Navigation Links
Reprogramming brain cells important first step for new Parkinson's therapy
Date:12/13/2011

ed neurons grow and make connections, reducing symptoms for a time. Ethical issues about the source of embryonic stem cells; the interaction of cells with host cells; the efficiency of stems cells to reproduce, and their long-term viability and stability are all still concerns about trials using dopaminergic cell transplants to treat Parkinson's.

First Steps

In the first step towards a direct cell replacement therapy for Parkinson's, the team reprogrammed astrocytes to dopaminergic neurons using three transcription factors ASCL1, LMX1B, and NURR1 delivered with a lentiviral vector.

The process is efficient, with about 18 percent of cells expressing markers of dopaminergic neurons after two weeks. The next closest conversion efficiency is approximately 9 percent, which was reported in another study.

The dopamine-producing neurons derived from astrocytes showed gene expression patterns and electrophysiolgical properties of midbrain dopaminergic neurons, and released dopamine when their cell membranes were depolarized.

The Penn team is now working to see if the same reprogramming process that converts astrocytes to dopamine-producing neurons in a dish can also work within a living brain experiments will soon be underway using gene therapy vectors to deliver the reprogramming factors directly to astrocytes in a monkey model of PD.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Discovery of a new reprogramming mechanism for tumor cells
2. Gadgets not related to teenagers brain pain
3. Dementia Rates Escalate as Brain Capacity Diminishes with Age
4. Researchers discover new way to kill pediatric brain tumors
5. Scientists Pinpoint Area of Brain That Fears Losing Money
6. Physical Changes in Brain Linked to Altered Spirituality
7. Pro Athletes Brains React at Olympic Speed
8. Neuroscientists reveal new links that regulate brain electrical activity
9. Brain Scan Shows What Beauty is Worth
10. Study supports alternative anti-seizure medication following acute brain injury
11. Exercise helps protect brain of multiple sclerosis patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Reprogramming brain cells important first step for new Parkinson's therapy
(Date:9/19/2014)... FRIDAY, Sept. 19, 2014 (HealthDay News) -- When it ... deaths in the United States, while the District of ... Over the past decade, deaths from gun-related violence -- ... across the United States, the study revealed. Hawaii,s rate ... end of the spectrum, the District of Columbia had ...
(Date:9/19/2014)... Majidi, M.D., a second-year resident in the Department ... of Medicine and Health Sciences, received at $154K ... the presence of diffuse brain swelling and injury ... to epidemiological studies, intracerebral hemorrhage accounts for less ... the least treatable form of stroke, with the ...
(Date:9/19/2014)... 2014 Top 10 Best SEO ... that HostGator.com, GoDaddy and Bluehost are among the ... are the most recommended suppliers for webmasters from ... buy high quality Linux hosting (including VPS and ... one of many top hosting companies that started ...
(Date:9/19/2014)... Capital Region Periodontics and Dental ... to announce the latest addition to their treatment ... those needing dental implants. Often referred to as ... the fear factor normally associated with traditional gum ... bleeding make, this procedure a very attractive oral ...
(Date:9/19/2014)... Many patients with advanced, incurable cancer do not receive ... later this month at the ESMO 2014 Congress in ... they come at the same time as 15 new ... are being awarded the prestigious title of ,ESMO Designated ... I Dr Alexandru Grigorescu, medical oncology consultant at the ...
Breaking Medicine News(10 mins):Health News:U.S. Gun Deaths Lowest in Hawaii, Highest in D.C. 2Health News:GW researcher receives grant to study brain swelling following bleeding in the brain 2Health News:Top10BestSEOHosting.com Announces Great Linux Web Hosting Suppliers In 2014 2Health News:Albany, NY Periodontist Reed Ference, DMD, Calms Fears of Patients with Gum Disease by Offering LANAP®, An Advanced, Less Invasive Treatment Solution 2Health News:Albany, NY Periodontist Reed Ference, DMD, Calms Fears of Patients with Gum Disease by Offering LANAP®, An Advanced, Less Invasive Treatment Solution 3Health News:Patients with advanced, incurable cancer denied palliative care 2Health News:Patients with advanced, incurable cancer denied palliative care 3Health News:Patients with advanced, incurable cancer denied palliative care 4
... March 31, John Wiley & Sons, Inc. (NYSE: JWa, ... psychology, entitled Putting Research into Practice. The invitation-only forum, ... Development Biennial Meeting in Montreal, was a dynamic discussion ... developmental psychology more accessible. The Company, through its ...
... , WEDNESDAY, April 6 (HealthDay News) -- Poor ... have the condition diagnosed, but this disparity has decreased in ... data on children in California and found that the average ... born in 1992 to 3.8 years for those born in ...
... , This release is available in French ... Libya. Revolution in Egypt. Revolution in Tunisia. The Middle East ... people clamor for democracy. Yet it remains unclear ... The reshaping of societies raises fundamental questions that require monumental ...
... published in the scientific journal Cell Metabolism , shows ... In a series of experiments on mice, which had the ... the animals soon demonstrated a reduced ability to regulate their ... immediate changes; the mice started to eat more and became ...
... 2011 When the U.S. Preventive Services Task Force ... and prevention, released its recommendations on mammography screenings for ... and considerable controversy. In a study published in the ... Preventive Medicine , investigators report that these new recommendations ...
... expecting to find such high levels of PCBs, highly toxic ... in a region such as the western coast of Africa", ... Country (UPV/EHU-Spain) and co-author of a study published in the ... PCBs, which some studies have shown to be carcinogenic compounds, ...
Cached Medicine News:Health News:Wiley hosts developmental psychology roundtable at SRCD 2Health News:Autism Diagnoses Still More Likely in Richer Neighborhoods 2Health News:What the world needs now? More wisdom 2Health News:What the world needs now? More wisdom 3Health News:New discovery proves cause of weight problems in Huntington's disease 2Health News:Most recent mammography recommendations confuse public 2Health News:Most recent mammography recommendations confuse public 3Health News:High levels of toxic compounds found on coasts of West Africa 2
(Date:9/18/2014)... -- According to the new research ... Warming & Cooling), Application (Acute & Perioperative Care, ... & Paramedical Staff) - Global Forecasts & Trends ... global Temperature Management Market over the forecast period ... to reach $2.5 Billion by 2019 at CAGR ...
(Date:9/18/2014)... This BCC Research report discusses the medical device technologies ... and size, and opportunities for different devices and regions. It ... analysis in the report focuses on technological trends in recent ... and Japan . ... global medical device technologies market. - Analyze market structure, including ...
(Date:9/18/2014)...   Fruit Street Health (Fruit Street), today ... of funding. The round, which includes ... of individual investors, the majority of whom are prominent ... round are; Houston Cardiology Consultants Partner Asif Ali, ... Rapha Family Medicine Practice Owner Frances Ilozue , ...
Breaking Medicine Technology:Temperature Management Market Worth $2.5 Billion by 2019 2Temperature Management Market Worth $2.5 Billion by 2019 3Temperature Management Market Worth $2.5 Billion by 2019 4Medical Devices: Technologies and Global Markets 2Medical Devices: Technologies and Global Markets 3Medical Devices: Technologies and Global Markets 4Fruit Street Health Secures First Round Of Seed Funding Led By Group Of Medical Industry And Technology Leaders 2Fruit Street Health Secures First Round Of Seed Funding Led By Group Of Medical Industry And Technology Leaders 3
... Calif. , May 24 Hisamitsu, a world leader in the manufacture of external ... ® P AIN RELIEF PATCH ... , , ... Both SALONPAS® PAIN RELIEF ...
... Volcano Corporation (Nasdaq: VOLC ) announced today the company,s plans to ... breaking trials during EuroPCR from May 25 – 28 in ... "Through both imaging and ... meet the complex needs of the interventional vascular physician and their patients," said ...
Cached Medicine Technology:Hisamitsu Pharmaceutical Announces Two New FDA Approved Over-The-Counter Pain Relief Patches 2Volcano Announces Plans to Introduce Multiple New Products at EuroPCR 2010 2Volcano Announces Plans to Introduce Multiple New Products at EuroPCR 2010 3Volcano Announces Plans to Introduce Multiple New Products at EuroPCR 2010 4Volcano Announces Plans to Introduce Multiple New Products at EuroPCR 2010 5
Disposable Microscissors: Horizontal, Curved...
Sharp tipped scissors with a vertical cutting action. Rounded lower edge of scissors blade minimizes unintentional engagement of retina....
Low profile, sharp-tipped scissors with a vertical cutting action. Excellent for peeling and cutting fine epiretinal membranes....
Sharp tipped scissors with a curvature of 12 mm to follow the contour of the retina. For cutting in the plane parallel to the retina, cutting membranes adherent to the retinal surface and all purpose...
Medicine Products: