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Research Highlights New Approaches to Management of Blood Clotting and Bleeding Disorders
Date:12/8/2007

es undertaken in patients with chronic ITP, as platelets targeted for destruction will often meet their fate in the spleen. Splenectomy is said to be successful in 60 percent of cases although it is less successful in older people. AMG 531 is a novel "peptibody" that acts by stimulating platelet production at the thrombopoietin receptor. Thrombopoietin is a hormone that promotes platelet production by the bone marrow. In this study, subcutaneous AMG 531 or placebo was administered weekly for 24 weeks at a starting dose of 1µg/kg, and adjusted to maintain a target platelet count of 50-200x109/L in the 63 enrolled splenectomized patients with ITP. The results indicated that AMG 531 was well tolerated and effectively increased and sustained platelet counts in patients. AMG 531-treated patients required less frequent rescue medications (medications needed in an emergency to re-stabilize platelet counts and prevent or treat bleeding) in comparison with those receiving the placebo, and were able to reduce their use of concurrent ITP therapies.

-- RECORD1 is the first pivotal trial to demonstrate the efficacy and safety of a fixed, unmonitored dose of an oral, direct Factor Xa inhibitor -- rivaroxaban -- for extended prevention of blood clotting after a total hip replacement [Abstract #6]

Bengt I. Eriksson, MD, PhD, Ortopedkliniken, Sahlgrenska University Hospital/Ostra, Goteborg, Sweden

This multinational, randomized, double-blind, double-dummy phase III trial studied the efficacy and safety of oral rivaroxaban in comparison to subcutaneous enoxaparin to prevent blood clotting (a process known as thromboprophylaxis) for five weeks in patients undergoing a total hip replacement (THA). Thromboprophylaxis is recommended for at least 10 days and for up to four to five weeks after total hip replacement in order to avoid the formation of a thrombembolism, or a clot in a blood vessel that breaks loose and is carried by the blood stream to plug another
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SOURCE American Society of Hematology
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