Navigation Links
Regular exercise beneficial in suppressing inflammation in rheumatic disease

Research findings presented today at the European League Against Rheumatism Annual Congress (EULAR 2014) suggest that exercise transiently suppresses local and systemic inflammation, reinforcing the beneficial effects of exercise and the need for this to be regular in order to achieve clinical efficacy in rheumatic disease.

Chronic inflammation, swelling and pain in the joints characterise the more than 200 rheumatic diseases. Persistent inflammation over time can damage affected joints, but previous research has established that exercise can decrease joint inflammation in rheumatoid arthritis.

These new research findings focused on the physiological changes created by exercise and their impact on inflammation. The researchers have found that exercise generates a true biological response and induces changes on a molecular level that stimulate anti-inflammatory effects.

"As the inflammatory process in rheumatic diseases is a major cause of disability, we are excited to uncover the process by which exercise works on a molecular level to decrease this inflammation. Our results show the benefits that exercise could have in decreasing the great burden of rheumatic diseases. They also highlight the need for frequent exercise in order to create clinically significant results," said Dr. Nicholas Young, presenting author from The Ohio State University Wexner Medical Center, Columbus, Ohio, US.

This in-vivo study measured the regulation and activation of NF-kB* in mice. NF-kB, a protein complex that controls many genes involved in inflammation, is found to be chronically active in many inflammatory diseases, such as inflammatory bowel disease and arthritis.

An inflammatory response was created in mice both before and after exercise through an injection of lipopolysaccharides (LPS). The impact of exercise was measured over time following the inflammatory response.

There was a strong systemic and local inflammatory response upon injection of LPS, which was strongest at 2 hours post-injection. NF-kB activation was seen as a result of the LPS and was detected in lymphatic tissues throughout the mouse. In those groups where mice were exercised pre- and post-LPS injection, the NF-kB activation was significantly inhibited in whole-body systemic analysis.

The effect of exercise on the inhibition of NF-kB activation was identified as a transient effect, lasting only 24 hours after exercise.

The role of exercise in inhibiting NF-kB activation was linked to the suppression of multiple pro-inflammatory cytokines. Cytokines are produced by a wide range of cells including macrophages and are involved in cell signalling.

Rheumatic disease is a term used to describe over 200 conditions characterised by inflammation, swelling and pain in the joints or muscles. They are leading causes of morbidity and disability, giving rise to enormous healthcare expenditures and loss of work.

Contact: EULAR Press Office
European League Against Rheumatism

Related medicine news :

1. Seniors who exercise regularly experience less physical decline as they age
2. Army drug users twice as likely to use synthetic marijuana as regular marijuana
3. Regular doctor visits may greatly diminish skin cancer deaths
4. Dipping blood sugars cause surprisingly irregular heart rhythms in diabetics
5. Regular physical activity reduces breast cancer risk irrespective of age
6. Women’s Excellence Now Scheduling Annual Gynecological, Preconception and Prenatal Visits in Birmingham, Michigan; Regular Healthcare Visits Can Decrease Birth Defects
7. Regular cocaine and cannabis use may trigger addictive behaviors
8. Maintaining a Schedule of Regular Meals is Crucial While Dieting
9. Irregular Heartbeat May Speed Memory Loss in Seniors
10. Irregular Menses and Pain Caused by Adenomyosis or Endometriosis Can Be Improved with Herbal Therapy without Pain Killers & Surgeries - Wuhan Dr. Lee’s TCM Clinic
11. Omega3 Innovations Launches a New Omega Passion Chocolate Truffle to Replace Regular Fish Oil Capsules
Post Your Comments:
(Date:10/13/2015)... ... 13, 2015 , ... According to an article published October 5th ... who successfully lose weight with a bariatric procedure are much less likely to develop ... notes that anywhere from 40 to 50 percent of all endometrial cancer cases are ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... In an ... utility costs were 36 percent lower per square foot than in 2009. The Williamsport ... cost of heating and cooling has decreased by eight percent. , According to ...
(Date:10/13/2015)... ... ... A child without a healthy mouth is much more likely to have an ... has joined with Global Dental Relief (GDR) to help bring dental care ... SmileCareClub will donate one clinic visit to a child in Kenya. , “When SmileCareClub ...
(Date:10/13/2015)... ... 13, 2015 , ... Scientists in Seattle and Vancouver compared the diagnostic value ... without mesothelioma. Surviving Mesothelioma has just posted an article on the new research. ... Seattle and the University of British Columbia found that certain genetic alterations were seen ...
(Date:10/13/2015)... , ... October 13, 2015 , ... World Patent ... Snow Blanket, a snow melting invention that helps people in clearing snow away from ... will continue to grow at 3.8% per year," says Scott Cooper, CEO and Creative ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)...  Synapse Biomedical Inc. ( ) reported today ... the use of the NeuRx ® Diaphragm Pacing ... the United States and ... The PAS study group met their initial enrollment goal ... since expanded the enrollment target to 150 participants.   ...
(Date:10/13/2015)... , Oct. 13 2015 ... the "US & European markets for Meniscal ... their offering. --> ) has ... European markets for Meniscal Repair - 16 Countries ... Research and Markets ( ) has ...
(Date:10/13/2015)... Research and Markets ( ) has ... Types (Bacteria, Yeast, Mold, Others), Flavors (Herbs & Spices, ... by Region - Forecasts to 2020" report to ... --> The global market for kombucha ... terms of value, the market is projected to reach ...
Breaking Medicine Technology: