Navigation Links
'Renal Assist Device' reduces risk of death from acute kidney failure
Date:3/4/2008

For patients with acute kidney injury (AKI), an external device containing human kidney cells promotes recovery of the injured kidneys and significantly reduces the risk of death, according to a preliminary clinical study published in the May Journal of the American Society of Nephrology.

The experimental renal tubule assist device (RAD) appears safe and effective for desperately ill patients with AKI. "Deployment of the RAD was associated with remarkably better outcomes for these patientsspeeding recovery of kidney function and reducing risk of death by half," comments Dr. H. David Humes of University of Michigan, one of the study authors.

Patients with AKI have sudden loss of kidney function, resulting from a wide range of possible causes (such as blood loss or toxic injury). The goal of treatment is to replace lost kidney function through dialysis and related techniques until the kidneys have time to recover. However, even with treatment, the risk of death during an episode of AKI is 50 percent or higher.

In the new study, 40 of 58 patients with AKI were randomly assigned to treatment with the RAD, in addition to standard renal replacement therapy. The RAD is a conventional blood filter device lined with human renal tubule cells, grown from donor kidneys. "The cells are made available to carry out subtle metabolic and endocrine functions that the patient's failing kidneys can no longer perform, thereby staunching a cascading decline in the patient's health and allowing time for the patient's own organs to recover," Dr. Humes explains.

Outcomes were significantly better for AKI patients treated with the RAD. After one month, 33 percent of patients in the RAD group had died, compared to 61 percent of those treated with renal replacement therapy only. Patients who received the RAD were also more likely to be alive after six months. With adjustment for other factors, the risk of death was about 50 percent lower in the RAD group.

Patients in the RAD group also had a shorter time to return of kidney function. Overall, kidney function recovered in 53 percent of patients with RAD, compared to 28 percent without RAD. In both groups, about 20 percent of patients survived but never recovered kidney function, requiring chronic dialysis.

Although the initial results are encouraging, the benefits of RAD treatment need to be confirmed in larger studies. In addition, the researchers need to study the effects of changes in the design of the RAD, which are needed to accommodate mass production.

In addition to improving the outcomes of AKI, the results may point the way toward entirely new classes of cell-based and tissue-engineered therapies. "The ability to harness vital processes of cells, to target their living molecular machinery on restoring critical substances which have become disordered by disease, has vast implications for the future of medicine," says Dr. Humes. "Particularly, we are encouraged that we can develop a related device to treat chronic renal failurea wearable kidney that performs natural functions unachievable through man-made technology alone."


'/>"/>

Contact: Shari Leventhal
sleventhal@asn-online.org
202-416-0658
American Society of Nephrology
Source:Eurekalert

Related medicine news :

1. Statement by Robert D. Foreman, President of The Kidney Care Council, Regarding the HHS Report to Congress A Design for a Bundled End Stage Renal Disease Prospective Payment System
2. PLC Systems Files IDE Supplement to Begin Pivotal Study of RenalGuard(TM) and Provides Update on Planned Development Timeline
3. PLC Systems Receives CE Mark Approval for RenalGuard(TM)
4. UT Southwestern: Patients with mild Cushing syndrome may benefit from adrenalectomy
5. Follow-up imaging of benign-appearing incidental adrenal masses is unnecessary
6. Renal Solutions, Inc. Announces Acquisition by Fresenius Medical Care
7. Serum carcinoembryonic antigen level can reflect adrenal adenoma
8. FDA Approves MIRCERA(R): First Renal Anemia Treatment with Monthly Maintenance Dosing
9. PLC Medical Systems to Display RenalGuard(TM) During Renal Week 2007
10. Nephrologists summarize new renal research during public policy news briefing at Renal Week
11. Renal Solutions, Inc. Announces FDA 510(k) Clearance of New Design of the Allient(R) Sorbent Hemodialysis System for Chronic and Acute Hemodialysis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has written a new ... the Bible about helping to stop cancer. Yisrayl says there are too many suffering and ... health and science industries will pay close attention and take action. The Pastor says that ...
(Date:5/6/2016)... ... ... “ Crossing Over: Affirmations of Faith in the Midst of the Dying ” ... vigil to glimpse into the supernatural as their lives ended. With her debut book, ... gain insight into providing care to terminal patients. , “I was inspired to ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... (LAIs), today announced a development collaboration with the Australian critical medicine company, ... disorders such as schizophrenia. , LAI medicines can offer improved therapeutic benefits over ...
(Date:5/5/2016)... ... , ... TLC Laser Eye Centers announced today that it has acquired Gordon ... be called “Gordon Schanzlin New Vision Institute, a TLC Laser Eye Center.” , ... ensure that patients continue to receive the highest quality of care. In addition, all ...
(Date:5/5/2016)... ... 2016 , ... LELO has discovered many people are insecure about ... via email, social media and on the Volonté blog seeking advice about how to ... ‘normal’ or ‘correct’?” , While some methods are more common than others, there is ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... , May 6, 2016 ... of liver disorders along with rise in obesity ... drugs in the coming few years. The NASH ... last five years on account of rising number ... is a large, un-tapped market with no FDA ...
(Date:5/5/2016)... -- , First quarter 2016 adjusted diluted ... million , First quarter reported diluted (GAAP) ... , Company revises 2016 financial guidance; now expects 2016 ... 2016 adjusted diluted non-GAAP earnings per share to range from ... regarding Generics business and manufacturing facility restructuring , ...
(Date:5/5/2016)... May 5, 2016 Research and Markets has ... in Top 5 EU Markets"  report to their offering.  ,     ... provides information on the current Positron Emission Tomography (PET) scanner ... (T5 EU), which includes France , ... Spain and the United Kingdom ...
Breaking Medicine Technology: