Navigation Links
Research Highlights Genetic Risk for Autism
Date:4/28/2009

ory medicine at the University of Pennsylvania; and Kai Wong, also at Children's Hospital.

Hakonarson, Schellenberg and Wong presented the findings Tuesday during a London-based teleconference. They are published online today in Nature.

"This is the first crack in the facade of this disease," according to Schellenberg. He said the findings represent "the next step in understanding the fundamental molecular biology of what's happening in autism."

"And this really gets us a major jump, we think, in terms of knowing what targets to look at," he said, referring to the development of therapies to combat both the risk for and onset of autism.

For the first study, the researchers conducted a genetic analysis of more than 10,000 children, of whom 4,500 had a diagnosis of autism spectrum disorder, a grouping of neural developmental problems involving verbal skills as well as social interaction and behavior.

The effort yielded two autism-associated culprits -- variants of the CDH10 and CDH9 genes -- which the researchers suggested could underlie the risk for autism in about 15 percent of cases.

For the second study, researchers looked specifically at the genetic "roadmap" of children with autism spectrum disorder and isolated two genes along the so-called "ubiquitin pathway" -- the UBE3A and PARK2 genes-- that appeared vulnerable to deletion/replication variations. The variations seemed to undermine the genes' ability to ensure smooth cell communication across brain synapses. That study involved 859 children with an autism spectrum disorder and more than 1,400 children without such disorders.

Collectively, these findings emphasize the complexity of the genetic underpinnings of autism, the researchers said. And they stressed that having these genetic predispositions does not necessarily mean a higher risk for the disorder in the absence of other critical factors.

"We think that, in most cas
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research Highlights Genetic Risk for Autism
(Date:3/29/2015)... 2015 Elfster.com, the top-rated Secret Santa ... promotional plans to publicize its gift exchange generator technology ... Known as the leader in Secret Santa online gift ... adjacent markets can see the opportunities as well. , ... explained Peter Imburg, CEO of Elster.com. "With Christmas and ...
(Date:3/29/2015)... 2015 Adults who are comparing the ... on the web can now use the QuotesPros.com website ... can now be explored while researching the automated database ... the differences between what a term policy provides and ... for some men and women. Insurers typically provide base ...
(Date:3/29/2015)... IL (PRWEB) March 29, 2015 The ... Foundation for Women’s Cancer announce today that Dr. ... recipient of the Claudia Cohen Research Foundation Prize for ... at the Society of Gynecologic Oncology 46th Annual Meeting ... Director of the Cedars-Sinai Women’s Cancer Program at the ...
(Date:3/29/2015)... At this initial launch, the ... health information around medical conditions that individuals face, ... as well as helping them find solutions to ... conditions using evidenced based information in print and ... around them., ,     Diabetes, , ...
(Date:3/29/2015)... North American Seminars receives Texas Board ... Education Courses . , Utilizing Pilates to ... TPTA, approval # 56399TX      , The Interactive ... complex - 10.5 hours - Texas Board of Physical ... Treatment of the SI Joint - 10 hours - ...
Breaking Medicine News(10 mins):Health News:Gift Exchange Generator Promotion Achieves Early Success, Announces Elfster 2Health News:Permanent Life Insurance Quotes Now Offered Through Web Search System at Insurer Website Online 2Health News:Dr. Beth Y. Karlan Named Recipient of the Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher 2015 2Health News:Dr. Beth Y. Karlan Named Recipient of the Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher 2015 3Health News:Dr. Beth Y. Karlan Named Recipient of the Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher 2015 4Health News:Krame Health Solutions Announces Release of AfroHealthLink, an Interactive Health Resource Center Tailored to Individuals of African & Caribbean Descent Around the World 2Health News:Krame Health Solutions Announces Release of AfroHealthLink, an Interactive Health Resource Center Tailored to Individuals of African & Caribbean Descent Around the World 3
... Mental Illness Coverage commends the United States Senate for,passing ... setting the stage for,enactment of a strong parity bill. ... V. Domenici (R-NM), Edward M. Kennedy (D-MA),and Michael B. ... use,disorder insurance coverage on par with physical health care ...
... Fla. -- As many as one in four people ... upper abdomen, and physicians have almost nothing to offer ... a small but novel study, researchers have found evidence ... upper intestine of affected individuals, which suggests a fresh ...
... (Sept. 19, 2007) -- Each year in the U.S. ... their donation literally go down the drain. Of the ... majority (about two-thirds) of the four million whole blood-derived ... this valuable resource with much more expensive single donor ...
... Segal Health Plan Cost,Trend Survey forecasts continued declines in ... medical trends. And, although a growing,number of health plans ... still significantly above general inflation. Key findings,include: ... for point-of-service (POS) medical ...
... of the,House and founder of the Center for Health ... lawmakers on Capitol Hill,today that while he understood how ... Children,s Health Insurance Program (SCHIP) is to,shaping the future ... lose sight of the hundreds of thousands of poor ...
... 19 Hologic, Inc.,(Nasdaq: HOLX ) today announced ... the UBS Global Life Sciences Conference being held,September 24 ... New York, NY. Interested parties are invited to ... on Wednesday, September 26, 2007 at 4:30,p.m. Eastern Time ...
Cached Medicine News:Health News:Common abdominal pain may be due to a potentially treatable newly recognized inflammatory reaction 2Health News:Critical blood shortages eased by new technology 2Health News:Critical blood shortages eased by new technology 3Health News:Segal Survey Predicts Declines in Trends for Fifth Consecutive Year 2Health News:Center for Health Transformation Founder Newt Gingrich Calls on Congress to Pass a 'Clean' SCHIP Six-Month Extension 2
(Date:3/30/2015)... ISELIN, N.J. , March 30, 2015 /PRNewswire/ ... a medical device company focused on non-invasive continuous ... it has achieved its wireless mobile communication milestone, ... sensor to transmit data to any mobile platform. ... the strategic transformation of the Company,s technology from ...
(Date:3/30/2015)... -- RnRMarketResearch.com adds "CountryFocus: Healthcare, Regulatory and ... research report of 295 pages with latest updates, data ... The report " CountryFocus: Healthcare, Regulatory and Reimbursement ... and analysis of the healthcare, regulatory and reimbursement landscape ... key trends in the country,s healthcare market, and provides ...
(Date:3/30/2015)... 2015  IRIDEX Corporation (Nasdaq: IRIX ) today ... granted the Company a patent for a new proprietary ... eye surgery. The iClip Closure Device will initially be ... a broader range of ophthalmic surgical procedures in the ... procedure used in the treatment of glaucoma to drain ...
Breaking Medicine Technology:Echo Therapeutics, Inc. Achieves Wireless Mobile Communication Milestone 2Echo Therapeutics, Inc. Achieves Wireless Mobile Communication Milestone 3Spain Medical Devices Market Worth $12 Billion With 4.5% CAGR to 2020, Says RnRMarketResearch.com 2Spain Medical Devices Market Worth $12 Billion With 4.5% CAGR to 2020, Says RnRMarketResearch.com 3Spain Medical Devices Market Worth $12 Billion With 4.5% CAGR to 2020, Says RnRMarketResearch.com 4Spain Medical Devices Market Worth $12 Billion With 4.5% CAGR to 2020, Says RnRMarketResearch.com 5IRIDEX Granted U.S. Patent for Disposable Device for Efficient and Predictable Wound Closure in Eye Surgeries 2
... 19, 2011 Enhanced Equity Fund (EEF), a healthcare-focused ... investment in MedTest DX, Inc. (MedTest), a medical diagnostic ... to purchase the chemistry diagnostics business from Polymedco, Inc. ... of EEF.  Terms were not disclosed. "EEF ...
... 2011 Wound Management Technologies, Inc., (OTCQB: WNDM | ... the publication of an interview of its President Deborah ... of interviews with CEOs and CFOs of publicly traded ... conducted by Lynn Fosse, Senior Editor, CEOCFOInterviews.com include why ...
Cached Medicine Technology:Enhanced Equity Fund and James White Invest in MedTest DX, Inc. 2WNDM President Interviewed; Discusses 2011 Outlook and Beyond 2WNDM President Interviewed; Discusses 2011 Outlook and Beyond 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: