Navigation Links
Research Finds 'New Crop' of Breast Cancer Genes
Date:6/1/2009

Study in mice also suggests possible treatment with blood pressure med

MONDAY, June 1 (HealthDay News) -- Researchers say they have found a gene common in up to one in five breast cancers that a blood pressure medication might combat.

Their study, published online in this week's issue of the Proceedings of the National Academy of Science, found that the AGTR1 gene makes healthy breast cells act like cancer cells. But tests on mice with tumors containing the gene found that the blood pressure drug losartan (Cozaar) stopped that behavior and shrank the tumors by 30 percent within eight weeks of treatment, according to the researchers, from the University of Michigan Comprehensive Cancer Center.

The blood pressure drug had no effect on tumors lacking the gene.

"We suspect our analysis has uncovered a new crop of potentially important breast cancer genes," study author Dr. Arul Chinnaiyan, a pathology professor at the university's medical school, said in a news release from the school. "What's also exciting is this gene is blocked by a drug that's already available on the market."

In a study of breast tumors, the researchers found that AGTR1 was the second most commonly expressed gene, after ERBB2, which is more commonly known as HER2 and is found in up to 30 percent of all human breast cancers. In fact, AGTR1, which was found in 10 percent to 20 percent of the breast tumors, was found in excess only in tumors that lacked ERBB2 and that expressed the estrogen receptor, known as ER-positive.

"AGTR1 is very analogous to HER2 or ERBB2," said Chinnaiyan, who is also director of the Michigan Center for Translational Pathology. "HER2 is a bona fide treatment target for patients with that type of breast cancer. This research defines a novel subtype of ER-positive breast cancer that we hope can be similarly targeted for treatment."

She also said the findings should lead to a more detailed study of losartan as a treatment for AGTR1-positive breast tumors.

More information

The American Cancer Society has more about breast cancer.



-- Kevin McKeever



SOURCE: University of Michigan, news release, June 1, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Market Research Study Shows Lung Cancer Treatments Differ Significantly by Both Age and Geography
2. Michael J. Fox Foundation Announces Launch of PD Online Research
3. New research identifies more effective tools for detection of colorectal cancer
4. Researchers determine predicting factors of positive lung cancer diagnoses in chest radiographs
5. LA BioMed researcher receives clinical teaching award
6. BD Biosciences Launches New Cell Analyzer for Complex Multicolor Experiments in Disease and Drug Development Research
7. Researchers Spot Genes Linked to Testicular Cancer
8. Millennium Research Groups New Perception Pulse Product Offers Clients an Innovative New Customer Behavior and Loyalty Tracking Tool
9. Mrs. Lily Safra, President of the Edmond J. Safra Foundation, to Announce Major New Medical Research Initiative During Israel Visit
10. UCLA cancer researchers first to link intestinal inflammation with systemic chromosome damage
11. Aderans Research BIO International Press Release
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research Finds 'New Crop' of Breast Cancer Genes
(Date:4/29/2016)... , ... April 29, 2016 , ... In an ... and divorcee, shares her enthusiasm for Botox and lip injections, which she underwent in ... youth oriented Coachella Valley Music and Arts Festival. The article explains that Ms. Mirmelli’s ...
(Date:4/29/2016)... ... April 29, 2016 , ... Shamangelic Healing, ... addition Onnit brand Alpha BRAIN and New Mood Daily-Stress Formula for brain optimization ... optimization products to the store is just one more way Shamangelic Healing supports ...
(Date:4/29/2016)... ... April 29, 2016 , ... The American workforce is ... even security. Most importantly, employees are the single most important asset in creating ... so unhappy? , Just under half of American workers are emotionally checked out ...
(Date:4/29/2016)... ... 2016 , ... Conditions were ideal for Global Lyme Alliance’s (GLA) 2nd annual ... skies, a light breeze and temperatures in the 60s. Over 400 runners, walkers and ... Walk and 1-mile walk were held to increase awareness about Lyme disease and ...
(Date:4/29/2016)... ... 2016 , ... Spine Team Texas, a comprehensive spine physician group specializing in ... physicians has been invited to be a featured speaker at the Texas Society of ... April 30, 2016. , Dr. R. Scott McPherson, a physical medicine and rehabilitation ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)...  Hologic, Inc. (Nasdaq: HOLX ) ... fiscal second quarter ended March 26, 2016.  GAAP ... 41.2%, and non-GAAP diluted EPS of $0.47 increased ... a reported basis, and 6.3% on a constant ... good quarter, highlighted by 14.6% growth in non-GAAP ...
(Date:4/27/2016)... ALBANY, New York , April 27, 2016 /PRNewswire/ ... new market report titled, "Skincare Devices Market - Global ... - 2023." According to the report, the global skincare ... 2014 and is anticipated to expand at a CAGR ... 17,299.4 Mn in 2023. Browse the full Skincare ...
(Date:4/27/2016)... 2016 Research and ... Anesthesia Disposables Market 2016-2020"  report to their ... ,The global anesthesia disposables market is set ... during the period 2016-2020.  Healthcare-acquired ... patients, safety. Organizations like the CDC and ...
Breaking Medicine Technology: