Navigation Links
Research: Chemoresponse assay helps boost ovarian cancer survival
Date:4/25/2013

This spring, a team of researchers has released results from an eight-year study that shows improved survival rates for women diagnosed with ovarian cancer who undergo cancer tumor testing to determine the best treatment.

Part of the team was Richard G. Moore, MD, director of the Center for Biomarkers and Emerging Technologies and a gynecologic oncologist with the Program in Women's Oncology at Women & Infants Hospital of Rhode Island.

"Essentially, we have demonstrated that by using a tissue sample from the patient's tumor and a chemoresponse assay, we are able to determine which treatment may or may not work for her," Dr. Moore explains of the study, which was presented at a recent meeting of the Society of Gynecologic Oncology and in the trade publication Cure.

"This study shows that a woman with recurrent ovarian cancer could benefit from having a biopsy and chemosensitivity testing. The results from such testing will allow for the identification of chemotherapeutics that are active against the patient's disease and those that are not resulting in decreased toxicity from ineffective treatments. Learning that personal directed therapies may improve overall survival for these patients made this the first study in two decades to show a significant increase in survival in recurrent ovarian cancer."

The study, launched in 2004, included 283 women. Of those, 262 had successful biopsies which were tested in vitro, or in a test tube. The assay ChemoFx, by Precision Therapeutics, tested up to 15 approved treatment regimens on the samples, identifying chemotherapy drugs and regimens to which each tumor might be sensitive. The study was non-interventional, meaning that physicians chose the treatment regimens without knowing of the assay results. The researchers then evaluated the assay's result against actual patient outcomes.

"The assay identified at least one treatment to which the tumor would be sensitive in 52% of patients in the study," Dr. Moore says. "Overall, median survival was 37.5 months for patients with treatment-sensitive tumors, compared to 23.9 months for intermediate and resistant tumors."

Assay-directed therapy has long been debated among oncologists, he continues. Such debate provided the impetus for this study.


'/>"/>

Contact: Susan McDonald
slmcdonald@wihri.org
401-681-2816
Women & Infants Hospital
Source:Eurekalert

Related medicine news :

1. Breast stem-cell research: Receptor teamwork is required and a new pathway may be involved
2. BioMed Central presents Challenges in Malaria Research: Progress Towards Elimination
3. Research: NCAA football exploits players in invisible labor market
4. Kinsey research: Postpartum women less stressed by threats unrelated to the baby
5. Research: Lupus drugs carry no significant cancer risk for patients
6. Research: Military women may have higher risk for STIs
7. Gut microbiota research: Pinpointing a moving target
8. Research: Brain cant cope with making a left-hand turn and talking on hands-free cell phone
9. UTHealth research: Low incidence of venous insufficiency in MS
10. Multiple sclerosis research: The thalamus moves into the spotlight
11. Research: Women over 40 still need effective contraception
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... , ... April 29, 2016 , ... ... awareness for Duchenne muscular dystrophy, and funding for Duchenne research, participated in the ... of the Sarepta Therapeutic’s novel Duchenne drug eteplirsen. The meeting at the Marriott ...
(Date:4/29/2016)... ... 29, 2016 , ... Intellitec Solutions will be a sponsor ... at the Broward County Convention Center. The event is a chance for finance ... in public facility management. Intellitec Solutions will highlight their customized accounting solutions designed ...
(Date:4/29/2016)... CA (PRWEB) , ... April 29, 2016 , ... Pro3rd ... X. Utilize Pixel Film Studios’ lower thirds to introduce people, characters, and locations without ... that include boxes, lines, accents, textures and many more design components. Simply select a ...
(Date:4/29/2016)... ... April 29, 2016 , ... The number of chronically and seriously ill individuals ... there is an urgent need for highly skilled care managers and care coordinators. ... approach to train and retain care managers, and enhance their skills. , ...
(Date:4/29/2016)... PA (PRWEB) , ... April 29, 2016 , ... ... and providers, recently announced that their founders, Dr. Gemmi and Dr. Middleberg, were ... over 550 orthodontists around the nation. During the seminar, titled “Advancing the ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... , Schweiz, April 27, 2016 /PRNewswire/ ... des Sachs CEO Forums in Zürich gab ... ihres führenden Wirkstoffkandidaten STR001 zur Erhaltung des ... eingesetzt wurde, bekannt. Für die umfassende Phase-II-Doppelblindstudie ... und Frankreich angeworben. STR001 wird während der ...
(Date:4/27/2016)... Transparency Market Research has published ... Global Industry Analysis, Size, Share, Growth, Trends, and Forecast ... skincare devices market was valued at US$ 7,255.8 Mn ... CAGR of 10.1% from 2015 to 2023 to reach ... full Skincare Devices Market (Treatment Device - LED Therapy Devices, ...
(Date:4/27/2016)... Shire plc (LSE: SHP, NASDAQ: SHPG ... will present at the Deutsche Bank 41st Annual Health Care ... May 04, 2016, 10:00 am EDT (15:00 BST). ... and Webcasts section of Shire,s Investor website at http://investors.shire.com/presentations-and-webcasts/ ... on this same website for approximately 90 days. ...
Breaking Medicine Technology: