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Regenerative Medicines: Bone and Joint Applications
Date:9/19/2013

br />CREATION OF ENTIRE ORGANS 51
EMBRYONIC STEM CELLS 52
NOVEL MATERIALS AND BIOMATERIALS 53

CHAPTER 6 STEM CELL THERAPIES AND REGENERATIVE MEDICINE 56

STEM CELLS AS POTENTIAL REPLACEMENT CELLS 56
OVERALL MARKET AND PARTICIPANTS 57
STEM CELL MARKET RISKS 57
TECHNICAL IMPEDIMENTS 58
OVERVIEW OF FUNDING 58
TABLE 12 FEDERAL FUNDING FOR STEM CELL RESEARCH THROUGH 2012 ($
MILLIONS) 59
STATE-LEVEL INITIATIVES FOR STEM CELL RESEARCH 59
TABLE 13 STATE LEVEL PROGRAMS FOCUSED ON STEM CELL RESEARCH 60
POTENTIAL APPLICATIONS: CURRENT STATUS 60
IN VIVO REPROGRAMMING 61
UMBILICAL CORD BLOOD STEM CELLS 61
Recent Research Developments 62
INDUCED PLURIPOTENT STEM CELLS 62
Recent Research Developments 62
Adult Multipotent Stem Cells 63
Embryonic Stem Cells 63
Adipose Stem Cells for Bone and Joint Applications 65
GERON AND THE FIRST HUMAN TRIALS 66
OTHER STEM CELL RESEARCH 68
STATUS OF OTHER CLINICAL TRIALS 68
STEM CELL THERAPY FOR ALS 69
STEM CELL THERAPY FOR DUCHENNE MUSCULAR DYSTROPHY 70
STEM CELL THERAPY AND BONE MARROW TRANSPLANTS 71

CHAPTER 7 REGENERATIVE PRODUCTS TO TREAT BONE DISEASES 74

REGENERATIVE PRODUCTS TO TREAT BONE DISEASES 74
OSTEOBIOLOGICS 74
BONE GRAFTS 75
PRINCIPAL USES OF BONE GRAFTS 75
TABLE 14 CHARACTERISTICS OF IDEAL BONE GRAFT MATERIAL 76
TABLE 15 U.S. BONE GRAFT PROCEDURE VOLUMES BY APPLICATION, THROUGH
2018 77
TABLE 16 U.S. BONE GRAFT PROCEDURE VOLUMES BY TYPE OF GRAFT, THROUGH
2018 77
TABLE 17 BONE GRAFT MATERIALS 78
TABLE 18 SUBSTITUTE BONE GRAFTS 80
AUTOGRAFTS 80
BIOSEED GRAFTS 81
ALLOGRAFTS 82
DEMINERALIZED BONE MATRIX PRODUCTS 83
TABLE 19 SELECTED DBM PRODUCTS AND PERCENTAGE OF DEMINERALIZED BONE
MATRIX 84
ALLOGRAFT SUPPLIERS 84 '/>"/>

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