Navigation Links
Research Highlights Genetic Risk for Autism
Date:4/28/2009

ory medicine at the University of Pennsylvania; and Kai Wong, also at Children's Hospital.

Hakonarson, Schellenberg and Wong presented the findings Tuesday during a London-based teleconference. They are published online today in Nature.

"This is the first crack in the facade of this disease," according to Schellenberg. He said the findings represent "the next step in understanding the fundamental molecular biology of what's happening in autism."

"And this really gets us a major jump, we think, in terms of knowing what targets to look at," he said, referring to the development of therapies to combat both the risk for and onset of autism.

For the first study, the researchers conducted a genetic analysis of more than 10,000 children, of whom 4,500 had a diagnosis of autism spectrum disorder, a grouping of neural developmental problems involving verbal skills as well as social interaction and behavior.

The effort yielded two autism-associated culprits -- variants of the CDH10 and CDH9 genes -- which the researchers suggested could underlie the risk for autism in about 15 percent of cases.

For the second study, researchers looked specifically at the genetic "roadmap" of children with autism spectrum disorder and isolated two genes along the so-called "ubiquitin pathway" -- the UBE3A and PARK2 genes-- that appeared vulnerable to deletion/replication variations. The variations seemed to undermine the genes' ability to ensure smooth cell communication across brain synapses. That study involved 859 children with an autism spectrum disorder and more than 1,400 children without such disorders.

Collectively, these findings emphasize the complexity of the genetic underpinnings of autism, the researchers said. And they stressed that having these genetic predispositions does not necessarily mean a higher risk for the disorder in the absence of other critical factors.

"We think that, in most cas
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research Highlights Genetic Risk for Autism
(Date:9/21/2014)... (PRWEB) September 21, 2014 High in ... teams of disabled and able-bodied athletes rafted the Colorado ... a ropes course in pursuit of outdoor adventure. At ... national non-profit World T.E.A.M. Sports, disabilities proved to be ... successfully completed the three stage event. , Each participating ...
(Date:9/21/2014)... experienced review website in the global market, Top10BestSEOHosting.com, has ... that FatCow ( http://www.top10bestseohosting.com/go/FatCow.com/ ), GoDaddy and Bluehost are ... been a boom in websites in recent years, and ... the number of web hosting companies that offer a ... (Virtual Private Server) is the method of partitioning a ...
(Date:9/21/2014)... BambooIndustry.com, an experienced producer of natural bamboo items, has ... http://www.bambooindustry.com/products/bamboo-panel/ ). The company’s excellent panels are very popular ... discounted prices now, from 10 to 30 percent off. ... are available in many specifications; they are promised to ... finely manufactured by qualified workers. They are specially offered ...
(Date:9/21/2014)... Faculty and staff at Garrison Forest School ... Owings Mills, Md., kicked off the academic year by taking ... is the first independent school to receive the bands— which ... sleep patterns— as part of a pilot program with ... specialty chain. The Vivofit bands are just one tool in ...
(Date:9/21/2014)... According to latest National Vital Statistics Reports ... (10.5 births per 1,000 women in 2013). Since 2000, the ... by 2 percent per year. The birth rate for women ... over) also rose, the first such increase since 2008. Ultimately ... as many first births to women aged 35 and older ...
Breaking Medicine News(10 mins):Health News:Disabled Athletes Excel at World T.E.A.M. Sports’ Adventure Team Challenge 2Health News:Disabled Athletes Excel at World T.E.A.M. Sports’ Adventure Team Challenge 3Health News:Top10BestSEOHosting.com: FatCow, GoDaddy And Bluehost Are The Best VPS Hosting Suppliers 2Health News:Discounted Bamboo Panels For Sale At BambooIndustry.com 2Health News:Garrison Forest School Leader in Independent School Wellness Programs 2Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 2Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 3Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 4
... is too expensive to eat a well-balanced diet may be surprised ... have changed eating healthily may actually be cheaper than their current ... New York, suggested that a healthy diet does not have to ... time, the cost of a healthy diet may be less than ...
... of removing cancerous kidneys through a small incision with ... and instuments. This is the hand-assisted Laproscopic technique, which ... standard laproscopic procedure. ,The research, being presented at the ... from the University of Michigan(U-M) Health System,// U.S., may ...
... which can be hard on the body. Stress affects the ... take to reduce impact of stress, and it's probably good ... sales rep, found that appointments and deadlines can be stressful. ... seem small, but they do tend to affect your blood ...
... Epidemiology, Biomarkers and Prevention, eating a daily multivitamin with ... the genetic risk of developing colon cancer. ,According ... colon cancer -- a parent or sibling are at ... Fuchs, lead investigator and assistant professor of medicine at ...
... by a biomedical engineer at the University of Pittsburgh ... of your eyes. The prototype device merges the visual ... ultrasound scan of what lies beneath. It creates the ... actual 3D location with the patient, showing blood vessels, ...
... nanobots it not with us yet, a tiny, inexpensive motor ... in the near future, according to Penn State engineer.,The smallest ... State’s Materials Research Institute is about the size of a ... 4 mm long.// ,Tiny, but powerfull, the smallest motor’s ...
Cached Medicine News:Health News:Eating healthy is cost effective 2Health News:Lessening operation and recovery time 2Health News:Folic Acid blows Gene-based Colon Cancer 2Health News:New form of ultrasonic vision 2Health News:Mini motor for micromedical applications 2
(Date:9/19/2014)... 2014 The Parenteral Drug Association (PDA) is ... changes protocols. The new initiative stems ... by industry participants and regulatory authority representatives at the ... Washington, DC . Representatives of both ... the workshop. Attendees indicated openness to engaging regulators and ...
(Date:9/19/2014)... , Sept. 19, 2014 /PRNewswire-iReach/ ... Outlook to 2020″, provides key market ... Surgery devices market. The report provides ... and volume (in units) within market ... Colonoscopes, Sigmoidoscopes, Esophagoscopes & Gastroscopes, Duodenoscopes, ...
(Date:9/19/2014)... 19, 2014  The board of directors of AbbVie ... cash dividend of $0.42 per share.  ... stockholders of record at the close of business on ... a global, research-based biopharmaceutical company formed in 2013 following ... its expertise, dedicated people and unique approach to innovation ...
Breaking Medicine Technology:PDA Launches Effort to Harmonize Global Post-Approval Changes Protocols 2United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 2United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 3United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 4United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 5
... David B. Snow Jr. , chairman and chief executive officer, Medco Health Solutions, ... Health Care Conference in New York on Wednesday, May 26, 2010 . , ... The presentation at the Hilton, New York , will begin at ... to attend. , , , ...
... 20 As the medical device industry gathers at Sales ... Management software, offers medical device companies a solution to promote and sell ... , , ... will lead the workshop "Sales-Friendly Compliant Content Communication: How to Score Wins ...
Cached Medicine Technology:Medco to Present at the 2010 Citi Investment Research Global Health Care Conference 2Prolifiq Offers Best Practices Solution for Selling Medical Devices in Tough Regulatory Environment 2Prolifiq Offers Best Practices Solution for Selling Medical Devices in Tough Regulatory Environment 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: