Navigation Links
Research Finds 'New Crop' of Breast Cancer Genes
Date:6/1/2009

Study in mice also suggests possible treatment with blood pressure med

MONDAY, June 1 (HealthDay News) -- Researchers say they have found a gene common in up to one in five breast cancers that a blood pressure medication might combat.

Their study, published online in this week's issue of the Proceedings of the National Academy of Science, found that the AGTR1 gene makes healthy breast cells act like cancer cells. But tests on mice with tumors containing the gene found that the blood pressure drug losartan (Cozaar) stopped that behavior and shrank the tumors by 30 percent within eight weeks of treatment, according to the researchers, from the University of Michigan Comprehensive Cancer Center.

The blood pressure drug had no effect on tumors lacking the gene.

"We suspect our analysis has uncovered a new crop of potentially important breast cancer genes," study author Dr. Arul Chinnaiyan, a pathology professor at the university's medical school, said in a news release from the school. "What's also exciting is this gene is blocked by a drug that's already available on the market."

In a study of breast tumors, the researchers found that AGTR1 was the second most commonly expressed gene, after ERBB2, which is more commonly known as HER2 and is found in up to 30 percent of all human breast cancers. In fact, AGTR1, which was found in 10 percent to 20 percent of the breast tumors, was found in excess only in tumors that lacked ERBB2 and that expressed the estrogen receptor, known as ER-positive.

"AGTR1 is very analogous to HER2 or ERBB2," said Chinnaiyan, who is also director of the Michigan Center for Translational Pathology. "HER2 is a bona fide treatment target for patients with that type of breast cancer. This research defines a novel subtype of ER-positive breast cancer that we hope can be similarly targeted for treatment."

She also said the findings should lead to a more detailed study of losartan as a treatment for AGTR1-positive breast tumors.

More information

The American Cancer Society has more about breast cancer.



-- Kevin McKeever



SOURCE: University of Michigan, news release, June 1, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Market Research Study Shows Lung Cancer Treatments Differ Significantly by Both Age and Geography
2. Michael J. Fox Foundation Announces Launch of PD Online Research
3. New research identifies more effective tools for detection of colorectal cancer
4. Researchers determine predicting factors of positive lung cancer diagnoses in chest radiographs
5. LA BioMed researcher receives clinical teaching award
6. BD Biosciences Launches New Cell Analyzer for Complex Multicolor Experiments in Disease and Drug Development Research
7. Researchers Spot Genes Linked to Testicular Cancer
8. Millennium Research Groups New Perception Pulse Product Offers Clients an Innovative New Customer Behavior and Loyalty Tracking Tool
9. Mrs. Lily Safra, President of the Edmond J. Safra Foundation, to Announce Major New Medical Research Initiative During Israel Visit
10. UCLA cancer researchers first to link intestinal inflammation with systemic chromosome damage
11. Aderans Research BIO International Press Release
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research Finds 'New Crop' of Breast Cancer Genes
(Date:2/10/2016)... NASHVILLE, Tenn. (PRWEB) , ... February 10, 2016 ... ... by the American Academy of Emergency Medicine , an emergency medicine ... of practice management services . , The American Academy of Emergency Medicine, ...
(Date:2/10/2016)... ... February 10, 2016 , ... The Wickman Agency in ... assist the local community. Pledging to select a new beneficiary every 60 days, ... area. Their goal is to bring community awareness to important local causes by ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... 10 ... Brand. There were three leading bottled water brand owners that topped the list as ... enhance connectivity and optimize conversion. The premier brand was Tibet 5100, a top notch ...
(Date:2/10/2016)... ... , ... Dr. Jessica Barron, of Barron Family Dental in Thornton, Colorado ... families in the North Metro Denver area. The new dental practice focuses on comfort ... all in the most relaxing environment. , While some dental visits can create anxiety ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... bring together more than 200 of the country’s top healthcare executives to share ... “The true benefit of the Forum is the provider-centric perspective, experience, expertise and ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... -- Resolve Therapeutics, LLC, a clinical stage biopharmaceutical company ... of lupus and Sjogrens syndrome, today announced the ... in patients with systemic lupus erythematosus (SLE) with ... --> Data from a multicenter ... RSLV-132 in 32 subjects with SLE demonstrate the ...
(Date:2/10/2016)... HILLS, Calif. , Feb. 10, 2016  Rich ... "Company") today announced a 1-for-100 reverse split of its ... the opening of trading on Thursday, February 11, 2016. ... basis under new CUSIP number 76303T308 and temporary ticker ... will commence trading under the ticker symbol (RCHA).  ...
(Date:2/10/2016)... MEMPHIS, Tenn. , Feb. 10, 2016 ... School of Nursing received an in-kind ... of a VeinViewer® Vision vein finder ... donation will help students as they learn ... blood, combining technology with traditional technique. ...
Breaking Medicine Technology: