Navigation Links
Renal denervation improves blood pressure and arterial stiffness
Date:8/27/2012

Munich, Germany August 27 2012: Renal denervation improves blood pressure and arterial stiffness in patients with therapy resistant hypertension, according to research presented at ESC Congress 2012 by Mr Klaas Franzen from the University Hospital of Schleswig-Holstein. The findings suggest that renal denervation regenerates blood vessels and could reduce cardiovascular events.

Malignant arterial hypertension was historically treated with surgical thoracolumbar splanchnicectomy, a type of sympathectomy treatment that was introduced in 1938. "A significant reduction in blood pressure response was observed in at least half of the patients who underwent splanchnicectomy," said Mr Franzen. "But the treatment led to severe adverse events such as orthostatic hypotension, anhidrosis and intestinal disturbances. After the discovery of effective antihypertensive drugs, splanchnicectomy became neglected and disregarded over time."

In 2009 the concept of sympathectomy was reintroduced with intravasal catheter-based percutaneous renal sympathetic denervation (RDN) used in patients suffering from resistant arterial hypertension. Recent publications have shown that RDN significantly lowers systolic and diastolic peripheral brachial blood pressure by 32/12 mmHg after 6 months.

Mr Franzen said: "RDN with radiofrequency energy has several important advantages over surgical splanchnicectomy: it is a minimally invasive procedure without significant systematic side effects, it is well tolerated, and recovery times are short."

Arterial hypertension can irrevocably harm blood vessels in the short and long term, subsequently leading to increased aortic/arterial stiffness and arteriosclerosis. "Since central aortic pressures and arterial stiffness are much better predictors for future cardiovascular events than peripheral pressures we focused the present study on the effects of RDN on central hemodynamics and arterial stiffness," said Mr Franzen.

The researchers studied 21 patients with therapy resistant hypertension (61.9% men; mean age 64 years; 5.01.3 antihypertensive drugs) and 6 controls (83.3% men; mean age 57 years; 4.32.3 antihypertensive drugs). The inclusion criteria were: (i) use of >3 antihypertensive drugs, (ii) peripheral blood pressure at baseline ≥150 mmHg, and (iii) exclusion of secondary hypertension and anatomical abnormalities of the renal arteries.

RDN was performed with an RDN radiofrequency ablation catheter system (1). Central hemodynamics and arterial stiffness, i.e. pulse wave velocity (PWV), were recorded with an Arteriograph device (2). Measurements were performed at baseline, and 3 and 6 months after the intervention.

RDN led to an improvement in all parameters compared to baseline. Peripheral systolic blood pressure improved by 7.6% (145 mmHg versus 156 mmHg, p<0.05) after 3 months and by 5.4% (148 mmHg versus 156 mmHg, p<0.05) after 6 months. Central systolic blood pressure improved by 9.5% (147 mmHg versus 161 mmHg, p<0.01) after 3 months and by 6.6% (151 mmHg versus 161 mmHg, p<0.05) after 6 months. Most importantly, PWV improved significantly, both at 3 months (9.41.2 m/s versus 10.91.8 m/s, p<0.01) and 6 months (9.71.8 m/s versus 10.91.8 m/s, p<0.01). Univariate analysis of variance (f-test) showed that the improvement of PWV was, at least in part, blood pressure independent.

In controls no significant changes in blood pressure values or PWV were observed.

"Besides peripheral blood pressures, RDN improved central blood pressures and arterial stiffness, i.e. PWV," said Mr Franzen. "According to age adjusted reference values, the improvement of approximately 1m/s PWV observed in our study could be interpreted as a blood vessel rejuvenation of almost 10 years. This suggests that RDN might be a fountain of youth for blood vessels in patients with therapy resistant hypertension."

He added: "Further studies are needed to determine whether the benefits of RDN translate into a reduced risk of cardiovascular events."


'/>"/>

Contact: ESC Press Office
press@escardio.org
European Society of Cardiology
Source:Eurekalert

Related medicine news :

1. Newborn Screening May Miss Adrenal-Gland Disorder
2. Broken heart syndrome protects the heart from adrenaline overload
3. Renal denervation gives better outcomes than drugs in advanced heart failure
4. Renal denervation treats resistant hypertension in real world patient populations
5. Renal sympathetic denervation improves physical and mental health in resistant hypertension
6. Renal denervation achieves significant and sustained blood pressure reduction
7. Clinical insight improves treatment with new lung cancer drug
8. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
9. Exercise improves quality of life during breast cancer treatment
10. Early treatment improves outcomes in rare, often undiagnosed form of encephalitis
11. NYUCNs Dr. Laura Wagner: Study finds accreditation improves safety culture at nursing homes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... ... The SeniorCare Investor will host an important webinar— Seniors Housing M&A: The ... PM ET. A recording of the webinar will also be made available following its ... want to find out what really happened in the seniors housing and care merger ...
(Date:2/22/2017)... ... February 22, 2017 , ... Pet obesity in the U.S. ... dogs, according to the Association for Pet Obesity Prevention (APOP). During the ninth annual ... issues such as the benefits of corn and grains, value of raw and organic ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... military veterans who suffer from combat-related PTSD. , Established in 1977, our organization ... Vietnam-era, the challenges of military returning to civilian life were evident and served ...
(Date:2/22/2017)... ... February 22, 2017 , ... In today’s world, ... solutions on the market, it is easy to start feeling frustrated and confused. ... offers a complimentary security consultation. , Home Security Hardware Choices, There are innumerable ...
(Date:2/22/2017)... Wis (PRWEB) , ... February 22, 2017 , ... ... a category by itself - the Vector™ Series Multi-Cook Oven offers up to ... oven chamber, featuring exclusive Structured Air Technology™ for unmatched evenness in cooking. Alto-Shaam ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... On Tuesday, February 21, ... Average, and the S&P 500 edged higher at ... ended Tuesday,s trading session in bullish territories. Taking ... following Medical Instruments & Supplies equities this morning: ... Bard Inc. (NYSE: BCR), Glaukos Corporation (NYSE: GKOS), ...
(Date:2/22/2017)... 2017  Applied Silver, the maker of SilvaClean®, today announced ... advisory board. Ms. Barnes is the company,s third Clinical Advisor ... and healthcare experts Scott McNealy , Josh McQueen ... J. Tress Ritter , and Leopold Selker . ... than three decades of nationally recognized clinical, nursing, and infection ...
(Date:2/22/2017)... Feb. 22, 2017  Aytu BioScience, Inc. (OTCQX: AYTU), ... novel products in the field of urology, today announced ... to 42 account managers from 35 currently, a 20% ... The sales force expansion is being driven by the ... an indication of increasing acceptance of Natesto,s unique product ...
Breaking Medicine Technology: