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Replidyne Pipeline Featured at 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy

icile program. The presentation introduced REP3123, highlighting key preclinical findings including its ability to inhibit growth, halt toxin production and prevent spore-formation of the Gram-positive C. difficile bacterium without inhibiting other key organisms that are essential for normal intestinal functioning.

Replidyne will present the following C. difficile posters on Thursday, September 20 at 10:00 AM, Room E253D:

-- Poster F1-2112, titled "Novel Inhibitors of Methionyl tRNA Synthestase

from Clostridium difficile: Identification and Synthesis of REP3123."

-- Poster F1-2113, titled "REP3123 is a Potent and Selective Inhibitor of

Methionyl tRNA Synthetase from Clostridium difficile."

-- Poster F1-2114, titled "Co-crystal Structure of REP3123 Bound to

Clostridium difficile Methionyl tRNA Synthetase."

-- Poster F1-2115, titled "Spectrum of Activity of REP3123 against

Aerobic Bacterial Pathogens."

-- Poster F1-2117, titled "In vitro Activity of REP3123 against

Clostridium difficile and Other Anaerobic Intestinal Bacteria."

-- Poster F1-2118, titled "REP3123: A Narrow Spectrum Antibacterial Agent

that Inhibits Growth and Prevents Sporulation in Clostridium


-- Poster F1-2119, titled "REP3123 Inhibits Toxin Production in C.


-- Poster F1-2120, titled "Efficacy of Novel MetRS Inhibitors in a C.

difficile Hamster Model."

Faropenem Presentations

Monday, September 17 at 12:00 PM, Hall D:

-- Poster E-256, titled "Comparison of the Bactericidal Activities of

Faropenem, Ertapenem, Amoxicillin, Cefixime, Cefuroxime and

Moxifloxacin against Streptococcus pneumoniae."

-- Poster E-257, titled "Comparative Ability of Faropenem to Select for

Resistant Mutants of S. pneumoniae."

-- Poster E-258, titled "Comparative Ability of Faropenem to Sele

SOURCE Replidyne, Inc.
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