Navigation Links
Renal denervation improves blood pressure and arterial stiffness
Date:8/27/2012

Munich, Germany August 27 2012: Renal denervation improves blood pressure and arterial stiffness in patients with therapy resistant hypertension, according to research presented at ESC Congress 2012 by Mr Klaas Franzen from the University Hospital of Schleswig-Holstein. The findings suggest that renal denervation regenerates blood vessels and could reduce cardiovascular events.

Malignant arterial hypertension was historically treated with surgical thoracolumbar splanchnicectomy, a type of sympathectomy treatment that was introduced in 1938. "A significant reduction in blood pressure response was observed in at least half of the patients who underwent splanchnicectomy," said Mr Franzen. "But the treatment led to severe adverse events such as orthostatic hypotension, anhidrosis and intestinal disturbances. After the discovery of effective antihypertensive drugs, splanchnicectomy became neglected and disregarded over time."

In 2009 the concept of sympathectomy was reintroduced with intravasal catheter-based percutaneous renal sympathetic denervation (RDN) used in patients suffering from resistant arterial hypertension. Recent publications have shown that RDN significantly lowers systolic and diastolic peripheral brachial blood pressure by 32/12 mmHg after 6 months.

Mr Franzen said: "RDN with radiofrequency energy has several important advantages over surgical splanchnicectomy: it is a minimally invasive procedure without significant systematic side effects, it is well tolerated, and recovery times are short."

Arterial hypertension can irrevocably harm blood vessels in the short and long term, subsequently leading to increased aortic/arterial stiffness and arteriosclerosis. "Since central aortic pressures and arterial stiffness are much better predictors for future cardiovascular events than peripheral pressures we focused the present study on the effects of RDN on central hemodynamics and arterial stiffness," said Mr Franzen.

The researchers studied 21 patients with therapy resistant hypertension (61.9% men; mean age 64 years; 5.01.3 antihypertensive drugs) and 6 controls (83.3% men; mean age 57 years; 4.32.3 antihypertensive drugs). The inclusion criteria were: (i) use of >3 antihypertensive drugs, (ii) peripheral blood pressure at baseline ≥150 mmHg, and (iii) exclusion of secondary hypertension and anatomical abnormalities of the renal arteries.

RDN was performed with an RDN radiofrequency ablation catheter system (1). Central hemodynamics and arterial stiffness, i.e. pulse wave velocity (PWV), were recorded with an Arteriograph device (2). Measurements were performed at baseline, and 3 and 6 months after the intervention.

RDN led to an improvement in all parameters compared to baseline. Peripheral systolic blood pressure improved by 7.6% (145 mmHg versus 156 mmHg, p<0.05) after 3 months and by 5.4% (148 mmHg versus 156 mmHg, p<0.05) after 6 months. Central systolic blood pressure improved by 9.5% (147 mmHg versus 161 mmHg, p<0.01) after 3 months and by 6.6% (151 mmHg versus 161 mmHg, p<0.05) after 6 months. Most importantly, PWV improved significantly, both at 3 months (9.41.2 m/s versus 10.91.8 m/s, p<0.01) and 6 months (9.71.8 m/s versus 10.91.8 m/s, p<0.01). Univariate analysis of variance (f-test) showed that the improvement of PWV was, at least in part, blood pressure independent.

In controls no significant changes in blood pressure values or PWV were observed.

"Besides peripheral blood pressures, RDN improved central blood pressures and arterial stiffness, i.e. PWV," said Mr Franzen. "According to age adjusted reference values, the improvement of approximately 1m/s PWV observed in our study could be interpreted as a blood vessel rejuvenation of almost 10 years. This suggests that RDN might be a fountain of youth for blood vessels in patients with therapy resistant hypertension."

He added: "Further studies are needed to determine whether the benefits of RDN translate into a reduced risk of cardiovascular events."


'/>"/>

Contact: ESC Press Office
press@escardio.org
European Society of Cardiology
Source:Eurekalert

Related medicine news :

1. Newborn Screening May Miss Adrenal-Gland Disorder
2. Broken heart syndrome protects the heart from adrenaline overload
3. Renal denervation gives better outcomes than drugs in advanced heart failure
4. Renal denervation treats resistant hypertension in real world patient populations
5. Renal sympathetic denervation improves physical and mental health in resistant hypertension
6. Renal denervation achieves significant and sustained blood pressure reduction
7. Clinical insight improves treatment with new lung cancer drug
8. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
9. Exercise improves quality of life during breast cancer treatment
10. Early treatment improves outcomes in rare, often undiagnosed form of encephalitis
11. NYUCNs Dr. Laura Wagner: Study finds accreditation improves safety culture at nursing homes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... January 23, 2017 , ... Zachary Cattell, ... serve as a healthcare industry expert at the 2017 Sector Summit hosted by ... Inside Indiana Business host Gerry Dick, will feature an employer and an association ...
(Date:1/23/2017)... ... 23, 2017 , ... Moisture measurement is a necessary process ... paramount to success. Selecting an inappropriate measurement method can cause costly errors, and ... same equipment. Rare or expensive substances are wasted and production may even be ...
(Date:1/23/2017)... ... January 23, 2017 , ... "ProRandom is a set of camera tools that allow ... looks in Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... layers of text with video footage. ProRandom works by using a virtual camera to ...
(Date:1/23/2017)... ... January 23, 2017 , ... The ... of Anesthesiologists® (ASA®), the Foundation for Anesthesia Education and Research (FAER), the ... and the Cigna Foundation, encourages proposals supporting high quality research using perioperative ...
(Date:1/23/2017)... ... January 23, 2017 , ... “The Inn at the Mill”: a story of love and ... quest to become happy and content. , “The Inn at the Mill” is the ... in Germany and Vermont and is now living in Berks County on Crow Hill. ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... Direct-to-consumer digital marketing ... and 65% increase in consumable sales, quarter-over-quarter ... DRIO ), a leader in digital health ... Dario™ Blood Glucose Monitoring System, an all-in-one diabetes meter, ... and minimally invasive smart diabetes management solution. ...
(Date:1/23/2017)... The American Pharmacists Association (APhA) is excited ... Medically Underserved Areas Enhancement Act (H.R. 592) ... was previously introduced in the 114 th session ... through pharmacists and their patient care services. ... (R-KY), G.K. Butterfield (D-NC), Tom ...
(Date:1/23/2017)... New York , January 23, 2017 ... Non-Invasive Prenatal Testing Market was valued at US$0.53 bn in ... expanding at a strong 17.50% CAGR between 2014 and 2022. The ... Global Industry Analysis, Size, Volume, Share, Growth, Trends and Forecast 2014 ... Non-invasive ...
Breaking Medicine Technology: