Navigation Links
Rejected drug may protect against toxic substance common to Alzheimer's and Parkinson's diseases
Date:8/13/2012

The second of two studies on latrepirdine, recently published in Molecular Psychiatry, demonstrates new potential for the compound in the treatment of Alzheimer's disease, Parkinson's disease, sleep disorders, and other neurodegenerative conditions. An international team led by Mount Sinai School of Medicine scientists found that latrepiridine, known commercially as Dimebon, reduced the level of at least two neurodegeneration-related proteins in mice.

Latrepirdine was initially sold as an antihistamine in Russia, following its approval for use there in 1983. In the 1990s, the compound appeared effective in treating some of the earliest animal models of Alzheimer's disease. In a high profile Phase II clinical trial in Russia, overseen by a panel of top U.S. clinical trial experts, including Mount Sinai's Mary Sano, PhD, Professor of Psychiatry and Director of the Mount Sinai Alzheimer's Disease Research Center, latrepirdine showed significant and sustained improvement in cognitive behavior in Alzheimer's patients with minimal side effects. However, when the drug was tested in the U.S. in a Phase III trial, it did not demonstrate any improvement in people with the disease, causing the sponsors to halt further clinical study of the drug in Alzheimer's disease.

Before the failed trials however, Mount Sinai researchers led by Sam Gandy, MD, PhD, Professor of Neurology, and Psychiatry, and Director of the Mount Sinai Center for Cognitive Health, began studying how latrepirdine worked.

"Despite the failure to replicate the positive Russian trial results in U.S. patients, we found unexpected evidence that latrepirdine had potential as a treatment for a number of neurodegenerative disorders," said Dr. Gandy. "Our study shows that the compound prevents neurodegeneration in multiple ways and should remain a contender for battling these devastating diseases. The anti-amyloid approach most recently exemplified by reports that a second bapineuz
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Rejected Alzheimers drug shows new potential
2. Gay Adults Rejected by Parents Have Worse Health, Study Finds
3. New Vaccine May Offer Protection From Deadly Nipah Virus
4. Protein that boosts longevity may protect against diabetes
5. Can herbal products provide sun protection?
6. NIH team describes protective role of skin microbiota
7. Researchers developing bioadhesive gel to protect women from HIV and HSV infections
8. Aspirin protects against Barretts esophagus
9. Vitamin D may protect against lung function impairment and decline in smokers
10. High Blood Pressure May Protect Some Frail Elderly: Study
11. Protecting the hearts of those waiting for kidney and liver transplants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... , EAST LANSING, Mich. A team of researchers led ... million to identify risk factors for breast cancer in young ... during a woman,s lifetime. The five-year study, ... Ellen Velie of the College of Human Medicine,s Department of ...
... news release sent yesterday with the removal of the ... background treatments, and forced steroid taper poses an unacceptable ... from a 12-month multi-center clinical trial did not show ... non-life threatening systemic lupus erythematosus (SLE). Abatacept failed ...
... Meeting & OTO EXPO of the American Academy of Otolaryngology ... of ear, nose, and throat doctors in the world, will ... more than 305 scientific research sessions, 594 posters, and several ... a unique opportunity for journalists from around the world to ...
... At the UN Millennium Development Goals (MDG) summit in ... progress on the eight goals agreed in 2000 on ... summit came to a close, governments, businesses and aid ... with particular emphasis on improving maternal and child health. ...
... The loss of a gene known as INPP5A could predict ... of skin cancer, according to a study published today by ... Research Institute (TGen). Targeting INPP5A could provide physicians with ... or SCC, a skin cancer that often spreads to other ...
... scientists from Mayo Clinic, the University of Illinois at ... a long-standing research relationship to apply results from the ... for preterm birth. "This is a collaborative effort ... problems in maternal-fetal health," says Douglas Creedon, M.D., Ph.D., ...
Cached Medicine News:Health News:MSU researcher awarded $14 million to identify breast cancer risk factors 2Health News:Correction: Abatacept found ineffective in treatment of non-life threatening lupus 2Health News:Correction: Abatacept found ineffective in treatment of non-life threatening lupus 3Health News:2010 AAO-HNSF new research daily highlights: Wednesday, Sept. 29, 2010 2Health News:2010 AAO-HNSF new research daily highlights: Wednesday, Sept. 29, 2010 3Health News:2010 AAO-HNSF new research daily highlights: Wednesday, Sept. 29, 2010 4Health News:2010 AAO-HNSF new research daily highlights: Wednesday, Sept. 29, 2010 5Health News:International AIDS Society emphasizes universal access to HIV prevention, treatment and care as a prerequisite for improving maternal and child health 2Health News:International AIDS Society emphasizes universal access to HIV prevention, treatment and care as a prerequisite for improving maternal and child health 3Health News:TGen/Mayo Clinic/Arizona Cancer Center study finds gene associated with aggressive skin cancer 2Health News:TGen/Mayo Clinic/Arizona Cancer Center study finds gene associated with aggressive skin cancer 3Health News:Microbiomes may hold key to better understanding of preterm birth 2
(Date:12/24/2014)... , Dec. 23, 2014 Echo Therapeutics, ... device company focused on skin permeation, continuous glucose ... Scott W. Hollander has been appointed Chief ... has more than 20 years of experience in ... and most recently served as Vice President, Business ...
(Date:12/24/2014)... 2014   Synageva BioPharma Corp. (NASDAQ: ... therapeutic products for rare disorders, today announced validation ... Marketing Authorization Application (MAA) for sebelipase alfa for ... request for accelerated assessment, which has the potential ... The MAA, and the Biologics License ...
(Date:12/24/2014)... , Dec. 23, 2014 Tianyin Pharmaceutical ... that specializes in patented biopharmaceutical, modernized traditional Chinese ... (API) today announced that the Company achieved the ... Manufacturing Practice (GMP) certificate of TPI,s Qionglai Facility ... (CFDA). The public notice period is a significant ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3
... May 25 Two late-breaking clinical trials presented ... clinical data supporting Abbott,s market-leading XIENCE V® Everolimus Eluting ... of more than 5,000 real-world, complex patients, XIENCE V ... at one year (0.84 percent per Academic Research Consortium ...
... 24 At a town hall meeting a year ago, President Obama ... by keeping older people out of more expensive institutional care.  "I actually think ... it helps keep people in their homes," the president told his audience in ... , , ...
Cached Medicine Technology:New Data Reinforces Safety Profile of Abbott's Market-Leading XIENCE V(R) Drug Eluting Stent 2New Data Reinforces Safety Profile of Abbott's Market-Leading XIENCE V(R) Drug Eluting Stent 3New Data Reinforces Safety Profile of Abbott's Market-Leading XIENCE V(R) Drug Eluting Stent 4New Data Reinforces Safety Profile of Abbott's Market-Leading XIENCE V(R) Drug Eluting Stent 5Medicare Policies Ignore Aging-at-Home Concept 2Medicare Policies Ignore Aging-at-Home Concept 3Medicare Policies Ignore Aging-at-Home Concept 4Medicare Policies Ignore Aging-at-Home Concept 5
CCR Medical conventional laryngoscope handles....
... Wire-Reinforced LMA ™ Airway., ,The ... tube which allows it to be ... while maintaining a good seal. This ... and dental surgery, or other procedures ...
... Airway. , ,Developed for cardiopulmonary resuscitation ... the LMA Fastrach™ has been designed to ... or neck. The LMA Fastrach™ allows continuous ... by emergency teams worldwide including NASA for ...
... in the production of airway ... an integrated solution to all ... single-use Portex Soft Seal Laryngeal ... to this wide portfolio of ...
Medicine Products: