Navigation Links
Research May Yield New Weapons Against Sepsis
Date:2/27/2008

The severe blood infection kills more than 33,000 Americans per year, experts say

WEDNESDAY, Feb. 27 (HealthDay News) -- U.S. researchers say they've spotted several potential new drug targets for the serious blood infection known as sepsis.

Sepsis, caused by a bacterial infection that enters the bloodstream, is a severe, difficult-to-treat, and often fatal condition that kills tens of thousands of Americans a year.

In their research in mice, a team at the Scripps Institute in La Jolla, Calif., discovered an important connection between blood coagulation and the immune system.

The study was published in the Feb. 27 online issue of the journal Nature.

"We have identified a key connection of signaling pathways in the cascade of events leading to sepsis. This defines a crucial point where the immune system spirals out of control to cause severe sepsis and where there is an opportunity for therapeutic intervention," research co-leader Wolfram Ruf, a professor in the department of immunology, said in a prepared statement.

In this study, the Scripps team described its discovery of a new cross-talk mechanism involving the vascular coagulation system and certain cells in the immune system. When the researchers disrupted this cross-talk, they saved the lives of mice with sepsis.

These successful proof-of-principle experiments may help improve the diagnosis of various sepsis syndromes and lead to the development of new drugs to treat sepsis, the researchers said.

The Scripps team is now evaluating which targets would be the best candidates for drug therapy and is also looking at this pathway's potential role in other infectious diseases.

Sepsis, one of the leading causes of death among infants and adults in the United States, killed more than 33,000 people in 2004, according to the Centers for Disease Control and Prevention.

A number of therapies, including antibiotics, have been used to treat sepsis over the years, but they have a number of drawbacks.

More information

The Society of Critical Care Medicine has more about sepsis.



-- Robert Preidt



SOURCE: Scripps Research Institute, news release, Feb. 27, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. U of Minn researchers find primary alcohol prevention programs are needed for tweens
2. Researchers collaborate to find new vaccine technology decreases E. coli in beef cattle
3. Jan Marini Skin Research Introduces Age Intervention(R) Transitions - a New Frontier in Skin Care
4. Efforts to Recruit, Retain and Research Nations Social Workers Gain Bipartisan Support in Congress
5. Abbott, Genentech and WEHI Collaborate to Research and Develop New Anti-Cancer Drugs
6. AMA Foundation Announces Seed Grant Research Recipients
7. The Low-Fat Diet is Fueling Our Rate of Obesity, Says Researcher Phoenix Gilman
8. NIH awards OHSU researcher $1.2 million to determine causes of, risk factors for pelvic floor injury
9. Researchers identify and shut down protein that fuels ovarian cancer
10. Implementers, Advocates, Researchers Call on Congress to Honor Lantos Commitment to Public Health and Human Rights by Placing Evidence over Ideology
11. Penn researchers engineer first system of human nerve-cell tissue
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research May Yield New Weapons Against Sepsis
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, ... Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. ... skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was ...
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... are unfamiliar with. The article goes on to state that individuals are now more ... these less common operations such as calf and cheek reduction. The Los Angeles area ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Conference and Scientific Sessions in Dallas that it will receive two significant new ... the grants came as PHA marked its 25th anniversary by recognizing patients, medical ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and ... that call for a minimum wage raise to $12 an hour by 2020 and then ... will restore the lost value of the minimum wage, assure the wage floor does not ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that it ... (procalcitonin) assay as a dedicated testing solution for people ... Roche is the first IVD company in the U.S ... assessment and management. PCT is a sepsis-specific ... blood can aid clinicians in assessing the risk of ...
(Date:6/23/2016)... , , , WHEN: , , ... , , , LOCATION: , , , Online, with free registration ... PANELISTS:  , , , Frost & Sullivan,s Global Vice President of ... Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... witnessing an exceptional era. Several new demand spaces, such as innovative ...
Breaking Medicine Technology: