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Repligen Reports Second Quarter Fiscal Year 2008 Financial Results
Date:11/8/2007

>Intellectual Property

ImClone Litigation Settlement

In September, we announced settlement with ImClone Systems, Incorporated (ImClone) in the lawsuit against ImClone for infringement of U.S. Patent No. 4,663,281 based on ImClone's manufacture and sale of Erbitux(R). The settlement provided for ImClone to pay $65 million to co-plaintiffs Repligen and The Massachusetts Institute of Technology (MIT) which resulted in net proceeds to Repligen of approximately $40 million after payment of obligations to MIT and legal expenses.

CTLA4-Ig Patent

In 2006, Repligen and The University of Michigan filed a lawsuit against Bristol-Myers Squibb (Bristol) for infringement of a U.S. patent that covers a method of treating rheumatoid arthritis with CTLA4-Ig. Bristol markets CTLA4- Ig for treatment of rheumatoid arthritis, under the brand name Orencia(R). Recently, the Court held a Markman hearing in order to interpret the meaning of the claims in the patent. In its ruling on claims construction, the Court rejected Bristol's attempt to insert a mechanistic limitation on the use of CTLA4-Ig for the treatment of rheumatoid arthritis and accepted our straightforward reading of the claim. We anticipate that Summary Judgment briefing will be complete in February and a trial will occur in April.

Quarterly Conference Call

Walter C. Herlihy, Ph.D., will host a conference call and webcast on Thursday, November 8th at 11:00 a.m. EST, to review second quarter fiscal year 2008 financial results and expectations and provide a quarterly update of the Company. This call is being webcast and can be accessed via Repligen's website at http://www.repligen.com or you may also listen to the live broadcast by calling (800) 591-6945 for domestic calls and (617) 614-4911 for international calls. Participants must provide the following passcode: 91810104. For those who cannot participate in the live conference call, an ar
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