Navigation Links
Reliable biomarkers needed for early detection of liver cancer
Date:2/25/2010

While biomarkers are needed to complement ultrasound in the early detection of hepatocellular carcinoma (HCC; liver cancer), neither des-gamma-carboxy prothrombin (DCP) nor the most widely used biomarker, alpha fetoprotein (AFP), is optimal, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

"Most surprising was the finding that patient demographics influenced both des-gamma-carboxy prothrombin and alpha fetoprotein values, but in opposite directions," said Anna S. Lok, MD, AGAF, of the University of Michigan Medical Center and lead author of the study. "This observation merits further investigation, as it might impact the accuracy of these biomarkers in the detection of liver cancer."

The study was conducted in 10 centers in the U.S. and funded by the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health.

Among 1,031 patients randomized in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis Trial, a nested case-control study of 39 HCC cases (24 early stage) and 77 matched controls was conducted to compare the performance of AFP and DCP. Testing was performed on serial serum samples collected during a 12-month period prior to the time of HCC diagnosis. Study results indicated that:

  • The sensitivity and specificity of DCP at month 0 (at the time of HCC diagnosis) was 74 percent and 86 percent at a cutoff of 40 mAU/mL, and 43 percent and 100 percent at a cutoff of 150 mAU/mL.
  • The sensitivity and specificity of AFP at month 0 was 61 percent and 81 percent at a cutoff of 20 ng/mL, and 22 percent and 100 percent at a cutoff of 200 ng/mL.
  • At month -12 (12 months before the diagnosis of HCC), the sensitivity and specificity at the low cutoff was 43 percent and 94 percent for DCP, and 47 percent and 75 percent for AFP.
  • Combining both markers increased the sensi
    '/>"/>

Contact: Alissa J. Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Atrion Networking Corporation Selects Ruckus Wireless for Reliable as Wire Enterprise Wi-Fi Service
2. NetMotion Wireless Publishes New Healthcare White Paper: Secure, Reliable Connections for Better Patient Care
3. Studies Find PSA Screening Unreliable
4. FaxSIPit and FaxBack Announce Partnership To Bring Reliable VoIP Fax to Service Providers
5. Kansas City Patients Rate Their Doctors in Most Reliable Survey of Its Kind
6. Headache Sufferers Turn to Neurologychannel for Reliable Information about New Headache Treatments
7. Medgateway.com Provides a Gateway to Reliable Health and Medical Information on the Internet.
8. Study finds that using wakefulness tests to detect daytime sleepiness in drivers may be unreliable
9. That gut feeling may actually reflect a reliable memory
10. www.greatplacesinc.com Isthe Leading Internet Resourcefor Current, Relevant, Reliable Advice,Counseling the 76 MillionBaby Boomers Who Are Increasingly Responsible for Their Aging Parents' Care
11. Risk assessment tool not reliable predictor for some women at high risk of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... 2014 A Xarelto lawsuit webpage ... to provide consumers with the most current information regarding ... the blood-thinning medication, as well as the growing ... around the country. The law firm is now offering ... from life-threatening internal bleeding and related complications while using ...
(Date:7/13/2014)... July 13, 2014 According to The ... is a comprehensive program that teaches people how to ... neuropathy without medications. This program also provides people ... of peripheral neuropathy , including numbness, prickling, burning, and ... review that this home treatment program can help people ...
(Date:7/12/2014)... Recently, iFitDress.com, one of the world’s leading ... red evening gowns . What’s more, all these hot outfits ... The company’s senior spokesman states, “We are proud to announce ... is an enjoyable shopping experience. In addition to the big ... low prices do not always mean bad quality. All the ...
(Date:7/12/2014)... The report, "Phthalic Anhydride and Derivatives ... Application & Geography – Trends & Forecast to 2018," ... forecasting of market volume and value. The report also ... The market of phthalic anhydride is projected to grow ... million by 2018, with a CAGR of 5.24% from ...
(Date:7/12/2014)... The Security Analytics market is estimated to grow from ... at an expected CAGR of 9.7% for the period ... increasing number of security breaches, continued line of sophisticated ... organizations are enormous. Vendors in the security analytics market ... develop better and more secure systems. , There has ...
Breaking Medicine News(10 mins):Health News:Xeralto Lawsuit Page Launched By Wright & Schulte LLC To Provide Information On Potential For Xarelto Bleeding Side Effects, Growing Litigation 2Health News:Xeralto Lawsuit Page Launched By Wright & Schulte LLC To Provide Information On Potential For Xarelto Bleeding Side Effects, Growing Litigation 3Health News:Xeralto Lawsuit Page Launched By Wright & Schulte LLC To Provide Information On Potential For Xarelto Bleeding Side Effects, Growing Litigation 4Health News:The Peripheral Neuropathy Program Review Exposes Randall Labrum's Peripheral Neuropathy Treatment Program – Vkool.com 2Health News:The Peripheral Neuropathy Program Review Exposes Randall Labrum's Peripheral Neuropathy Treatment Program – Vkool.com 3Health News:Discounted Red Evening Gown Announced by iFitDress.com 2Health News:Phthalic Anhydride Market Projected to Reach $8.42 Billion by 2018 – Report by MarketsandMarkets 2Health News:Phthalic Anhydride Market Projected to Reach $8.42 Billion by 2018 – Report by MarketsandMarkets 3Health News:Phthalic Anhydride Market Projected to Reach $8.42 Billion by 2018 – Report by MarketsandMarkets 4Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 4
... ,better for you, options; portion-controlled treats remain popular this ... ... Oct. 1 For the 93 percent of kids who will,trick-or-treat ... ever before, including more health-minded product options,available alongside the classic treats, ...
... ZURICH, Switzerland, October 1 , - Share Exchange Offer to ... & Johnson - ISIN: US4781601046 - Symbol: JNJ, The K&N ... every 1 Johnson & Johnson share a change into 1 share ... The offer period starts on 13th October 2008 and ends ...
... of almost 1,500 kidney cancer patients treated at Memorial ... as much kidney tissue as possible may improve overall ... at the time their cancer is diagnosed. The finding ... function appear to be increasing. , "In patients who ...
... is a fact that,Multi-Drug Resistant organisms are on ... medicines. According to the World Health Organization,(WHO) these ... and mortality rates, which has led to a ... safe, natural and,complementary solutions to this growing problem., ...
... says physicians have unique opportunity to help parents and ... ... Washington, DC (Vocus) October 1, 2008 ... their families understand the http://www.childrensnational.org/?utm_source=pressrelease&utm_medium=9_30&utm_campaign=driving_safety [importance of responsible driving], ...
... on the horizon, dentists, ,as well as all other medical practitioners, ... Flasch, of Flasch Business Expansion. An award winning consultant with over ... expand their practices using precise business strategies. , ... ...
Cached Medicine News:Health News:Latest Trick-or-Treats Give You Something Good to Eat 2Health News:Latest Trick-or-Treats Give You Something Good to Eat 3Health News:Latest Trick-or-Treats Give You Something Good to Eat 4Health News:Research suggests doctors should consider kidney-sparing surgery 2Health News:Research suggests doctors should consider kidney-sparing surgery 3Health News:Argentyn 23(R) Homeopathic First Aid Gel - Another World's First by Natural-Immunogenics Corp. for Healthcare Professionals 2Health News:Healthcare Providers Can Help Reduce Teen Driving Deaths 2Health News:Healthcare Providers Can Help Reduce Teen Driving Deaths 3Health News:Medical Marketing Expert Offers Dentists Tips for Thriving Down Economy After the Wall Street Dilemma 2Health News:Medical Marketing Expert Offers Dentists Tips for Thriving Down Economy After the Wall Street Dilemma 3
(Date:7/11/2014)... 11, 2014 Patient engagement has become ... organizations are turning to an assortment of marketing ... part of this evolving approach to patient engagement, ... and engage patients throughout their experiences with a ... By mapping the patient journey and employing a ...
(Date:7/11/2014)... , July 11, 2014 Research and ... "Global and Chinese Medical X-ray Film Industry Report 2014" ... http://photos.prnewswire.com/prnh/20130307/600769 Global And Chinese Medical ... in-depth study on the current state of the Global ... Chinese situation. The report provides a basic overview ...
(Date:7/11/2014)... 2014  Kindred Hospital Houston Northwest, with Wound ... of its new outpatient wound healing center.  The ... with chronic, hard to heal wounds. Chronic wounds ... amputation, lower leg wounds related to blood flow ... traumatic injury wounds which are complex and demonstrate ...
Breaking Medicine Technology:New Study Uses Six-Step Patient Journey as Framework for Consumer-Focused Marketing Opportunities 2Global and Chinese Medical X-ray Film Industry Report 2014 2Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2
... Mass. , Feb. 4 Recognizing that corporate ... they contain, Northern Light ( www.northernlight.com ) today announced that ... excess of $2 billion can be searched, analyzed ... been steadily increasing the number of market research sources integrated ...
... N.C. , Feb. 4 Gorbec Pharmaceutical ... prescription pharmaceutical products, is opening a GMP-compliant analytical laboratory ... expand Gorbec,s current services for analytical method development and ... its U.S. customer base as well as develop a ...
Cached Medicine Technology:Northern Light Surpasses $2 Billion Worth of Research Content Integrated Into SinglePoint Strategic Research Portals 2Northern Light Surpasses $2 Billion Worth of Research Content Integrated Into SinglePoint Strategic Research Portals 3Gorbec Pharmaceutical Services, Inc. Announces the Launch of Its GMP Analytical Laboratory in China 2
With MediLive MindStream you can make, cut and edit digital videos, add commentaries and notes, and save them. MediLive MindStream - intuitive user interface and high-resolution monitor all in one....
... The VISUPAC system and the FF 450plus ... a unique level of accuracy and security ... or aftermarket configuration. Without this level of ... be assured.,Matching the VISUPAC system pixel for ...
... Monitor is the smartest, toughest and most ... an on-board artificial intelligence algorithm, DiogenesTM, the ... arrhythmias while on the patient. The Decipher ... all the rigorous tests required to monitor ...
... The Epicardia 4000 is a hospital-grade ... Epicardia software, Diogenes Arrhythmia and ST analysis ... supporting hardware and software. Facilities with an ... over running reports, customizing them to suit ...
Medicine Products: