Navigation Links
Regulating the sugar factory in diabetes
Date:5/21/2009

Scientists in Sydney and Boston believe they may have identified a gene that controls abnormal production of sugar in the liver, a very troublesome problem for people with diabetes.

The liver is the sugar factory for the body - when blood sugar (glucose) levels fall, the liver makes and releases more. In people with diabetes, especially Type 2 diabetes, the liver doesn't stop making sugar when it should, so blood sugar levels can rise overnight while they sleep even though they haven't eaten.

Dr Jenny Gunton, diabetes specialist and endocrinologist from Sydney's Garvan Institute of Medical Research, in collaboration with Dr Xiao Hui Wang and Professor Ronald Kahn from Harvard Medical School and Joslin Diabetes Centre in Boston, have published their findings in the journal Cell Metabolism, now online.

"A lot of my patients will complain that they go to bed with a blood sugar of 5 and wake up with a blood sugar of 12," said Dr Gunton.

"It upsets people when their blood sugar behaves as if they're getting up in the night and having a really big snack. I have to tell them it's just one of those unfair things about having diabetes."

People with Type 2 diabetes do not produce enough insulin in the pancreas after a meal. At the same time, they are less able to use that insulin to move glucose into fat and muscle cells, a condition known as 'insulin resistance'.

With her colleagues in Boston, Gunton has been studying a transcription factor, or kind of 'master regulator', called ARNT, which controls expression of other genes involved in processes like glucose breakdown and insulin production. In an earlier study, the group showed that there is 90% less ARNT in insulin-producing cells of people with Type 2 diabetes.

The current study looks at how ARNT might be affecting the liver, and its results confirmed Dr Gunton's suspicions. "We've shown that there's likely to be decreased ARNT in the liver of people with Type 2 diabetes compared to people without Type 2 diabetes," she said.

"Working with mice, we found that glucose levels were elevated and there was glucose production from a 'precursor', a source not normally metabolised."

Other results in the study show that to some extent ARNT is regulated by insulin, so that insulin resistance in itself will contribute to a decrease in ARNT. If liver cells are treated with insulin, there will be a small increase in ARNT protein. The insulin will also help move the ARNT into the nucleus of the cell, where it does its job as a master regulator.

The paper concludes that a decline in ARNT isn't limited to the beta cells of people with Type 2 diabetes. ARNT is also reduced in other important diabetes-related tissues like the liver.

Dr Gunton believes that if a new drug could be developed to increase ARNT activity in the liver, then it may be possible to shut down abnormal sugar production and improve blood sugar control in people with diabetes.


'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-299-801-224
Research Australia
Source:Eurekalert

Related medicine news :

1. Emilys Law for Regulating Pharmacy Technicians Signed by Ohio Governor
2. Scientists ID Gene Regulating Blood Glucose Levels
3. Photo: Levemir(R) Once-Daily Substantially Lowered Average Blood Sugar Levels of Patients with Type 2 Diabetes in TITRATE(R) Study
4. Healthy Living Network Announces Launch of New Blood Sugar Web Site
5. Landmark NBC News Nutrition Report: There Is Indeed Little Difference Between High Fructose Corn Syrup and Table Sugar
6. New Research Unveils That Pistachios May Lower Risk of Type 2 Diabetes by Improving Blood Sugar Levels
7. Halting Avandia Use Hikes Blood Sugar Levels
8. Severe Low Blood Sugar Ups Older Diabetics Dementia Risk
9. Low Blood Sugar Events Increase Dementia Risk in Elderly Patients With Type 2 Diabetes, Kaiser Permanente Study Finds
10. Fewer Sugary Drinks Key to Weight Loss
11. Study Links Sugar Production in Yeast Cells to Longevity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... ... is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and ... that call for a minimum wage raise to $12 an hour by 2020 and then ... will restore the lost value of the minimum wage, assure the wage floor does not ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... OAKLAND, N.J. , June 24, 2016 /PRNewswire/ ... in the design, development and manufacturing of collagen ... and regeneration announced today that Bill Messer ... Sales and Marketing to further leverage the growing ... surgery medical devices. Bill joins the ...
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ... company developing innovative inhaled drugs, announced today that it ... Russell Investments reconstituted its comprehensive set of U.S. ... "This is an important milestone for Pulmatrix," said ... increase shareholder awareness of our progress in developing drugs ...
Breaking Medicine Technology: