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Repligen Reports Second Quarter Fiscal Year 2008 Financial Results
Date:11/8/2007

arter of 2008. We believe there may be more than 100,000 pancreatic MRI imaging procedures conducted in the U.S. each year that could benefit from the use of secretin.

Uridine for Bipolar Disorder

Today we reported the results from our Phase 2 clinical trial of RG2417, an oral formulation of uridine, in bipolar disorder. This was a multi-center study in which 84 patients received RG2417 or a placebo over a 6-week period. The objective of the study was to assess the safety and efficacy of RG2417 on the symptoms of bipolar depression as measured by the co-primary endpoints, the Montgomery-Asberg Depression Rating Scale (MADRS) and the Clinical Global Impression of Change in Bipolar Disorder scale (CGI-BP-C). Patients were evaluated at baseline and then weekly using these standardized tools to assess change in their symptoms. Over the six-week treatment period, the study demonstrated a statistically significant improvement in the symptoms of depression in the patients receiving RG2417 when compared to placebo on the MADRS (p=0.03) and a strong trend toward improvement on the CGI-BP-C (p=0.06). This study was conducted under a development agreement with the Stanley Medical Research Institute.

Transcription Activators for Friedreich's Ataxia

In April, we acquired the rights to intellectual property covering compounds which may have utility in treating Friedreich's ataxia. We have synthesized and evaluated more than 100 compounds for their activity and have identified several with improved potency and specificity. We are continuing to evaluate this family of compounds for activity in animal models of Friedreich's ataxia and other neurodegenerative diseases. In September, we received a $100,000 research grant from the Friedreich's Ataxia Research Alliance (FARA) to support some of the research activities. FARA is a non- profit organization dedicated to the pursuit of scientific research leading to treatments and a cure for Friedreich's ataxia.

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