Navigation Links
Regulatory immune cell diversity tempers autoimmunity in rheumatoid arthritis
Date:5/8/2012

of death.

While the exact cause of RA is unknown, the Caton laboratory and others have shown that a variety of white blood cells called regulatory T cells (or Tregs) are a necessary component to either restrain (or encourage) the immune system's inflammatory response. Tregs are activated as molecules on their surface membranes called T cell receptors interact with "friendly" or "self" moleculesa way for the immune system to recognize friend from foe. Mismanagement of these Tregs, which normally serve to restrain the immune system from over-reacting to healthy tissue, could then lead to runaway inflammation.

In this study, the researchers sought to examine how T cell receptors affect the ability of Tregs to suppress arthritis in a mouse that had been bred to express a "self" molecule that drives arthritis. They showed that an array of Tregs given to the mice effectively stops arthritis. Unexpectedly, however, Tregs that are specific for the surrogate "self" molecule do not prevent arthritis.

"We find that the Treg responsible for recognition of the disease-initiating self antigen are sufficient for stopping arthritis, but a diverse repertoire of Tregs are very effective," Caton said. "All of these Tregs, together, influence other components of the immune system which serves to slow down the inflammatory process that causes RA."

According to Caton, their findings also point to a possible answer of why the immune system targets the membranes that line joints. Tregs influence other types of T cells to produce a substance known as IL-17, and these cells often travel through the body's lymphatic system where they then drain out into the joints.

"The big unanswered question of RA is 'why are joints targeted?'" Caton said. "Of all the tissues in the body, of all the places our immune system could attack, this question remains."

"One idea is that the immune system isn't deliberately attacking joints in patients with rhe
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Regulatory enzyme overexpression may protect against neurodegeneration in Huntingtons disease
2. Moffitt Cancer Center researchers find regulatory T-cell clue to help prevent GVHD
3. FDA awards Georgetown University a Center of Excellence in Regulatory Science & Innovation
4. Key regulatory genes often amplified in aggressive childhood tumor of the brainstem
5. FDA should invest in developing a new regulatory framework to replace flawed 510(k) medical device clearance process
6. Specialized regulatory T cell stifles antibody production centers
7. Newly discovered regulatory mechanism essential for embryo development and may contribute to cancer
8. “Global Supply Chain Visibility and Security; Business Necessity, Regulatory Imperative”
9. RAPS Seeks Nominations for Regulatory Awards, RAPS Fellows
10. iSirona Appoints Chief Quality and Regulatory Officer to Oversee Quality Initiatives
11. NIH-FDA Joint Briefing on Regulatory Science Collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... (PRWEB) August 01, 2014 Hot off the ... destination spa category of the World’s Best Awards by ... a month-long celebration of National Relaxation Day (technically August 15). ... series of MAJOR experts to help guests celebrate relaxation throughout ... it is for health and wellness to carve out time ...
(Date:8/1/2014)... HealthDay Reporter FRIDAY, Aug. 1, ... a time-honored destination for a good cut and conversation. ... be the spot to tackle an often overlooked health concern: ... partnership, the U.S. Centers for Disease Control and Prevention, together ... help of barbershop staff to both discuss and diagnose high ...
(Date:8/1/2014)... 2014 For years, proponents have praised ... study conducted by the Ohio State University, ... behind in terms of their health and development, raising ... best for their baby. So does this new research ... Steven Shapiro , chair of Pediatrics at Abington Memorial ...
(Date:8/1/2014)... GlobalDatas new report, "United ... provides key market data on the United ... value, in millions of US dollars, volume ... dollars) within market segments - Electrosurgical RF ... Plasma Coagulation Generators. , To view the ...
(Date:8/1/2014)... -- Women who serve in the U.S. military are ... a new study suggests. Overall, members of the ... researchers found that women respond differently to their experience ... to concerns about sexual harassment or being treated unfairly, ... sexual assault, both within and outside the military, and ...
Breaking Medicine News(10 mins):Health News:The Lodge at Woodloch Kicks Off National Relaxation Day with a Month Long Celebration 2Health News:The Lodge at Woodloch Kicks Off National Relaxation Day with a Month Long Celebration 3Health News:The Lodge at Woodloch Kicks Off National Relaxation Day with a Month Long Celebration 4Health News:Barbershops Join Fight Against High Blood Pressure in Black Men 2Health News:Barbershops Join Fight Against High Blood Pressure in Black Men 3Health News:Despite Recent Study, Abington Health Expert Encourages Breastfeeding 2Health News:Despite Recent Study, Abington Health Expert Encourages Breastfeeding 3Health News:United Kingdom Surgical Generators Market Size, Share, Analysis, Trends and Forecasts 2020 2Health News:United Kingdom Surgical Generators Market Size, Share, Analysis, Trends and Forecasts 2020 3Health News:Women in Military Drink Less Than Civilians, Report Shows 2
... of the most aggressive cancers worldwide and its incidence is ... infection and aflatoxin contamination of foodstuffs. The cancer is also ... and China have been studying gene activity in liver tumors ... of detecting tumors that spread. They found that there is ...
... born during night time have a higher risk of ... day time. Previous studies have also shown that infants ... an increased risk of death at birth, urging the ... obstetric and neonatal care during the night. Researchers conducted ...
... been believed, over the years, to be a potential cure against ... true by researchers who have studied changes in immune cells' response ... 12 healthy subjects who took one gram of vitamin C a ... in all of them during the period. Their finding(in two patients) ...
... from The Forsyth Institute in Boston and the University of ... of the Journal of Microbiology that bad breath or halitosis ... back portion of the top of your tongue. The study ... the tongues of those with halitosis and those with fresh ...
... of the long-running Framingham Heart Study have now found ... levels of homocysteine, an amino acid whose build-up has ... and dementia, increases the risk of developing congestive heart ... age 72 years, who were studied during 1979 to ...
... researchers in the Journal of Hypertension indicates that ... improve their atherosclerotic risk profile by consuming alcohol ... serum lipoprotein(a), a powerful predictor of organ damage, ... studied 402 patients with untreated essential hypertension to ...
Cached Medicine News:Health News:Germs to blame for bad breath 2
(Date:8/1/2014)... In the latest call for gender equity ... than 60 doctors and leading medical experts from across ... Food and Drug Administration,s (FDA) decision to approve 26 ... sexual dysfunction compared with ZERO for women,s most common ... women by approving the first-ever drug to treat Hypoactive ...
(Date:8/1/2014)... DALLAS , August 1, 2014 ... Care Market by Type (Traditional Wound Closure, Anti infective), ... Active (Artificial Skin & Skin Substitutes), Pressure Relief ... by MarketsandMarkets, the global Wound Care Market is expected ... Billion in 2014, growing at a CAGR of ...
(Date:8/1/2014)... PLYMOUTH MEETING, Pa. , Aug. 1, 2014 /PRNewswire/ ... that it will host a conference call to report ... 11, 2014 at 9:00 AM ET. CEO Dr. ... will discuss second quarter earnings, provide a corporate ... The update will include clinical development plans for VGX-3100, ...
Breaking Medicine Technology:60+ Doctors and Leading Medical Experts Sign an Open Letter Urging the FDA to Approve First-Ever Drug to Treat Women's Most Common Form of Sexual Dysfunction, notes Even the Score 260+ Doctors and Leading Medical Experts Sign an Open Letter Urging the FDA to Approve First-Ever Drug to Treat Women's Most Common Form of Sexual Dysfunction, notes Even the Score 3Wound Care Market Worth $18.3 Billion by 2019 2Wound Care Market Worth $18.3 Billion by 2019 3Inovio Pharmaceuticals to Host Second Quarter 2014 Financial Results Call on August 11, 2014 2Inovio Pharmaceuticals to Host Second Quarter 2014 Financial Results Call on August 11, 2014 3
... , CHANGCHUN, China and LOS ... Bulletin Board: CYXN) ("Yongxin" or,"the Company"), a leading pharmaceutical ... the third quarter ended,September 30, 2009. , ... products depend on discretionary,spending, we expect as the economy ...
... , MINNEAPOLIS, Dec. 10 Uroplasty, Inc. ... that develops, manufactures and markets innovative proprietary products to ... the OrBIT Trial of its Urgent® PC Neuromodulation System ... edition of THE JOURNAL OF UROLOGY® . The ...
Cached Medicine Technology:China Yongxin Pharmaceuticals, Inc. Announces Results for the Third Quarter Ended September 30, 2009 2China Yongxin Pharmaceuticals, Inc. Announces Results for the Third Quarter Ended September 30, 2009 3China Yongxin Pharmaceuticals, Inc. Announces Results for the Third Quarter Ended September 30, 2009 4China Yongxin Pharmaceuticals, Inc. Announces Results for the Third Quarter Ended September 30, 2009 5China Yongxin Pharmaceuticals, Inc. Announces Results for the Third Quarter Ended September 30, 2009 6China Yongxin Pharmaceuticals, Inc. Announces Results for the Third Quarter Ended September 30, 2009 7China Yongxin Pharmaceuticals, Inc. Announces Results for the Third Quarter Ended September 30, 2009 8OrBIT Study Long Term Results Show Sustained Therapeutic Effect of Percutaneous Tibial Nerve Stimulation at 12 Months 2OrBIT Study Long Term Results Show Sustained Therapeutic Effect of Percutaneous Tibial Nerve Stimulation at 12 Months 3OrBIT Study Long Term Results Show Sustained Therapeutic Effect of Percutaneous Tibial Nerve Stimulation at 12 Months 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: