Navigation Links
Research Explains Benefit of 'Mini Heart Attack'
Date:12/12/2008

Stressing cardiac cells may make them more resilient during real attack, experts say

FRIDAY, Dec. 12 (HealthDay News) -- Doctors have long known that the creation of a "mini heart attack" -- by cutting off and then restoring blood flow to arteries -- can actually reduce the damage from a subsequent major heart attack.

Now they may know how that protective effect occurs, according to research from the University of Rochester Medical Center (URMC), in New York.

The method, called "ischemic preconditioning" (IPC), somehow shields heart tissue against damage caused by subsequent, prolonged blood vessel blockages.

In their study on rat hearts, the URMC team found that IPC caused more of an important molecule called nitro-linoleic acid (LNO2) to be produced inside cells damaged by a sudden drop in blood supply (ischemia).

"LNO2 appears to be important in the mechanism by which IPC triggers the body's natural defense mechanisms against heart attack before the major attack comes," Paul S. Brookes, an associate professor of anesthesiology and of pharmacology and physiology, said in an URMC news release.

"Obviously, this natural response, when it follows a major heart attack, is often too little too late. Our hope is that boosting the effect in patients at high risk, perhaps by administering LNO2 beforehand, will reduce heart attack damage in the future. Even sooner, we may be able to dramatically reduce reperfusion injury suffered in surgical settings," Brookes said.

The findings, published in the current issue of Cardiovascular Research, could lead to the development of new drugs to treat people at high risk for heart attack or stroke. It may also help in efforts to find ways to prevent damage caused when heart surgeons temporarily cut off blood flow to perform coronary artery bypass graft surgeries.

More information

The American Heart Association has more about heart attack.



-- Robert Preidt



SOURCE: University of Rochester Medical Center, news release, Dec. 2, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Millennium Research Group Analyst Available to Comment on FDAs Premarket Approval Recommendation of Genzyme Biosurgerys Synvisc Single-Injection Product for the Knee
2. Dignitas Personae, Vatican Instruction on Bioethics, Welcomed for Guidance on Issues of Procreation, Medical Research
3. Betty Whites Video States Support for Funding Humane Research to Help Pets and Wild Animals - Actress is 40-Year Champion of Morris Animal Foundation
4. The American Federation for Medical Research Says Daschle Must Cure Clinical Research Crisis if Change Is To Take Hold in U.S. Health Care System
5. Mayo Clinic researchers find tamoxifens power comes from endoxifen
6. LATH wins contract to boost health research capacity in Malawi
7. University of Minnesota receives $40 million for type 1 diabetes research
8. Dr. Ben Berkhout awarded Retrovirology Prize for contribution to HIV research
9. Researcher Receives Free Flow Cytometer System as First Winner of Accuri(R) Flow Cytometer Creativity Awards Program
10. New Poll Warns Daschle, Obama: Mandatory Health Insurance Big Loser With Public; Voters Want Return on Stem Cell Research
11. Seven life scientists get research boost to set up in Europe
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research Explains Benefit of 'Mini Heart Attack'
(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... ... 24, 2016 , ... Those who have experienced traumatic events may suffer from ... avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid this ... coping following a traumatic event. , Trauma sufferers tend to feel a range of ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
(Date:6/24/2016)... ... 2016 , ... Comfort Keepers® of San Diego, CA is excited to announce ... program to drive cancer patients to and from their cancer treatments. Comfort Keepers ... of life and ongoing independence. Getting to and from medical treatments is one ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Bay ... Rehabilitation Network,s Dean Center for Tick Borne ... Medicine and Rehabilitation, MIT Hacking Medicine, University of ... Innovation, today announced the five finalists of ... Lyme disease.  More than 100 scientists, clinicians, researchers, ...
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
Breaking Medicine Technology: