Navigation Links
Replication at DNA damage sites highlights Fanconi anemia and breast cancer proteins
Date:9/10/2009

scientists have been following for many years is that all 13 genes must work together to deal with DNA crosslinks, that there must be some kind of cascade or chain reaction," Li said. "We developed a new genetic technique to look specifically at what proteins are present at the crosslinks."

New method yields answers

Using this new tool, researchers found that all the FA genes are present in the site of a crosslink. This is the first time FA proteins have been linked directly with DNA crosslinking damage at the molecular level.

"The surprise is that the breast cancer proteins, although they are present at crosslinks, must have DNA replication at the crosslinks," Li said. "If there is a DNA lesion on the genome but no DNA replication, the canonical FA proteins are used to deal with the damage. The breast cancer-related FA proteins are taking care of the DNA lesion that stops DNA replication."

Li said this leads to a new paradigm that there must be two separate subgroups or subpathways within the 13 FA genes.

"The major implication of this study is that now we have a new working model," Li said. "This provides a new direction for future research of breast cancer proteins and DNA damage response in general.

"Our next step is to continue to look at how FA proteins and the subgroup of breast cancer-related proteins help protect cells from DNA crosslink damage. And, in a more general sense, how these cellular mechanisms eventually may help us minimize mutations that ultimately lead to cancer."


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Childrens Hospital Boston Deploys AutoVirt Solution to Increase Speed and Efficiency of Windows Data Replication
2. Compounds that trigger beta cell replication identified by JDRF funded researchers
3. Burnham researchers illuminate mechanisms that regulate DNA damage control and replication
4. Herpes drug inhibits HIV replication, but with a price
5. New Compound Slows HIV Replication
6. New agent strikes at respiratory syncytial virus replication
7. Health and Pension Benefits Provider Turns to Xiotechs TimeScale Replication Services to Protect Critical Data
8. FDA Investigating Weight-Loss Drug Over Reports of Liver Damage
9. Pot Might Blunt Damage of Binge Drinking
10. Blood test can detect brain damage in amateur boxers
11. DEET in Bug Spray Tied to Neural Damage in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... 2014 Crosley Law Firm is proud to ... have been named to the list of Super Lawyers in ... of personal injury law. , Before receiving the designation ... selection process. First, they must come highly recommended by a ... noteworthy achievement during the past year by obtaining certain honors, ...
(Date:9/15/2014)... Imaging can be a cost-effective way ... benefit from aggressive intervention, according to a new modeling ... The study looked at people with asymptomatic carotid artery ... blood to the head due to atherosclerosis, or plaque ... up to 20 percent of ischemic strokes, which result ...
(Date:9/15/2014)... Authors Christine Snow and Donna Albury highlight ... four alcoholics. Born out of love and pain and the ... In The Life... ” (published by Xlibris) reveals the struggles ... from the same fate. , Night life is popular ... in this. This book chronicles a typical night in the ...
(Date:9/15/2014)... researchers at the University of Copenhagen have gained ... Parkinson,s disease. The findings have recently been published ... , The defining symptoms of Parkinson,s disease ... is currently no cure for the condition, so ... the potential to shed some light on this ...
(Date:9/15/2014)... 2014 DISCcert, a San Diego based ... DISC Certification Workshop for Oct 16th and 17th. ... to take part in the intensive and highly regarded ... activities that can be immediately implemented into their business ... to educate employees and staff in DISC skills. Learning ...
Breaking Medicine News(10 mins):Health News:Thomas A. Crosley and R. Andrew Rodriguez Named 2014 Super Lawyers 2Health News:RSNA: Imaging Identifies Asymptomatic People at Risk for Stroke 2Health News:RSNA: Imaging Identifies Asymptomatic People at Risk for Stroke 3Health News:Authors show perils of alcohol abuse in new graphic novel 2Health News:Authors show perils of alcohol abuse in new graphic novel 3Health News:Researchers debunk myth about Parkinson's disease 2Health News:DISCcert Announces Two-day DISC Certification Workshop Oct 16 and 17 2Health News:DISCcert Announces Two-day DISC Certification Workshop Oct 16 and 17 3
... are more likely to have their work cited than ... a new study released this week by Rice University,s ... scientists are also more likely to receive greater recognition ... "International Stem Cell Collaboration: How Disparate Policies Between the ...
... Institute of Technology have found support for the theory that ... it stores readily available items. Memory researchers have long debated ... capacity and function of each layer is. In a ... Cognitive Psychology, researchers found that short-term memory is made ...
... new study of a common etiquetteholding a door for someonesuggests ... motivation: to reduce the work for those involved. The research, ... State University, is the first to combine two fields of ... to be published in a forthcoming issue of Psychological ...
... The Nobel prize-winning physicist Richard Feynman once wrote in his ... "When I see equations, I see letters in colors - ... hell it must look like to the students." This neurological ... of "seeing" the letters in colour was a specific form ...
... significantly impacts quality of life for patients after ... Hospital. "Transplant recipients with alcoholic cirrhosis experienced ... reported greater pain and physical limitations than non-alcoholics ... Ford Behavioral Health Services, lead author of the ...
... MESA, Ariz. March 8, 2011 Predictive Biomarker ... produced by Unibioscreen, kills cancer cells. Previous studies ... MCL1 can cause cancer cells to grow out of ... non-profit, Phoenix-based Translational Genomics Research Institute (TGen), co-discovered that ...
Cached Medicine News:Health News:Report: International collaboration between researchers results in greater recognition 2Health News:New study proves the brain has 3 layers of working memory 2Health News:More reasons to be nice: It's less work for everyone 2Health News:Reading in 2 colours at the same time 2Health News:Alcohol abuse history influences quality of life following liver transplant 2Health News:PBS-Bio uncovers how Unibioscreen drug kills cancer 2
(Date:9/15/2014)... , Sept. 16, 2014  Bayer HealthCare and ... Finland , have begun to ... ODM-201, an investigational oral androgen receptor inhibitor in ... in men with castration-resistant prostate cancer who have ... detectable metastases. The trial is designed to determine ...
(Date:9/15/2014)... Sept. 15, 2014 /PRNewswire/ -  Pivotal Therapeutics Inc. ... pharmaceutical company with a focus on Omega-3 therapies ... that the Board of Directors approved the granting ... advisor at the close of business on Friday, September ... 1,000,000 common shares of the Company were granted ...
(Date:9/15/2014)... Sept. 15, 2014 /PRNewswire-iReach/ -- On September 8, ... South Carolina, submitted a Citizen Petition to Dr. ... FDA to add another Black Box Warning to ... request asks for a Black Box Warning for ... paranoia, suicidal thoughts or acts, loss of consciousness, ...
Breaking Medicine Technology:Bayer and Orion Initiate Phase III Trial of ODM-201 in Men with High-Risk Non-Metastatic Castration-Resistant Prostate Cancer 2Bayer and Orion Initiate Phase III Trial of ODM-201 in Men with High-Risk Non-Metastatic Castration-Resistant Prostate Cancer 3Pivotal Therapeutics Grants Incentive Stock Options 2Quinolone Vigilance Foundation Supports Citizen Petition Requesting Another Black Box Warning for Levaquin, Cipro, Avelox 2Quinolone Vigilance Foundation Supports Citizen Petition Requesting Another Black Box Warning for Levaquin, Cipro, Avelox 3
... , , FARMINGDALE, N.Y., Jan. 8 Misonix, Inc. ... medical device technology, which in Europe is used for the ... has entered into a new, three year distribution agreement with ... Saudi Arabia, for the distribution of the SonaStar(TM) Ultrasonic Surgical ...
... N.Y., Jan. 8 VirtualScopics, Inc. (Nasdaq: VSCP ... trials, announced today that Ms. Molly Henderson, the company,s ... corporate overview at the upcoming OneMedPlace Finance Forum at ... annually, the OneMedPlace Finance Forum was created to connect ...
Cached Medicine Technology:Misonix Announces New Distribution Agreement for Kingdom of Saudi Arabia 2Misonix Announces New Distribution Agreement for Kingdom of Saudi Arabia 3VirtualScopics to Present at the Upcoming OneMedPlace Investment Conference 2VirtualScopics to Present at the Upcoming OneMedPlace Investment Conference 3
... The FoamWrap ACTION Elbow Wrap replaces messy ... players, golfers, and others experiencing epicondylitis. Preferred ... application and non-bulky fit. Two overlay straps ... Breathable, non-slip foam lining holds the Elbow ...
... Brace is designed to handle post-op elbow ... The Bledsoe Extender Arm Brace should be ... of the elbow is desired. In most ... be formed, fitted and adjusted in 5 ...
... lightweight brace allows it to fit easily into ... joint following severe sprains, tendonitis or after cast ... with the ankle and provide optimum medial-lateral support. ... rotational strains on the ankle, and they provide ...
... stretch ankle support helps reduce swelling and minimize ... It is easy to apply - it slips ... fits easily into shoes. It features bilateral ... provide side-to-side support and stability. This is ...
Medicine Products: