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TABLE 21 EXISTING TREATMENTS: HUNTINGTON'S DISEASE 57

Demographics (Continued) 58

Treatment 59

TABLE 22 TREATMENT FORECAST FOR HUNTINGTON'S DISEASE, THROUGH 2014 ($ MILLIONS) 60

FIGURE 7 TREATMENT FORECAST FOR HUNTINGTON'S DISEASE, 2007-2014 ($ MILLIONS) 61

HIV-RELATED MEMORY AND COGNITION EFFECTS 61

TABLE 23 WORLDWIDE DISEASE PREVALENCE: HIV-RELATED (%) 62

TABLE 24 EXISTING TREATMENTS: HIV-RELATED 63

TABLE 25 TREATMENT FORECAST FOR HIV-RELATED, THROUGH 2014 ($ MILLIONS) 63

FIGURE 8 TREATMENT FORECAST FOR HIV-RELATED, 2007-2014 ($ MILLIONS) 64

GENETIC DISEASES 64

TABLE 26 WORLDWIDE DISEASE PREVALENCE: GENETIC DISEASES (%) 64

TABLE 27 EXISTING TREATMENTS: GENETIC DISEASES 65

TABLE 28 TREATMENT FORECAST FOR GENETIC DISEASES: COGNITION ONLY, THROUGH 2014 ($ MILLION) 65

FIGURE 9 TREATMENT FORECAST FOR GENETIC DISEASES, 2007-2014 ($ MILLIONS) 66

Pick's Disease 66

Krabbe Disease 67

Krabbe Disease (Continued) 68

Chapter-4: MECHANISMS OF ACTION

MECHANISMS OF ACTION 69

TABLE 29 MARKETED TREATMENTS: ALL DISEASES 70

COMMON MECHANISMS 71

CHOLINESTERASE INHIBITORS 71

TABLE 30 CHOLINESTERASE INHIBITORS 71

NMDA Antagonists 71

TABLE 31 NMDA ANTAGONISTS 72

Nicotinics 72

TABLE 32 NICOTINIC ACETYLCHOLINE ANTAGONISTS 73

Calcineurins 73

TABLE 33 CALCINEURINS 73

GABA Modulators 74

TABLE 34 ANTI-EPILEPTIC/GABA MODULATORS 74

Hormones 75

TABLE 35 HORMONES 75

OTHER MECHANISMS 75

COGNITION ENHANCERS IN DEVELOPMENT 76

DRUGS FOR DISEASE MODIFICATION 76

Secretase Inhibitors 76

Metal Chelation 76

Vaccines 76

Statins 76

Neurotransmitter Targets 77

NSAIDS 77

Antioxidants 77'/>"/>