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Research Highlights New Approaches to Management of Blood Clotting and Bleeding Disorders
Date:12/8/2007

diopathic DVT. It has already been determined that the optimal duration of OAT for DVT can be tailored according to the presence of residual vein thrombosis (RVT), long-lasting blood clots that remain inside the vein, as RVT serves as a marker to assess the individual risk for recurrent thrombosis. However, in patients with idiopathic DVT who have not demonstrated RVT, the safety of early interruption of OAT is still debated. This prospective controlled study evaluated the safety of withholding OAT in patients with idiopathic DVT and without RVT, three months after the index thrombotic episode. The study evaluated two groups: DVT patients without RVT who stopped OAT after three months and those with RVT who continued OAT for an additional three months. During the period from 1999-2006, 518 patients were included in the study. In 206 patients (39.7 percent), RVT was considered absent (RVT negative group) and OAT was stopped; the remaining 312 patients continued receiving anticoagulants for an additional three months (RVT positive group). The study found that in patients without RVT, three months of OAT was safe even after an episode of idiopathic DVT. This indicates that individual markers for VT, such RVT, may help in the management of VT and can allow OAT duration to be tailored. The RVT finding applies to at least 30 percent of the entire DVT population and has an important clinical impact, indicating that patients at low risk of recurrent thrombosis can now safely withdraw from OAT after three months. This approach also carries a negligible risk for bleeding.

The study authors and press program moderator will be available for interviews after the press program or by telephone. In addition to blood clotting and bleeding disorders, additional press briefings will take place focusing on leukemias, sickle cell disease and thalassemia, hematologic malignancies, and transplantation. For the complete annual meeting schedule and additional information, please vi
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SOURCE American Society of Hematology
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