Navigation Links
Research: Lupus drugs carry no significant cancer risk for patients
Date:1/24/2013

This press release is available in French.

Montreal, January 24, 2013 People who take immunosuppressive drugs to treat lupus do not necessarily increase their cancer risk according to new research led by scientists at the Research Institute of the McGill University Health Centre (RI-MUHC). This landmark study, which was published in Annals of the Rheumatic Diseases this month, addresses long-standing fears of a link between lupus medication and cancer.

Systemic lupus erythematosus (SLE), commonly known as lupus, is an autoimmune disease in which the body's immune system attacks healthy tissue such as the skin, joints, kidneys and the brain, leading to inflammation and lesions. The disease affects about 1 in 2000 Canadians, particularly women.

Previous research has suggested that lupus patients have an increased risk of developing cancer, particularly lymphoma. Lymphoma is a type of blood cancer that occurs when cells called lymphocytes, which usually help protect the body from infection and disease, begin growing and multiplying uncontrollably leading to tumor growth.

"Treatment for Lupus consists largely of immunosuppressive medications, which lower the body's immune response," explains Dr. Sasha Bernatsky, first and corresponding author of the study, who is a researcher within the Divisions of Clinical Epidemiology and Rheumatology at the RI-MUHC and at McGill University.

According to Dr. Ann E. Clarke, director of the MUHC lupus clinic and study co-lead, the fear of developing cancer among Lupus patients has been so great that some were reluctant to take their medication and others stopped altogether. The international study involved 75 lupus patients with lymphoma from different centres around the world and nearly 5,000 cancer-free lupus patients as a control.

Researchers studied most of the drugs commonly used to treat SLE including cyclophosphamide, a drug reserved for severe lupus cases and other chronic inflammatory rheumatic diseases.

The results showed that the risk for lymphoma in lupus patients exposed to cyclophosphamide was less than 0.1% per year. In addition, no clear association was observed between lupus disease activity and lymphoma risk.

"People have been wondering for a long time whether the medications were to blame and the results are reassuring, suggesting that most lymphoma cases in SLE are not triggered by drug exposures," says Dr. Bernatsky.

"This is very good news that cancer risk associated with lupus medication is relatively low," said Louise Bergeron, who has been living with lupus for 12 years.

"It reassures me, especially if I need to take more effective immunosuppressive treatments in the coming years."

Future research will focus on the genetic profiles of lupus patients and what impact that can have on the interaction between medication exposure and lymphoma risk in lupus.


'/>"/>
Contact: Julie Robert
julie.robert@muhc.mcgill.ca
514-934-1934 x71381
McGill University Health Centre
Source:Eurekalert

Related medicine news :

1. Breast stem-cell research: Receptor teamwork is required and a new pathway may be involved
2. BioMed Central presents Challenges in Malaria Research: Progress Towards Elimination
3. Research: NCAA football exploits players in invisible labor market
4. Kinsey research: Postpartum women less stressed by threats unrelated to the baby
5. New Guidelines Issued for Severe Lupus
6. Chronic exposure to staph bacteria may be risk factor for lupus, Mayo study finds
7. Belimumab for lupus erythematosus: Added benefit not proven
8. Women with lupus have a higher risk for preeclampsia
9. Lupus May Be Linked to Serious Pregnancy Complication
10. Researchers identify impact of rheumatoid arthritis and lupus on joint replacement surgery outcomes
11. Michigan Lupus Foundation: New Name, Same Great Services
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... ... is pleased to welcome new Partner Firm Austin & Co., Inc. Headquartered ... to insurance, employee benefits, HR consulting, benefits technology, and beyond. As an ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... How to ... · Raleigh, NC, http://www.fdanews.com/humanerrordrugdevice , Human error is known to be the ... that human error will ever be totally eliminated, many human performance problems can be ...
(Date:5/24/2016)... — , ... (PRWEB) ... of three new members of its Advisory Board. Joining the ... Sarah Kusch. “All three of them embody the mission of our ... are very fortunate to have them as we continue to expand ...
(Date:5/24/2016)... ... May 24, 2016 , ... Backed by ... logger for each job, ensuring the best suited solution to meet regulatory requirements. ... loggers at their lab in Istanbul. , Metroloji Okulu specializes in MadgeTech’s line ...
(Date:5/24/2016)... ... May 24, 2016 , ... The Radiosurgery Society ... of radiosurgery, is recognizing five medical residents and students for their outstanding contributions ... (SBRT). The awards will be presented at the 2016 SRS/SBRT Scientific Meeting taking ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... May 24, 2016  Diana Russell suffers from a ... from the inside out.  This disease has put her ... her children and grandchildren to leave her home.  Because ... family cannot haul the wheelchair.  So if there is ... and Diana is left to wait for the bus. ...
(Date:5/24/2016)... Celsion Corporation (NASDAQ: CLSN ... an update on its ongoing OVATION study, a ... the Company,s DNA-based immunotherapy, with the standard of ... advanced ovarian cancer who will undergo neoadjuvant chemotherapy ... IL-12 DNA plasmid vector formulated as a nanoparticle ...
(Date:5/24/2016)... , May 24, 2016 ... de doble terapia del mundo, introduce catéteres para ... OrbusNeich, una compañía global especializada en ... vidas, ha expandido su cartera incluyendo productos para ... JADE™ y Scoreflex™ PTA son los dispositivos de ...
Breaking Medicine Technology: