Navigation Links
Regulatory B cells exist -- and pack a punch
Date:5/27/2008

like contact hypersensitivity.

Now that we have been able to identify this regulatory B cell subset, we have already developed treatments that deplete these cells in mice. We are moving to translate these findings to benefit people, he said.

The discovery of the ability to identify this potent regulatory cell type should provide important clues to how the immune system regulates itself in response to vaccines as well as infectious agents, says Barton F. Haynes, M.D., leader of the international Center for HIV/AIDS Vaccine Immunology (CHAVI), a consortium of universities and academic medical centers, and director of the Duke Human Vaccine Institute. This information should enable researchers to design ways to help the immune system control infections more effectively, and could be a useful advance as we refine approaches to preventing HIV infection.

Theres a huge initiative underway to look at regulatory T cells in autoimmune disease, HIV infection, and cancer therapy, Tedder said. What we have also shown is that it is not only regulatory T cells, but also regulatory B cells that could prevent a person from making effective immune responses in HIV and many other diseases, particularly cancer.

The Duke researchers developed a way to mark the B10 cells so that they could see that just these cells were producing IL-10. Previously, scientists could only purify a population of B cells and see whether IL-10 could be produced by some of these cells in the population.

In this study, they found that the B10 cells represented only 1-2 percent of all of the B cells in the spleen of a normal mouse. Before this, no one had definitively identified this B cell subset or such regulatory B cells in normal mice, although B cell regulatory function had been described in some genetically altered mice with chronic inflammation.

In this study, we could directly look at the B cells that were producing IL-10, and figure out what their
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Cipher provides regulatory update for CIP-TRAMADOL ER
2. Cynosures Accolade(TM) Workstation for Pigmented Lesions Receives Korean Regulatory Approval
3. Jane Moffitt, J.D., LL.M. Named Vice President of Regulatory Affairs of Nile Therapeutics
4. Medpace Director of Clinical Pharmacology, Jim Wei, MD, PhD, Embarks on a Regulatory Policy Speaking Tour in China in May
5. GlaxoSmithKline Confirms Receipt of FDA Letter on Regulatory Reporting
6. New regulatory circuit identified for aggressive, malignant brain tumor
7. Biopure Receives Comment Letter From U.K. Regulatory Body on Marketing Application for Hemopure(R)
8. Alsius Corporation Receives Regulatory Approval in China and Mexico
9. InnerPulse, Inc. Appoints Elsa Chi Abruzzo as Vice-President of Regulatory and Quality Affairs
10. CSHL scientists discover new details of a gene-regulatory network governing metabolism
11. Legislative and Regulatory Outlook - 2009 and Beyond for Pharma, Biotech Players
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... July 24, 2014 (HealthDay News) -- Women who compete ... disorders, including incontinence, and other health problems, a new ... popularity of high-impact sports such as triathlons, but little ... pelvic health and certain other issues associated with endurance ... physiatrist at Loyola University Health System, said in a ...
(Date:7/25/2014)... initial romantic encounters determine the fate of a potential ... necessary to fuel sexual desire and land a second ... for both men and women on a first date. ... Do men perceive responsive women as more attractive, and ... men? A study published in Personality and Social ...
(Date:7/25/2014)... 25, 2014 The Futon Shop ... Futon Sale. The Futon Shop has been around since 1976 ... has grown from a few handmade futon mattresses a month, ... of futon mattresses. , The Futon Shop futon mattresses ... the desire to sleep on natural fibers was a growing ...
(Date:7/25/2014)... July 25, 2014 Stwd.co.uk, one of ... new collection of cheap evening dress for ... launch a big promotion for these items. They are ... promotion will last until August 30. , “We are ... Beside evening outfits, we have a large number of ...
(Date:7/25/2014)... Mirada (PRWEB) July 25, 2014 ... La Mirada clinic is offering Occupational Medicine ... Center is happily accepting referrals and workers’ compensation ... the La Mirada clinic include wound care treatment ... and ergonomic assessments, pre-employment screening & physicals, and ...
Breaking Medicine News(10 mins):Health News:Female Triathletes May Face Health Problems Such as Incontinence 2Health News:Why do men prefer nice women? 2Health News:Why do men prefer nice women? 3Health News:Organic Mattress Manufacturer Celebrates 38 Years Of Being In Business 2Health News:Organic Mattress Manufacturer Celebrates 38 Years Of Being In Business 3Health News:Famous Supplier Stwd.co.uk Announces Its New Selection of Evening Dresses for Women 2Health News:Healthpointe Offering Occupational Medicine Services in La Mirada 2
... of deep concern and disappointment about reports that the ... issues that are critical to access to care for ... the American College of Physicians (ACP). David C. ... behalf of the 124,000 internal medicine physicians and medical ...
... Supplier, WAKEFIELD, Mass., Sept. 21 Friends ... research and programs,today announced that it is recalling ... to donors who contribute to its cancer-related programs. ... supplier that the,bracelets did not contain lead. When ...
... and treatments to save dogs,from cancer and the benefits ... subject of a news report that debuted on ABC ... picked up by about 15,stations nationwide, detailed the innovative ... the University of California-Davis and,being funded and supported by ...
... is a,statement by Robert Greenstein, executive director of ... new congressional SCHIP agreement:, "Today,s agreement would ... a major accomplishment. Contrary to White,House rhetoric, the ... are poor,and near-poor children who are uninsured, not ...
... patients with incurable disease fared better, doctor says , FRIDAY, ... tumors may help improve treatment for some patients with incurable ... president of Oncology Care Associates in St. Joseph, Mich., had ... drugs might offer them the most benefit, Lester used DNA ...
... 20 -- A new study led by investigators from the ... of necrosis, long thought to be a chaotic, irreversible pathway ... a regulated response to stress by a powerful protein, SRP-6, ... research team realized that this protein might be harnessed to ...
Cached Medicine News:Health News:'Deep concern and disappointment' with exclusion of Medicare from SCHIP legislation 2Health News:'Deep concern and disappointment' with exclusion of Medicare from SCHIP legislation 3Health News:Friends of Mel Announce Recall of Jewelry Due to Lead 2Health News:Friends of Mel Announce Recall of Jewelry Due to Lead 3Health News:ABC TV San Francisco Features Canine Cancer Research Story: Saving Our Dogs, Helping Humans Beat Cancer - Work at Morris Animal Foundation, UC-Davis 2Health News:Statement by Robert Greenstein, Executive Director of the Center on Budget and Policy Priorities, on the New Congressional SCHIP Agreement 2Health News:Pathway to cell death redefined in landmark study 2Health News:Pathway to cell death redefined in landmark study 3Health News:Pathway to cell death redefined in landmark study 4
(Date:7/25/2014)... /PRNewswire-iReach/ -- Dr. Michael Gabriel of a prominent ... a recent study, which shows how grief in pregnancy may ... According to US News , ... likely than others to grow up overweight or obese, even ... were two specific types of stress that caused obesity: "Children ...
(Date:7/24/2014)... 24, 2014  Parnell Pharmaceuticals Holdings Ltd announces ... be added to Parnell,s already extensive pipeline through ... a biotechnology company. The compounds now known as ... in bone regeneration and dermal regeneration, respectively. Parnell ... for the veterinary market with the potential to ...
(Date:7/24/2014)... Wis. , July 24, 2014  Restore ... specialty and compounded pharmaceuticals, announced that it is ... information unique to each individual based upon their ... possible by understanding the interaction between a patient,s ... "We,re very excited to provide this new ...
Breaking Medicine Technology:Dr. Michael Gabriel of GPM Pediatrics, a Noted Staten Island Pediatrics Clinic, Comments on Study, Which Names Grief as a Cause of Obesity in Children 2Parnell Acquires License for Intellectual Property and Rights to Develop Compounds for Bone and Dermal Regeneration 2Parnell Acquires License for Intellectual Property and Rights to Develop Compounds for Bone and Dermal Regeneration 3Parnell Acquires License for Intellectual Property and Rights to Develop Compounds for Bone and Dermal Regeneration 4Restore Health Launches Pharmacogenetic Testing, Enhancing Its Suite of Personalized Medicine Goods and Services 2Restore Health Launches Pharmacogenetic Testing, Enhancing Its Suite of Personalized Medicine Goods and Services 3
... Neuralstem, Inc. (NYSE Amex: CUR ) updated the ... the company,s spinal cord stem cells in the treatment of ... University in Atlanta, Georgia. The company announced that, after reviewing the ... Monitoring Board has unanimously approved moving to the last group ...
... Science Corporation , a global leader in automated external defibrillator ... has been awarded a contract to deploy Powerheart® AEDs at ... Postal Inspection Service is the primary law enforcement arm of ... to have been selected to protect the men and women ...
Cached Medicine Technology:Neuralstem Updates ALS Clinical Trial Progress 2Neuralstem Updates ALS Clinical Trial Progress 3Neuralstem Updates ALS Clinical Trial Progress 4U.S. Postal Inspection Service Awards AED Contract to Cardiac Science 2U.S. Postal Inspection Service Awards AED Contract to Cardiac Science 3U.S. Postal Inspection Service Awards AED Contract to Cardiac Science 4
... Basic ergonomic chairs with concave seats ... • Select options like seats, backrests, ... BTC/1Q chairs are recommended for the ... room, static control, health care and ...
... ergonomic chairs with concave seats and ... Select options like seats, backrests, armrests, ... chairs are recommended for the following ... static control, health care and office. ...
... Basic ergonomic chairs with concave ... support • Select options like seats, ... are recommended for the following environments: ... control, health care and office. • ...
... Basic ergonomic chairs with ... with lumbar support • Select ... and casters and glides. • ... the following environments: industry, education, ...
Medicine Products: