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Research Highlights New Approaches to Management of Blood Clotting and Bleeding Disorders
Date:12/8/2007

vessel. This type of clot may cause a number of fatal complications, including blocking a vessel in the lungs (pulmonary embolism) or brain (stroke). Rivaroxaban is an oral, direct Factor Xa inhibitor - the newest class of antithrombotic agents - in advanced clinical development for the prevention and treatment of thromboembolic disorders. Enoxaparin is a traditional blood thinner used to prevent deep vein thrombosis. The study included a total of 4,541 randomized patients who either received rivaroxaban 10 mg beginning six to eight hours after surgery and once daily thereafter, or enoxaparin 40 mg once daily beginning the evening before surgery and restarting six to eight hours following surgery. Results showed that rivaroxaban was significantly more effective than enoxaparin for extended prophylaxis after THA. This is the first pivotal trial to demonstrate the efficacy and safety of a fixed, unmonitored dose of an oral, direct Factor Xa inhibitor for extended thromboprophylaxis patients after THA.

-- Women's Health Initiative evaluates coagulation factors, postmenopausal hormone replacement therapy, and the risk of venous thrombosis [Abstract #127]

Mary Cushman, MD, MSc, University of Vermont, Burlington, VT

This session will present preliminary data from two trials of the Women's Health Initiative on two different estrogen regimens to evaluate coagulation markers as susceptibility factors for postmenopausal hormone-related venous thrombosis (VTE). Postmenopausal estrogen (E) therapy, especially in combination with progestin (P), doubles the relative risk of venous thrombosis (VTE). Risk with hormones is higher with increasing age, obesity, and the presence of factor V Leiden, the most common hereditary blood coagulation disorder in the United States. These two placebo-controlled double-blind randomized trials evaluated two E regimens - E (conjugated equine estrogens) or E+P (E + medroxyprogesterone acetate), in 16,608 postmenopausal w
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SOURCE American Society of Hematology
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