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Removing 2mm around breast cancer tumors prevents residual disease in 98 percent of patients
Date:10/18/2010

an 2mm.

However, when it came to the women who had received surgery for non-invasive cancer, residual disease was higher and the pattern was less than clear. Incidence ranged from 0% at more than 5mm to 57% when the margin was between 0.1 to 0.9mm, but 44% where no margin was involved.

The research team also looked at the characteristics of the 202 women who had had a close free margin of less than 2mm and the 101 women who had had a clear free margin of 2mm or more.

They found that women with a close margin of less than 2mm were more likely to be associated with large grade three tumours than the clear margin group (46% versus 42%) and with lymphovascular invasion (52% versus 40%) and nodal involvement (48% versus 33%).

In addition to the women who underwent wider re-excision to determine any residual disease, 13% went on to have a mastectomy and the remaining 56% did not have further surgery.

"Our research found that the overall probability of finding residual disease was 2.4% if a woman had surgery where the free margin was 2mm or more from the invasive cancer. But the same pattern was not observed when the woman had surgery for non-invasive cancer, where the incidence of residual disease was higher.

"Based on these results, we feel confident that a free margin of 2mm from the area of invasive cancer is adequate to minimise residual disease, but the equivalent free margin for non-invasive cancer remains unclear.

"Eliminating the possibility of residual disease during breast conserving surgery is very important as nearly 50 per cent of patients with local recurrence go on to develop secondary breast cancer, which is a progressive incurable disease."


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Contact: Annette Whibley
wizard.media@virgin.net
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

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