Navigation Links
Repairing Injured Lungs May Boost Organ Donations
Date:10/28/2009

Researchers also identify immune cells involved in tissue damage caused by smoking

WEDNESDAY, Oct. 28 (HealthDay News) -- A new type of gene therapy for injured lungs that were previously rejected for transplantation may increase the number of lungs available for transplant, researchers say.

Successful transplants require healthy lungs, but more than 80 percent of donor lungs are highly inflamed and only mildly functional, which means many of them are rejected by surgeons, according to researchers with the University Health Network in Toronto.

The investigators found that infusion with the regulatory gene IL-10 before transplant can heal damaged donor lungs. This procedure involves placing the lungs in a glass chamber outside the body and keeping them breathing using a perfusion system that continuously pumps a solution of oxygen, proteins and nutrients into the lungs.

The study, published in the Oct. 28 issue of Science Translational Medicine, noted that the current method of preserving donor organs is to keep them on ice. But the new lung perfusion system would enable the lung's cellular machinery to keep working by maintaining the lungs at a normal body temperature, the study authors explained in a news release from the journal's publisher.

In one experiment, pig lungs that underwent IL-10 gene therapy and lung perfusion for 12 hours had better function and less swelling when transplanted into recipient pigs. The researchers also found that this treatment produced similar results in human lungs previously rejected for transplant.

Further investigation showed that IL-10 reduced inflammation, refurbished the alveoli (tiny branching sacs where gas exchange occurs), and improved function in the injured donor lungs.

Another study published in the same issue of the journal identified two types of immune cells that play a major role in the destruction of smokers' lungs.

Smoking-related irritation of the lungs triggers a complex immune response that includes an accumulation of different types of immune cells. An analysis of lung tissue from emphysema patients revealed the normally helpful immune cells called dendritic cells travel to the lung and induce T-helper 1 and T-helper 17 cells to destroy lung tissue and proteins responsible for lung elasticity.

The T-helper 17 cells secrete a protein that triggers a reaction that attracts more dendritic cells to the lungs, leading to a repeat of the destructive cycle, the researchers found.

The findings offer more evidence that emphysema (primarily caused by cigarette smoke) is an autoimmune disease. This line of research may lead to new drugs that can control lung damage, the study authors said.

More information

The U.S. National Heart, Lung, and Blood Institute has more about lung transplantation.



-- Robert Preidt



SOURCE: Science Translational Medicine, news release, Oct. 28, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. UD researchers discover promising technique for repairing gene that causes spinal muscular atrophy
2. UD researchers discover technique for repairing gene defect that causes spinal muscular atrophy
3. Proteins essential role in repairing damaged cells revealed
4. Vision restoration therapy shown to improve brain activity in brain injured patients
5. Can brain-injured, partially-blind stroke patients regain some of their lost vision?
6. Imaging Software Helps Track, Treat Injured Brains
7. Novel Cooling Therapy May Have Aided Injured Football Player
8. GPS-like technology helps pinpoint best methods for moving injured players
9. Injured Soldiers at Walter Reed Hospital to Benefit From Congressional Fundraiser
10. Brain measurements could lead to better devices to move injured or artificial limbs
11. In-the-Field Facial Surgery Helps Injured Troops in Iraq
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... 18, 2017 , ... President Donald Trump signed into law ... for greater public access to over-the-counter (OTC) hearing aids. , The measure enables ... without being seen by a certified and licensed audiologist. , “The American ...
(Date:8/19/2017)... ... August 19, 2017 , ... ... a diverse community of over 1,000 passionate employees, caregivers, volunteers, thought leaders, researchers, ... at Stonegate changed ownership, it was time to refresh the carpeting with the ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... Immediate Release                Contact: Julian Teixeira, August 18, 2017                    202-478-8564 / jteixeira@thenc.org , ... from their Fathers , Contrary to a father’s perception, ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... liquid handling handheld devices. Through an educational webinar, they will present the line ... a chance to learn how easy you can automate everyday pipetting tasks. , ...
(Date:8/18/2017)... ... 18, 2017 , ... MLM Insurance Group, a Miami area ... Florida, is working to support the Take Stock In Children Foundation during a ... , The Take Stock In Children Foundation (TSC) offers guidance and assistance to ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Mich. , Aug. 15, 2017 Diplomat ... naloxone to Michigan residents. ... Flint retail pharmacy, G-3320 Beecher ... approved by the Food and Drug Administration, is intended ... extreme drowsiness, slowed breathing, and loss of consciousness. The ...
(Date:8/11/2017)... 11, 2017 DarioHealth Corp. (NASDAQ: DRIO), a ... big data solutions, today announced that it will release ... and host a conference call at 9:00am ET. The ... financial results and its strategy and outlook for the ... Erez Raphael , Chief Executive Officer, and ...
(Date:8/7/2017)... Aug. 7, 2017 Zimmer Biomet Holdings, Inc. (NYSE ... announced that its Board of Directors has approved the payment ... quarter of 2017. The ... or about October 27, 2017 to stockholders of record as ... declarations of dividends are subject to approval of the Board ...
Breaking Medicine Technology: