Navigation Links
Reprogrammed Cells Reduce Parkinson's Symptoms
Date:4/7/2008

Rodent studies could lead to therapeutic applications in humans, researchers say

MONDAY, April 7 (HealthDay News) -- Transplanted neurons derived from reprogrammed adult skin cells successfully integrated into the brains of fetal mice and reduced symptoms of a Parkinson's disease-like condition in adult rats, say U.S. researchers.

"This is the first demonstration that reprogrammed cells can integrate into the neural system or positively affect neurodegenerative disease," study author Marius Wernig, a postdoctoral researcher at the Whitehead Institute for Biomedical Research in Cambridge, Mass., said in a prepared statement.

The induced pluripotent stem (IPS) cells were created by reprogramming adult skin cells using retroviruses that expressed four genes (Oct4, Sox2, c-Myc and Klf4) into the cells' DNA. The IPS cells were then differentiated into neural precursor cells and dopamine neurons.

In one experiment, the neural precursor cells were transplanted into the brains of mouse embryos. When the researchers analyzed the mice nine weeks after birth, they found the transplanted cells had formed clusters at the area they'd been injected and then migrated into surrounding brain tissue.

The researchers also found the migrating neural precursor cells had differentiated into several subtypes of neural cells and had functionally integrated into the brain.

In another experiment, differentiated dopamine neurons were grafted into the brains of rats in which the dopamine-producing neurons on one side of the brain had been destroyed. This is a model of Parkinson's disease in humans, which is caused by insufficient levels of dopamine.

Four weeks after the surgery, eight of the nine rats that received the dopamine neuron transplants showed improvement. Eight weeks after transplantation, the dopamine neurons had extended into the surrounding brain tissue.

The study was published in this week's online issue of the Proceedings of the National Academy of Sciences.

While this work shows promise, much more research needs to be done before there's any likelihood that it will lead to new treatments for humans.

More information

We Move has more about Parkinson's disease.



-- Robert Preidt



SOURCE: Whitehead Institute, news release, April 7, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Identification of dopamine mother cells could lead to future Parkinsons treatments
2. Leaky blood vessels open up nerve cells to toxic assault in Lou Gehrigs disease
3. Nanomachine Releases Anticancer Drugs Inside Cells
4. Fetal Cells Detected in Mothers Blood Years After Donor Egg Pregnancies
5. Fasting Before Chemo Protects Healthy Cells
6. UCLA researchers design nanomachine that kills cancer cells
7. Scientists Uncover How HIV Hides Inside Cells
8. Stem cells from hair follicles may help grow new blood vessels
9. Researchers Create Protective Sac for Growing Stem Cells
10. Cells from the Research Institute of the MUHC on the road to China
11. Scientists learn whats up with a class of retinal cells in mice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Reprogrammed Cells Reduce Parkinson's Symptoms 
(Date:5/22/2017)... ... May 22, 2017 , ... OSF ... group investing in InsightRX, an early stage company in San Francisco that has ... characteristics. Greatpoint Ventures Innovation Fund acted as the lead investor in ...
(Date:5/21/2017)... ... May 20, 2017 , ... GetLinked® ... Services and financial systems. , Dozens of clubs using ABC Financial Services ... processed through GetLinked into their club’s accounting system , The latest implementation is ...
(Date:5/21/2017)... ... May 21, 2017 , ... For the past ... group of scholars, policymakers, and activists wanting to address equity issues in breastfeeding, ... the third book from a recent series of from this conference. , ...
(Date:5/21/2017)... PA (PRWEB) , ... May 21, 2017 , ... Following ... 2012, New York became the first state to require that hospitals follow a protocol ... controversy in the medical community as to whether such steps would have saved Rory ...
(Date:5/19/2017)... Charlotte, NC (PRWEB) , ... May 19, 2017 ... ... of the Charlotte health community, Queens University of Charlotte recently began recruitment efforts ... The program’s curriculum arms students with the skills, knowledge and expertise to approach ...
Breaking Medicine News(10 mins):
(Date:5/8/2017)... 8, 2017 MACRA replaces the outdated ... for service reimbursement. Black Book Research crowdsource-surveyed 8,845 physician ... 1.       The Market for MIPS Compliance Technology is Booming ... practices with 3 or more clinicians seek to buy ... "Given the magnitude of the changes, the hunt is ...
(Date:5/6/2017)... -- May is Stroke Awareness Month and Omron Healthcare is ... to prevent a stroke: monitor and manage your blood ... Prevention, undetected and uncontrolled hypertension is a leading risk ... in personal heart health technology, recently evolved its mission ... stroke and is advancing a national public education effort ...
(Date:5/4/2017)... May 4, 2017  A recent study published ... Ultraviolet-C light as a means of disinfection ... to reduce bioburden on anesthesia workstations. In the ... high-touch, complex medical equipment surfaces contaminated with three ... "This study further validates the body of ...
Breaking Medicine Technology: