Navigation Links
Rejected drug may protect against toxic substance common to Alzheimer's and Parkinson's diseases
Date:8/13/2012

umab trial has failed might only help patients if begun before the brain pathology begins to build up."

In the new study, the researchers administered the drug to three different systems: yeast, mice and mammal cells all showing build-up of alpha-synuclein, a protein known to cause neurodegeneration. In all three systems, they determined that latrepiridine activated autophagy, the so-called "self-eating" process of cells that protects the brain from neurodegeneration, which targeted synuclein and protected against its toxicity. In mice, the drug reduced the amount of synuclein accumulated in the brain through autophagy.

John Steele, PhD, a Mount Sinai neuroscience graduate student, devoted his PhD thesis to these studies. Lenard Lachenmayer, MD, a postdoctoral fellow working under the supervision of Zhenyu Yue, PhD, Associate Professor of Neurology at Mount Sinai, shares first authorship of the new paper with Steele and with Shulin Ju, PhD, a postdoctoral fellow at Brandeis University working under the direction of Greg Petsko, PhD, and Dagmar Ringe, PhD, both professors of biochemistry, chemistry and neuroscience at Brandeis.

This study is the second of two published by Dr. Gandy's team in Molecular Psychiatry. The first, published July 31, 2012, determined that latrepiridine stopped the toxicity of amyloid-beta protein accumulation in mice present with Alzheimer's disease by inducing autophagy. In that study, they randomly administered either latrepirdine or placebo to mice engineered to have the early stages of Alzheimer's disease and found that, through autophagy, the drug improved memory.

Dr. Petsko, an expert in protein structure who is now Professor of Neurology and Neuroscience at Weill Cornell Medical College, noted that, surprisingly, latrepirdine protects yeast cells from the toxicity of alpha-synuclein while leaving the cells vulnerable to killing by either the Huntington's disease protein or by either of the
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Rejected Alzheimers drug shows new potential
2. Gay Adults Rejected by Parents Have Worse Health, Study Finds
3. New Vaccine May Offer Protection From Deadly Nipah Virus
4. Protein that boosts longevity may protect against diabetes
5. Can herbal products provide sun protection?
6. NIH team describes protective role of skin microbiota
7. Researchers developing bioadhesive gel to protect women from HIV and HSV infections
8. Aspirin protects against Barretts esophagus
9. Vitamin D may protect against lung function impairment and decline in smokers
10. High Blood Pressure May Protect Some Frail Elderly: Study
11. Protecting the hearts of those waiting for kidney and liver transplants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... (PRWEB) September 30, 2014 For most ... the apple orchard, pumpkin patch or annual festival. For ... fast-spreading viruses – like the respiratory infection Enterovirus D68. ... most children, a small percentage – especially children with ... Increased concern about the Enterovirus is prompting hospitals across ...
(Date:9/30/2014)... Columbus, Ohio (PRWEB) September 30, 2014 ... and new viral strains emerging every day, it’s ... disinfecting system. The EnviroShield system is an ... and allows applications to surface normally missed with ... a spray nozzle that adds an electrostatic negative ...
(Date:9/30/2014)... A group of Americans is headed to ... that, left unchecked, could create a catastrophic, global pandemic. No, ... Africa. John Rogers, the Executive Director the Eugene Bell Foundation ... a disease most think mankind conquered long ago: tuberculosis. , ... is on the comeback in several countries - what’s especially ...
(Date:9/30/2014)... Two revolutionary procedures now being utilized by ... disease a far less painful and far more effective ... ever felt electric shock waves surge through your teeth as ... it’s possible you already know the impact of receding gums,” ... dentist in West Palm Beach, and a Fellow in the ...
(Date:9/30/2014)... TUESDAY, Sept. 30, 2014 (HealthDay News) -- Medicare should ... at high risk for the disease, a coalition of ... The coalition, which includes the Lung Cancer Alliance, the ... the American Cancer Society and the American Society of ... Monday to the U.S. Centers for Medicare & Medicaid ...
Breaking Medicine News(10 mins):Health News:As Hospitals Combat Enterovirus Outbreaks, Patients and Families Turn to “Virtual Visits” with CaringBridge 2Health News:Columbus Janitorial Company Announces New Disinfecting System for your workplace 2Health News:US Delegation Heads to North Korea to Combat Tuberculosis Epidemic 2Health News:Florida Dentist Battles Gum Disease With Latest Techniques 2Health News:Florida Dentist Battles Gum Disease With Latest Techniques 3Health News:Groups Call for Medicare Coverage of Lung Cancer Screening 2
... By Alan Mozes HealthDay Reporter , THURSDAY, March ... a common facet of dating for America,s adolescents, a new ... graders found that more than 37 percent of 11- to ... psychological violence, and almost one in six said they had ...
... (HealthDay News) -- Although eight states boosted their sales taxes ... in the number of such increases by states compared to ... Control and Prevention shows. One thing that smoking prevention ... as cigarette prices go up, the CDC said. ...
... common kidney cancer subtype, face a low risk of tumour ... findings of a multi-centre study of nearly 600 patients published ... . "Because papillary renal cell carcinoma ... the small number of patients enrolled in individual studies makes ...
... , WEDNESDAY, March 28 (HealthDay News) -- Tourists over age 65 ... die from the disease than those ages 18 to 35, a ... from more than 25,000 U.K. patients also found that the malaria ... West Africa. The risk of dying from malaria, an infection ...
... As part of an isolated indigenous group in central ... fishing, and clearing land by hand to grow crops. Their ... day might imply they have higher than average male testosterone ... of Washington have found, however, that the baseline testosterone level ...
... the World Health Organization (WHO) estimates that 20.1 million ... 1 and 2 across 9 world regions in 2005. ... Hepatology , a journal published by Wiley-Blackwell on ... Liver Diseases, there were 3.4 million symptomatic cases, 70,000 ...
Cached Medicine News:Health News:Dating Violence Common by 7th Grade: Survey 2Health News:Dating Violence Common by 7th Grade: Survey 3Health News:States' Efforts to Boost Cigarette Taxes Slows: CDC 2Health News:Kidney cancer subtype study finds low recurrence and cancer death rates 2Health News:Older Travelers at Much Higher Risk of Dying From Malaria 2Health News:Low testosterone level in Amazonian tribe responds to competition 2Health News:Over 20 million individuals infected with hepatitis E in Asia and Africa 2
(Date:9/30/2014)... 2014  Tasly Pharmaceuticals, Inc., the world,s leader ... today the launch of Deepure. Deepure ... men and women concerned with supporting their overall ... age while helping keep their health care cost ... herb-based formulas, namely, ProHeart PLUS, ImmunoPower PLUS, and ...
(Date:9/30/2014)... Arbor Pharmaceuticals, LLC. - Product Pipeline ... Direct,s, ,Arbor Pharmaceuticals, LLC. - Product Pipeline Review ... Pharmaceuticals, LLC.,s pharmaceutical research and development focus. ... therapeutic developmental pipeline of Arbor Pharmaceuticals, LLC.,s, complete ... by drug target, mechanism of action (MoA), route ...
(Date:9/30/2014)... Mass. , Sept. 30, 2014  Decision Resources Group finds ... Australia , China , ... Korea—will expand at a strong rate through 2023. Dental implant procedure ... and as patient awareness rises. Other key findings from ... dental implant market: , Dental implant penetration: ...
Breaking Medicine Technology:Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 3Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 2Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 3
... Comfort Pick one of our pipettors up ... trigger and ejector positionsright where they should beeven ... ergonomically designed to help avoid repetitive stress injuries ... In The Palm Of Your Hand Start ...
... Pick one of our pipettors up and ... and ejector positionsright where they should beeven if ... designed to help avoid repetitive stress injuries caused ... The Palm Of Your Hand Start dispensing ...
... total ergonomic solution and best value in ... touch action and ultra lightweight design reduce ... ejection with long, lever tip ejector , ... Accepts universal tips or for greater performance ...
... The Finnpipette BioControl multichannel ... features as the single ... handle fits allseven multichannel ... tip cone modules. Both ...
Medicine Products: