Navigation Links
Research Explains Benefit of 'Mini Heart Attack'
Date:12/12/2008

Stressing cardiac cells may make them more resilient during real attack, experts say

FRIDAY, Dec. 12 (HealthDay News) -- Doctors have long known that the creation of a "mini heart attack" -- by cutting off and then restoring blood flow to arteries -- can actually reduce the damage from a subsequent major heart attack.

Now they may know how that protective effect occurs, according to research from the University of Rochester Medical Center (URMC), in New York.

The method, called "ischemic preconditioning" (IPC), somehow shields heart tissue against damage caused by subsequent, prolonged blood vessel blockages.

In their study on rat hearts, the URMC team found that IPC caused more of an important molecule called nitro-linoleic acid (LNO2) to be produced inside cells damaged by a sudden drop in blood supply (ischemia).

"LNO2 appears to be important in the mechanism by which IPC triggers the body's natural defense mechanisms against heart attack before the major attack comes," Paul S. Brookes, an associate professor of anesthesiology and of pharmacology and physiology, said in an URMC news release.

"Obviously, this natural response, when it follows a major heart attack, is often too little too late. Our hope is that boosting the effect in patients at high risk, perhaps by administering LNO2 beforehand, will reduce heart attack damage in the future. Even sooner, we may be able to dramatically reduce reperfusion injury suffered in surgical settings," Brookes said.

The findings, published in the current issue of Cardiovascular Research, could lead to the development of new drugs to treat people at high risk for heart attack or stroke. It may also help in efforts to find ways to prevent damage caused when heart surgeons temporarily cut off blood flow to perform coronary artery bypass graft surgeries.

More information

The American Heart Association has more about heart attack.



-- Robert Preidt



SOURCE: University of Rochester Medical Center, news release, Dec. 2, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Millennium Research Group Analyst Available to Comment on FDAs Premarket Approval Recommendation of Genzyme Biosurgerys Synvisc Single-Injection Product for the Knee
2. Dignitas Personae, Vatican Instruction on Bioethics, Welcomed for Guidance on Issues of Procreation, Medical Research
3. Betty Whites Video States Support for Funding Humane Research to Help Pets and Wild Animals - Actress is 40-Year Champion of Morris Animal Foundation
4. The American Federation for Medical Research Says Daschle Must Cure Clinical Research Crisis if Change Is To Take Hold in U.S. Health Care System
5. Mayo Clinic researchers find tamoxifens power comes from endoxifen
6. LATH wins contract to boost health research capacity in Malawi
7. University of Minnesota receives $40 million for type 1 diabetes research
8. Dr. Ben Berkhout awarded Retrovirology Prize for contribution to HIV research
9. Researcher Receives Free Flow Cytometer System as First Winner of Accuri(R) Flow Cytometer Creativity Awards Program
10. New Poll Warns Daschle, Obama: Mandatory Health Insurance Big Loser With Public; Voters Want Return on Stem Cell Research
11. Seven life scientists get research boost to set up in Europe
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research Explains Benefit of 'Mini Heart Attack'
(Date:10/12/2017)... ... 2017 , ... Leading pediatric oncology experts at Children’s National Health System ... Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of ...
(Date:10/12/2017)... RAPIDS, Mich. (PRWEB) , ... October 12, 2017 ... ... Wellness, has been named one of Michigan’s 2017 Best and Brightest in Wellness® ... and Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. ...
(Date:10/12/2017)... BALTIMORE (PRWEB) , ... October 12, 2017 , ... ... average of $3,296 in property taxes a year. In some states—like New York, ... higher. , By contrast, many overseas retirement havens have extremely low property-tax rates, ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... University of California Berkeley, and other leading institutions in announcing the launch of ... institutions to change the way animals are raised for food. , Founding members ...
(Date:10/12/2017)... ... October 12, 2017 , ... Nvision Biomedical Technologies ... with the addition of industry sales leader, Thomas (Tom) Slott, as Senior Vice ... distribution and sales network, direct the efforts of the surgical sales teams, manage ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... Sept. 22, 2017 Janssen Biotech, Inc. (Janssen) ... letter from the U.S. Food and Drug Administration (FDA) ... sirukumab for the treatment of moderately to severely active ... clinical data are needed to further evaluate the safety ... active RA. ...
(Date:9/19/2017)... --  ZirMed Inc ., a recognized leader in cloud-based revenue ... been ranked #1 by its users for the seventh consecutive ... Survey. ZirMed was recognized as the top-ranked end-to-end revenue cycle ... over 200 beds and holds one of the longest #1 ... ...
(Date:9/12/2017)... 12, 2017   EcoVadis , the leading platform for environmental, social ... annual edition of its Global CSR Risk and Performance Index. The report ... based on Scorecard Ratings that analyzed nearly 800,000 data points across the ... ... ...
Breaking Medicine Technology: