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Research Findings on Nine GlaxoSmithKline Cancer Compounds to be Presented at ASCO 2009
Date:5/11/2009

approved lapatinib in combination with capecitabine for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2/ErbB2 and who have received prior therapy including an anthracycline, a taxane and trastuzumab. On June 10, 2008, the European Commission granted a conditional marketing authorization for lapatinib in all 27 European Union (E.U.) member states. Other countries in which lapatinib is authorized for marketing include Japan, Australia, India, Brazil, Russia, Switzerland, Turkey, South Korea, Taiwan and others around the world. Registration dossiers for lapatinib have been filed in Canada, China, Mexico and a number of countries in Latin America, Middle East, Africa and Asia Pacific.

For more information see full prescribing information.

About AVODART(R) (dutasteride)

Dutasteride inhibits both type 1 and type 2 5-alpha reductase isoenzymes, which are responsible for converting testosterone to dihydrotestosterone (DHT), the most potent male hormone in the prostate. Basic science studies indicate that both types of the enzyme - type 1 and type 2 - are present in prostate tissue and that the type 1 form is increased in prostate cancer, including high grade cancer. The clinical significance of the in vitro dual inhibition of type 1 and type 2 5-alpha reductase isoenzymes has not been established.

Dutasteride is indicated for the treatment of moderate-to-severe symptoms of benign prostatic hyperplasia (BPH) in men with an enlarged prostate. It has been shown to improve urinary symptoms, reduce the risk of acute urinary retention (AUR), and the risk of BPH-related surgery.

Women and children should not take dutasteride. Women who are or could become pregnant should not handle dutasteride due to the potential risk of a specific birth defect. Blood should not be donated until at least six months following the last
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