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Removing 2mm around breast cancer tumors prevents residual disease in 98 percent of patients
Date:10/18/2010

Removing an extra two millimetres around an area of invasive breast cancer is sufficient to minimise any residual disease in 98 per cent of patients, according to research published in the November issue of IJCP, the International Journal of Clinical Practice.

Surgeons from the Department of Breast Surgery at Good Hope Hospital, Sutton Coldfield, UK, studied 303 women who had undergone breast conserving surgery at the hospital between 2002 and 2008.

"Breast conserving surgery followed by radiotherapy is a well-established alternative to breast removal and studies have demonstrated similar survival rates in patients undergoing these procedures" explains lead author Dr Stephen Ward.

"However patients undergoing breast conserving surgery are more likely to have recurrent cancer and the amount of tissue removed around the tumour, known as the free margin, remains controversial.

"A survey of 200 UK breast surgeons published in 2007 revealed wide variations in what they considered to be an adequate margin, with 24% wanting a clear margin of 1mm and 65% wanting a margin of 2mm or more. This study highlighted differences in practice across different units and the need for evidence-based guidelines."

The Good Hope team carried out further excision specimens on 31% of the women who had received breast conserving surgery to check for residual disease, obtaining 139 samples from 93 patients. Of these, 52 samples were from patients who had received surgery for non-invasive cancer, where the cancer is confined to the milk ducts or lobules, and 87 were from patients who had had invasive cancer, where the cancer had spread to the surrounding breast tissue.

They found that in the women who had received surgery for invasive cancer, the amount of residual disease, defined as the presence of invasive or non-invasive cancer, reduced as the free margin increased - from 35.3% with no margin to 2.4% with a margin of more th
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Contact: Annette Whibley
wizard.media@virgin.net
Wiley-Blackwell
Source:Eurekalert

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