Navigation Links
'Relocation' plan of metastatic cancer cells uncovered by Stanford researchers
Date:1/5/2009

STANFORD, Calif. Few things are as tiresome as house hunting and moving. Unfortunately, metastatic cancer cells have the relocation process down pat. Tripping nimbly from one abode to another, these migrating cancer cells often prove far more deadly than the original tumor. Although little has been known about how these rogue cells choose where to put down roots, researchers at the Stanford University School of Medicine have now learned just how nefarious they are.

"Metastasis is not a passive process," said cancer biologist Amato Giaccia, PhD. "Cells don't just break off the primary tumor and lodge someplace else. Instead the cells actually secrete substances to precondition target tissue and make it more amenable to subsequent invasion."

In other words, the cells plan ahead by first sending molecular emissaries to orchestrate a breach in the body's natural defenses. Blocking this cascade of events in mice hobbled the cells' migration and prevented the metastatic cancer that developed in control animals. The researchers are hopeful that a similar tactic will be equally successful in humans.

Giaccia, the Jack, Lulu and Sam Willson Professor and professor of radiation oncology at Stanford, is the senior author of the research, which will be published in the Jan. 6 issue of Cancer Cell. Giaccia is also a member of the Stanford Cancer Center.

Scientists have known for some time that certain primary cancers metastasize preferentially to other organs breast cancer often spreads to the lungs, for example. This is in part due to the patterns of blood flow in the body. They also knew that such future colonization sites, called pre-metastatic niches, harbor large numbers of cells derived from the bone marrow that somehow facilitate the cancer cells' entry. What they didn't know is how the bone-marrow-derived cells were summoned, and what, if any, role the primary tumor cells played in site selection.

Giaccia and
'/>"/>

Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Volcano Corporation Announces the Relocation of Corporate Headquarters to San Diego
2. China Biologic Products Announces Approval for the Relocation of Fang Cheng Plasma Collection Station and for the Procurement of Excess Clinical Plasma
3. Eclipsys Announces Relocation of Corporate Headquarters to Atlanta, GA
4. Acupuncturists Relocation Tightens Relationship With Fertility Clinic
5. Combination of TYKERB(R) (lapatinib) Plus Letrozole Demonstrated Significant Improvement in Delaying Disease Progression for HER2+/ErbB2+ Post-Menopausal Metastatic Breast Cancer
6. Estrogen pills can benefit women with metastatic breast cancer
7. HER2 levels may aid in treatment selection for metastatic breast cancer
8. Debiopharm Announces U.S. NDA Filing of Trelstar(R) 6-Month Formulation for Locally Advanced or Metastatic Prostate Cancer
9. Grupo IMO Hosts Symposium on Use of TomoTherapy for Stereotactic Radiosurgery and Stereotactic Body Radiation Procedures : Experts Detail HiArt Platform Advantages for Treatment of Brain, Lung, Pancreatic and Metastatic Cancers
10. Blood vessel inhibitor shows promise against metastatic thyroid cancer
11. Discovery of gene mechanism could bring about new ways to treat metastatic cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... The U.S. Food & Drug ... Entertainment Industries Council (EIC) have teamed with entertainment ... Story on a first-of-its-kind Decorative Contact Lens ... illegal and unsafe lens use to the forefront. ... tens-of-thousands, is now releasing its second production which ...
(Date:7/24/2014)... -- Some babies are at risk for autism because they ... find new ways to detect Autism Spectrum Disorder (ASD) earlier ... with others and how they relate to the possibility and ... to understand the connection between early joint attention before one ... form of communication that develops toward the end of the ...
(Date:7/24/2014)... Skirt Sports, the innovative women’s running apparel brand is proud ... from an idea by professional triathlete Nicole DeBoom during a ... this one innovative piece of running gear revolutionized the fitness ... in Wisconsin to incorporate Skirt Sports, the first company to ... I drew the first sketch of a running skirt on ...
(Date:7/24/2014)... July 24, 2014 The report, “Feed ... Synthetic), by Livestock (Swine, Poultry, Cattle, Pets, Aquaculture, and ... and segments the feed palatability enhancers & modifiers market ... in terms of value, of types of feed flavors, ... tables and 17 figures spread through 275 pages and ...
(Date:7/24/2014)... County high school students are smoking tobacco products at ... to new data from the Prevention Research Center for ... 2013, more than 22 percent, or one in five ... within the prior 30 days. , Equally surprising is ... hookahs, or water pipes, more than cigarettes matching ...
Breaking Medicine News(10 mins):Health News:Optometric Professionals Team with Hollywood for Second Installment of Video Campaign 2Health News:Optometric Professionals Team with Hollywood for Second Installment of Video Campaign 3Health News:Optometric Professionals Team with Hollywood for Second Installment of Video Campaign 4Health News:Early warning sign for babies at risk of autism 2Health News:Skirt Sports Celebrates Its 10-Year Anniversary and 10 Years of the Running Skirt With a Virtual Community Building Run 2Health News:Skirt Sports Celebrates Its 10-Year Anniversary and 10 Years of the Running Skirt With a Virtual Community Building Run 3Health News:Feed Palatability Enhancers & Modifiers Market Worth $3172.6 Million by 2019 - Report by MarketsandMarkets 2Health News:Feed Palatability Enhancers & Modifiers Market Worth $3172.6 Million by 2019 - Report by MarketsandMarkets 3Health News:Feed Palatability Enhancers & Modifiers Market Worth $3172.6 Million by 2019 - Report by MarketsandMarkets 4Health News:Cuyahoga County high school students smoking at the same rate as adults 2Health News:Cuyahoga County high school students smoking at the same rate as adults 3Health News:Cuyahoga County high school students smoking at the same rate as adults 4
... PALO ALTO, Calif., Feb. 1 Lifespring Health,sponsors the ... Run.,This is an important charity event benefiting the Hemophilia ... Disabilities and,the Koret Family House., Set to take ... Marathon,Championship certified 13.1 mile course is ranked as one ...
... non-REM sleep (45 minutes) obtained during a daytime nap clearly ... published in the February 1 issue of the journal SLEEP. ... the Center for Sleep and Cognition and the department of ... males, 22 females) with an average age of 23.3 years. ...
... North Carolina researchers have found that women with irritable bowel ... have a heightened brain response to pain that makes them ... affects 10 to 15 percent of the population and causes ... , Researchers used brain imaging to show that patients ...
... Business Leaders Learn How Their Employee Health Benefit ... Business owners and human,resource executives grappling with ... and cost effective found out how their plans,compare ... Embassy Suites,Parsippany. Scott Rappoport, a 25-year veteran of ...
... Gastric Band Surgery Performed Each Month in ... LONDON, February 1 Today saw the launch ... information and support to people considering obesity surgery. To,coincide ... new survey reveal,widespread confusion over the causes of obesity ...
... getting preventive treatments , , THURSDAY, Jan. 31 (HealthDay ... hospitals worldwide risk developing dangerous blood clots known ... that could prevent the condition, a large international ... recognized to be one of the most common ...
Cached Medicine News:Health News:Journal Sleep: Study concludes a daytime nap can benefit a person's memory performance 2Health News:Key to Attracting and Retaining Quality Employees: Benefits 2Health News:Key to Attracting and Retaining Quality Employees: Benefits 3Health News:Lose Weight Gain Life: New Website to Help People Seeking Information on Obesity Surgery 2Health News:Lose Weight Gain Life: New Website to Help People Seeking Information on Obesity Surgery 3Health News:Hospital Patients' Blood Clot Risk High 2Health News:Hospital Patients' Blood Clot Risk High 3
(Date:7/24/2014)... -- Delivery of the Report will take 2-3 ... Photo - http://photos.prnewswire.com/prnh/20140723/129707 ... on Global and Chinese Hemodialysis Machine industry. The ... Machine including its classification, application and manufacturing technology. ... manufacturers of Hemodialysis Machine listing their product specification, ...
(Date:7/24/2014)... 24, 2014 Cancer patients in the west of ... cancer treatment closer to home when a new radiotherapy center ... Medical Systems (NYSE: VAR ) has been selected ... in June for four TrueBeam™ medical linear accelerators. ... and efficient radiotherapy and radiosurgery treatments, will replace older treatment ...
(Date:7/24/2014)...  Blueprint Medicines (Blueprint), a leader in discovering highly ... announced the appointment of Jeffrey Albers as ... Algeta ASA, where he served on the executive management ... Bayer. Mr. Albers succeeds Alexis Borisy , co-founder ... Rock Ventures, who will remain an active member of ...
Breaking Medicine Technology:Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 2Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 3Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 4Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 5Varian Medical Systems Selected to Equip First Satellite Radiotherapy Center in Scotland 2Varian Medical Systems Selected to Equip First Satellite Radiotherapy Center in Scotland 3Blueprint Medicines Appoints Jeffrey Albers as Chief Executive Officer 2
... Nov. 14, 2011 Tengion, Inc. (Nasdaq: ... of a restructuring plan, and reported its financial results ... restructuring plan is designed to fund the Company,s lead ... the Company,s anticipated cash utilization.  As a result of ...
... Texas, Nov. 14, 2011 Novation commends the IMS ... raising awareness of the drug shortage crisis facing America,s ... Look at Products, Suppliers and Volume Volatility."   ... 2011 Executive Order, is helping bring much-needed attention to ...
Cached Medicine Technology:Tengion Provides Business Update and Reports Third Quarter 2011 Financial Results 2Tengion Provides Business Update and Reports Third Quarter 2011 Financial Results 3Tengion Provides Business Update and Reports Third Quarter 2011 Financial Results 4Tengion Provides Business Update and Reports Third Quarter 2011 Financial Results 5Tengion Provides Business Update and Reports Third Quarter 2011 Financial Results 6Tengion Provides Business Update and Reports Third Quarter 2011 Financial Results 7Tengion Provides Business Update and Reports Third Quarter 2011 Financial Results 8Tengion Provides Business Update and Reports Third Quarter 2011 Financial Results 9Tengion Provides Business Update and Reports Third Quarter 2011 Financial Results 10Novation Applauds the IMS Institute for Healthcare Informatics for Calling Attention to the Drug Shortage Crisis Facing American Hospitals 2Novation Applauds the IMS Institute for Healthcare Informatics for Calling Attention to the Drug Shortage Crisis Facing American Hospitals 3
The Surgiflex WAVE XP couples the state-of-the-art Surgiflex WAVE Probe with the convenience of a truly portable battery-powered pump....
Stryker Endoscopy has combined a standardized pressurizing system with an advanced hand piece design that is lightweight and compact in order to streamline laparoscopic procedures....
... specifically to disintegrate renal and ... state-of-the-art technology in a compact ... efficient and affordable lithotripsy system. ... level of clinical results for ...
...
Medicine Products: