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Research Findings on Nine GlaxoSmithKline Cancer Compounds to be Presented at ASCO 2009
Date:5/11/2009

an Kettering Cancer Center; Presentation on May 30.

Breast Cancer: Investigational data on new biomarkers in TYKERB(R)/TYVERB(R) (lapatinib) based treatment.

  • "cMET expression in Her2+ MBC patients with first-line lapatinib (L) treatment." Dr. Y. Liu, GlaxoSmithKline, Collegeville, PA; Poster presentation on June 1.
  • "Clinical benefit of lapatinib-based therapy in patients with HER2-positive breast tumors expressing p95HER2." Dr. L. Prudkin, Vall d'Hebron University Hospital, Barcelona, Spain; Poster presentation on June 1.

Leukemia: Data from the Phase III trial for the investigational compound, ofatumumab, in advanced stage blood cancer.

  • "Ofatumumab, a novel CD20 mAB, is active regardless of prior rituximab exposure in patients with fludarabine-and alemtuzumab-refractory or bulky fludarabine-refractory chronic lymphocytic leukemia (CLL)." Dr. W. Wierda, MD Anderson, the University of Texas MD Anderson Cancer Center; Poster presentation on May 30.

Other Investigational GSK Data

Data on the following compounds will also be presented at ASCO 2009: AVODART(R) (dutasteride), elesclomol, eltrombopag, topotecan and GSK923925.

About TYKERB(R)/TYVERB(R) (lapatinib)

Lapatinib is an oral small-molecule inhibitor of the HER2/ErbB2 tyrosine kinase receptor. Stimulation of HER2/ErbB2 is associated with cell proliferation and with multiple processes involved in tumor progression and metastases. Overexpression of these receptors has been reported in a variety of human tumors and is associated with poor prognosis and reduced overall survival.

Lapatinib, in combination with capecitabine, is authorized in 74 countries. On March 13, 2007, the U.S. FDA
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SOURCE GlaxoSmithKline
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