Navigation Links
Regulation by proteins outside cancer cells points to potential new drug target
Date:7/9/2012

SAN ANTONIO (July 9, 2012) Protein interactions outside breast cancer cells can send signals to the cancer cells to permanently stop proliferating, a new study showed in the School of Medicine at The University of Texas Health Science Center San Antonio.

"Because this protein cascade is outside the cells, it is likely amenable to therapeutic manipulation," said lead author Yuzuru Shiio, M.D., Ph.D., assistant professor of biochemistry at the university's Greehey Children's Cancer Research Institute. "I hope our study will ultimately lead to a therapeutic strategy to reprogram cancer cells to a state of permanent dormancy."

He cautions that the finding was observed in cell cultures and is still far from human cancer therapy. Dr. Shiio is also a member of the Cancer Therapy & Research Center (CTRC) at the UT Health Science Center, a National Cancer Institute Designated Cancer Center.

Senescence is poorly understood

Upon successful chemotherapy, cancer cells either die or permanently stop proliferation. The latter phenomenon is called senescence and is poorly understood, Dr. Shiio said.

Using cultured breast cancer cells as a model, the team found that upon chemotherapeutic drug treatment these cells released factors that stop proliferation. By analyzing which proteins are released under this stress, the team discovered that a protein called IGFBP3 (insulin-like growth factor binding protein 3) is a key player in cancer senescence. The team then studied other proteins that work together with IGFBP3 outside of the cancer cells.

Needle in a haystack

Using powerful, large-scale analysis called proteomics, the researchers literally picked out the increased abundance of this one protein, IGFBP3, among a thousand other proteins outside of the cells. It was like finding a proverbial needle in a haystack.


'/>"/>
Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Page: 1

Related medicine news :

1. Warwick scientists uncover how checkpoint proteins bind chromosomes
2. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
3. Overexpression of proteins 14-3-3 related to chemotherapy resistance
4. The key (proteins) to self-renewing skin
5. Study Suggests Vaccine May Help Kids With Brain Cancer
6. New Stool Test Might Aid in Early Detection of Colon Cancer
7. Study reveals how cancer drug causes diabetic-like state
8. How a cancer drug leads to diabetes
9. You Survived Cancer: Now Pay Attention to Your Overall Health
10. New drug prevents spread of human prostate cancer cells
11. Eliminating the good cholesterol receptor may fight breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... May 27, 2016 , ... With ... pharmaceutical, medical and food industries. Aside from its GMP accreditation, Validation Center is ... of successfully certified products, services and staff. , Validation Center is ISO17025 accredited ...
(Date:5/26/2016)... Louis, Missouri (PRWEB) , ... May 26, 2016 ... ... cost, quality and clinical outcomes, hosted members and suppliers for its inaugural Member ... a focus on their mission of elevating the operational health of America’s healthcare ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... that has a significant negative impact on long-term patient survival, reports a team ... results, published online this week in the Journal of Thoracic and Cardiovascular Surgery, ...
(Date:5/26/2016)... ... , ... An April Gallup survey found rising health care costs to be ... Health Senior Living (SHSL) may not share those same worries thanks to a ... the year, while holding the line on increasing their contributions, including premiums, deductibles and ...
(Date:5/26/2016)... , ... May 26, 2016 , ... The Lung ... host a six-week smoking cessation class starting June 6 at their clinic in downtown ... http://www.gnahec.org . , Additionally, the Lung Institute has created a free downloadable 4 Week ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 ... 2016"market research report that provides an overview on ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ... reviews key players involved in the therapeutic development ...
(Date:5/24/2016)...   , Study met both ... superiority in , Excellent plus Good ... of the ascending colon   , ... today announced new positive data from the phase III MORA study ... 2 litre PEG with ascorbate. The study met both primary endpoints ...
(Date:5/24/2016)... , May 24, 2016 Celsion Corporation ... development company, today provided an update on its ... clinical trial combining GEN-1, the Company,s DNA-based immunotherapy, ... of newly-diagnosed patients with advanced ovarian cancer who ... surgery.  GEN-1 is an IL-12 DNA plasmid vector ...
Breaking Medicine Technology: