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Replidyne Pipeline Featured at 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
Date:9/17/2007

icile program. The presentation introduced REP3123, highlighting key preclinical findings including its ability to inhibit growth, halt toxin production and prevent spore-formation of the Gram-positive C. difficile bacterium without inhibiting other key organisms that are essential for normal intestinal functioning.

Replidyne will present the following C. difficile posters on Thursday, September 20 at 10:00 AM, Room E253D:

-- Poster F1-2112, titled "Novel Inhibitors of Methionyl tRNA Synthestase

from Clostridium difficile: Identification and Synthesis of REP3123."

-- Poster F1-2113, titled "REP3123 is a Potent and Selective Inhibitor of

Methionyl tRNA Synthetase from Clostridium difficile."

-- Poster F1-2114, titled "Co-crystal Structure of REP3123 Bound to

Clostridium difficile Methionyl tRNA Synthetase."

-- Poster F1-2115, titled "Spectrum of Activity of REP3123 against

Aerobic Bacterial Pathogens."

-- Poster F1-2117, titled "In vitro Activity of REP3123 against

Clostridium difficile and Other Anaerobic Intestinal Bacteria."

-- Poster F1-2118, titled "REP3123: A Narrow Spectrum Antibacterial Agent

that Inhibits Growth and Prevents Sporulation in Clostridium

difficile."

-- Poster F1-2119, titled "REP3123 Inhibits Toxin Production in C.

difficile."

-- Poster F1-2120, titled "Efficacy of Novel MetRS Inhibitors in a C.

difficile Hamster Model."

Faropenem Presentations

Monday, September 17 at 12:00 PM, Hall D:

-- Poster E-256, titled "Comparison of the Bactericidal Activities of

Faropenem, Ertapenem, Amoxicillin, Cefixime, Cefuroxime and

Moxifloxacin against Streptococcus pneumoniae."

-- Poster E-257, titled "Comparative Ability of Faropenem to Select for

Resistant Mutants of S. pneumoniae."

-- Poster E-258, titled "Comparative Ability of Faropenem to Sele
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SOURCE Replidyne, Inc.
Copyright©2007 PR Newswire.
All rights reserved

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