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Research Identifies Predictors for Successful IVF
Date:11/10/2008

to cycles using FSH alone," added Dr. Korner.

Once-Daily vs. Twice-Daily Dosing in Mixed Stimulation Protocols

Two studies compared once with twice daily gonadotropin dosing, using both hMG (MENOPUR) and FSH (BRAVELLE). Results of a prospective randomized study of 87 patients showed that once-daily dosing, administered as a single combined gonadotropin injection, which adds to patient comfort, decreased gonadotropin usage without compromising treatment success. Pregnancy rates for the two groups were not different, but the twice-daily group required significantly more FSH and hMG.

Another prospective, randomized, comparative study showed that a once-daily injection for a mixed stimulation protocol demonstrated superior clinical outcomes compared to a twice-a-day dosing schedule. The ongoing pregnancy rate was significantly higher (85%, p=0.007) with the once-daily protocol compared to the twice-a-day injection (38%). In addition, the cancellation rate was higher in the two-shot protocol (20%) vs. the single shot protocol (7%).

About ENDOMETRIN

ENDOMETRIN administered as a progesterone vaginal insert is indicated to support embryo implantation and early pregnancy by supplementation of corpus luteal function as part of an Assisted Reproductive Technology (ART) treatment for infertile women.

Only physicians thoroughly familiar with infertility treatment should prescribe ENDOMETRIN. In clinical trials (n=808), adverse reactions that occurred at a rate greater than or equal to two percent included: uterine spasm (3% to 4%) and vaginal bleeding (3%). Vaginal irritation, itching, burning or discomfort, urticaria, and peripheral edema were reported at an incidence of less than two percent. ENDOMETRIN is expected to have adverse reactions similar to other drugs containing progesterone (breast tenderness, bloating, mood swings, irritability, and drowsiness).

About MENOPUR

MENOPUR administered subcutaneously is indicated
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SOURCE Ferring Pharmaceuticals
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