Navigation Links
Rejected Alzheimer's drug shows new potential
Date:7/31/2012

ion behind latrepirdine in the current study, which is supported by the Cure Alzheimer's Fund.

Dr. Gandy's team randomly administered either latrepirdine or placebo to mice engineered to present the early stages of Alzheimer's disease and found that the drug halted both behavioral decline and progression of neuropathology. In evaluating how latrepirdine improved memory, John Steele, PhD, a neuroscience graduate student working with Dr. Gandy, and Lenard Lachenmayer, MD, a postdoctoral fellow working under the supervision of Zhenyu Yue, PhD, Associate Professor of Neurology at Mount Sinai, found that the drug enhanced autophagy, the so-called "self-eating" process of cells that protects the brain from neurodegeneration.

"When we learned that latrepirdine failed in patients in the United States in 2010, scientists around the world were disappointed and perplexed," Dr. Gandy said. "We wanted to find out why the drug did so well in Russia but then showed no effect in the global studies. The findings from our animal model studies indicated that this drug should not be discarded, and that, if its mechanism of action can be optimized, it still has potential."

Dr. Sano points out that not only did latrepirdene have significant and sustained effect in the Russian study but it also showed a mild effect in one study of patients with Huntington's disease.

"Since cognitive benefit is what really matters to patients and families, it is critical that we explore every mechanism by which it might occur," Dr. Sano said.

"While this is just the beginning, our research shows that this previously cast-off drug still has strong therapeutic promise," Dr. Gandy said. "Autophagy drugs are believed to hold great promise for a range of neurodegenerative diseases, and these data raise the question of whether further basic science work on latrepirdine might lead to optimization of the drug so that a more potent drug could be developed, and sub
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Gay Adults Rejected by Parents Have Worse Health, Study Finds
2. Landmark HIV treatment-as-prevention study shows additional health benefits, cost-effectiveness
3. Weight Control Can Cut Womens Diabetes Risk, Study Shows
4. Mindfulness meditation reduces loneliness in older adults, Carnegie Mellon study shows
5. SEARCH study shows 1-year drop in HIV virus levels in rural Ugandan parish after campaign
6. Research shows potential of microneedles to target therapeutics to the back of the eye
7. 32-country study shows that type 2 diabetes drug is clinically effective for long-term use
8. Benefits of HIV drugs rise -- but less than previously believed, Penn study shows
9. Alzheimers Drug Shows Promise in Early Trial
10. Study shows colon and rectal tumors constitute a single type of cancer
11. Spouses of severe-sepsis patients at high risk of depression, U-M study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... LENEXA, Kan. (PRWEB) December 19, 2014 ... dedicated exclusively to healthcare providers, has been retained to ... for Johnson Memorial Hospital in Franklin, Ind. The top ... Smith has recently placed more than 900 healthcare executives ... 100-bed, county-owned, full service hospital providing care to the ...
(Date:12/19/2014)... Pain Free Living a leader in ... a new Superior magnetic necklace using ion ... strongest neodymium magnets for the fastest pain relief in ... Superior Magnetics brand for the fastest relief by using ... therapy using Superior Magnetic Jewelry at fairs and festivals” ...
(Date:12/19/2014)... After a 13-year absence from active touring, the ... stage to entertain his many worldwide fans. Trisha Yearwood ... successful tour has been steadily expanding since the very ... Ticketability.com for a large inventory of Garth Brooks ... , Music fans have had a long wait for ...
(Date:12/19/2014)... -- Being in good shape seems to reduce your risk ... data from more than 57,000 Americans, including more than 35,000 ... and 2009. Those in the poorest shape had a ... at the start of the study, compared to a 50 ... Of the more than 8,000 people diagnosed with high blood ...
(Date:12/19/2014)... By Randy Dotinga ... (HealthDay News) -- Common painkillers, including ibuprofen, might slightly ... cancer, researchers say. Use of ibuprofen (Advil, Motrin) ... squamous cell skin cancer by 15 percent, the researchers ... cancer is usually caused by sun exposure. ...
Breaking Medicine News(10 mins):Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 2Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 3Health News:New Superior Magnetic Necklace Relieves Migraine Headache 2Health News:Garth Brooks Tickets for Joe Louis Arena: Ticketability.com Becomes a Popular Destination for Discount Tickets for Garth Brooks’ Detroit Concerts Set for February 27-28 2Health News:Being Fit Keeps Blood Pressure in Check 2Health News:Common Painkillers May Help Prevent Certain Skin Cancers, Study Finds 2Health News:Common Painkillers May Help Prevent Certain Skin Cancers, Study Finds 3
... have multiple numbers of children. A latest study done by German ... of tumors in the brain, in the older children. The ... family. ,The study was based on the data ... brain tumor patients from Sweden. The results of the study were ...
... a novel finding, researchers using brain scans have uncovered ... disorder, better known as// hysteria. The study’s findings open ... neurological disorder in which a patient complains of symptoms, ... ,The study involved three women with ...
... Patients with obstructive sleep apnea (OSA) may improve their ... new study shows that the majority of patients// with ... memory performance after 3 months of optimal CPAP use. ... on CPAP adherence. Patients who used CPAP for at ...
... to a report, San Mateo Seniors quarantine 3 more medical ... reported more this year than the// past. ,San ... outbreak, which has already sickened dozens of people in a ... ill. The doctors added that the outbreak is being ...
... achieves sharp reductions in human immunodeficiency virus (HIV) levels, ... patients with HIV infection. ,If the good ... clearly be a welcome addition to the existing treatment ... new study, led by Dr Martin Markowitz of The ...
... high-level investigation report by some of Britain's leading scientists ... to improve human health and reduce deaths// from disease. ... added. ,While speaking on the use of ... said that ‘In some cases primates are essential to ...
Cached Medicine News:Health News:Memory Improves After Sleep Apnea Therapy 2Health News:Quarantine Hits 3 More Hospitals In San Mateo 2Health News:New Drug Offers Promise as Single Treatment for HIV 2Health News:Britain Scientists Support the Use of Primates in Research 2
(Date:12/17/2014)... , Dec. 17, 2014 PCCA received ... ( http://bit.ly/1382OkS ) program seal for best ... The program highlights medical practices, materials and goods ... friendly." Children affected by autism often ... be exacerbated by ingredients found in food and ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research ... announced the addition of the "MEMS Gyroscopes ... Costing Analysis" report to their offering. ... MEMS gyroscopes for tactical grade applications made a ... in term of reliability. They are now accepted ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research and ... addition of the "Inferior Vena Cava (IVC) Filters ... to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... sector is projected to reach US$435 million by 2016. ... nearly 39% (2015) of the global value while ...
Breaking Medicine Technology:Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 2Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 3MEMS Gyroscopes Analog Devices ADIS16136 Precision Angular Rate Sensor Reverse Costing Analysis 2Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 2Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 3Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 4
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: