genentech and WEHI Collaborate to Research and Develop New Anti-Cancer Drugs
6. AMA Foundation Announces Seed Grant Research Recipients
7. The Low-Fat Diet is Fueling Our Rate of Obesity, Says Researcher Phoenix Gilman
8. NIH awards OHSU researcher $1.2 million to determine causes of, risk factors for pelvic floor injury
9. Researchers identify and shut down protein that fuels ovarian cancer
10. Implementers, Advocates, Researchers Call on Congress to Honor Lantos Commitment to Public Health and Human Rights by Placing Evidence over Ideology
11. Penn researchers engineer first system of human nerve-cell tissue
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research May Yield New Weapons Against Sepsis
(Date:10/13/2017)... , ... October 13, 2017 , ... Ellevate Network, the ... business to advocate for action towards gender equality at their inaugural Summit in New ... the globe, and reached a social audience of over 3 million. To watch the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in ... awarded a contract by the Center for Medicare and Medicaid Services (CMS). The ... enterprise use of Agile methodologies in a consistent and high value manner across ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical ... Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. ... honor of Morris F. Collen, a pioneer in the field of medical informatics, this ...
(Date:10/12/2017)... ... , ... HMP , a leader in healthcare events and education, today announced ... Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & Ozzie ... competition recognizes editorial and design excellence across a range of sectors. This year’s program ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., a ... design, and immune-engineering today announced the launch of ... development of personalized therapeutic cancer vaccines. EpiVax has ... exclusive access to enabling technologies to the new ... will lead EpiVax Oncology as Chief Executive Officer. ...
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
(Date:9/19/2017)... a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses pulsed ...   ... Jim Bertolina, ... Tom Tefft ... medical device executive Josh Stopek , PhD, who has led R&D and business development ...
Breaking Medicine Technology: