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Research Highlights New Approaches to Management of Blood Clotting and Bleeding Disorders
Date:12/8/2007

omen age 50-79. The investigators performed a nested case control study that measured baseline levels of coagulation markers in 215 women who developed VTE during follow-up and 867 age-matched controls. The joint effects of treatment assignment to either E regimen or placebo and prespecified abnormal levels of each coagulation factor on relative risk of VTE were estimated by logistic regression adjusting for age, race, body-mass index, and type of E regimen. The study reported new findings of elevated coagulation markers, F1-2 and PAP, as VTE risk factors in women in this prospective study nested in trials of E or E+P vs. placebo.

Lower levels of other coagulation markers protein C and free protein S and higher D-dimer F1-2 and PAP, all identified women at increased risk of VTE with hormones. If these findings are confirmed in further studies, measurement of these factors might assist women with decision- making on safety of E or E+P.

-- Extended Dacus study indicates that short-term anticoagulation is safe for patients with idiopathic deep vein thrombosis [Abstract #301]

Sergio Siragusa, MD, Istituto di Ematologia Policlinico Universitario di Palermo, Palermo, Italy

This study evaluated whether short-term oral anticoagulation therapy (OAT) is safe for patients with deep vein thrombosis (DVT) after an episode of idiopathic deep vein thrombosis (DVT of an obscure or unknown cause). OAT is a standard treatment for patients who have experienced venous thrombosis. It is used to reduce the risk of recurrent blood clotting and is typically administered using drugs such as warfarin and acenocoumarol. While anticoagulation therapy mitigates some risks for patients, it also increases the risk of major bleeding and therefore raises the question of how long patients can safely receive OAT. Currently, a period of three months is indicated for VT due to transient risk factors (i.e. surgery) while at least three to six months are required for i
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SOURCE American Society of Hematology
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