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Renal risk index: A clinical tool to predict the risk of end-stage renal disease
Date:10/1/2013

Ann Arbor, Mich. End-stage renal disease is one of the major public health problems among solid organ transplant recipients that is associated with death after transplant and high cost of care.

Using the national data of 43,514 liver transplant recipients, researchers at University of Michigan researchers in collaboration with Arbor Research Collaborative for Health created and validated a risk score called renal risk index based upon the liver transplant recipient's characteristics at the time of transplant to predict the post- transplant end stage renal disease. Renal Risk Index was significantly associated with the higher 5-year cumulative incidence of post-transplant end stage renal disease and post-transplant death. The results were published in the Journal of the American Society of Nephrology.

"Our goal was to create a risk score based on the liver transplant recipient's factors to identify those who were at a higher risk of developing post-liver transplant end-stage renal disease," says Pratima Sharma, M.D., M.S., lead author of the study and assistant professor of Internal Medicine in the University of Michigan Medical School.

The renal risk index calculates a score by evaluating several recipient characteristics like age, race/ethnicity, history of hepatitis C, diabetes, BMI, serum creatinine levels and other factors. The renal risk index calculator is available at: https://rri.med.umich.edu.

In addition to previously described risk factors, the study also identified body mass indexes (BMI) over 35 and hepatitis C as risk factor for post-transplant end-stage renal disease. Patients with BMI over 35 had a 28% increased risk of post-LT end stage renal disease compared to those with lower BMI. Diagnosis of hepatitis C was associated with 31% higher risk of post-transplant end stage renal disease compared to non-hepatitis C diagnoses. The study also show
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Contact: Mary Masson
mfmasson@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

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