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Research Identifies Predictors for Successful IVF
Date:11/10/2008

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Other studies showed similar results. In one, serum progesterone levels following use of ENDOMETRIN (n=98) and IM-PIO (n=275) were not statistically different. However, during the early weeks of pregnancy, mean progesterone levels (ng/ml) in patients who used ENDOMETRIN were significantly higher than levels achieved in women who used IM-PIO. At more than 26 days following oocyte retrieval, ng/ml for ENDOMETRIN was 110 and IM-PIO, 87 (p=.04).

Another study compared results in 145 women receiving ENDOMETRIN and 399 taking IM-PIO to determine the outcome of IVF with the long protocol. Clinical pregnancy rates were the same in both treatment groups.

In a study of 82 women with endometriosis who underwent IVF, those who used ENDOMETRIN for luteal support had significantly higher ongoing pregnancy rates (55%) than those who used IM-PIO (37%), and progesterone levels during the luteal phase were comparable.

MENOPUR vs. rFSH Only in PCOS Patients

In a retrospective cohort study, 64 women with polycystic ovarian syndrome (PCOS) undergoing IVF used MENOPUR with or without FSH in a long luteal phase agonist protocol. The control group (n=46) received FSH only. Patients receiving MENOPUR had shorter stimulations but used more gonadotropins (LH + FSH). Those in the FSH-only group had significantly more cycles cancelled for over-stimulation than the study population. There was no difference in embryos transferred or pregnancy rates between the two groups. The study demonstrated that stimulations with hMG are shorter (11.3 days vs. 12.6 days), use more total gonadotropins, and most importantly, have a lower cancellation rate (3.6% vs. 20%) due to over-response than stimulations using only FSH.

"Concerns that patients with PCOS should be stimulated with FSH alone because of their high endogenous LH levels may not be accurate. This study demonstrates that using MENOPUR improves controlled response in PCOS patients undergoing IVF compared
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SOURCE Ferring Pharmaceuticals
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