Navigation Links
Regenerating spinal cord fibers may be treatment for stroke-related disabilities
Date:5/23/2013

DETROIT A study by researchers at Henry Ford Hospital found "substantial evidence" that a regenerative process involving damaged nerve fibers in the spinal cord could hold the key to better functional recovery by most stroke victims.

The findings may offer new hope to those who suffer stroke, the leading cause of long-term disability in adults. Although most stroke victims recover some ability to voluntarily use their hands and other body parts, about half are left with weakness on one side of their bodies, while a substantial number are permanently disabled.

The study is published in the current issue of Stroke and is available online at http://stroke.ahajournals.org/content/early/2013/05/21/STROKEAHA.113.001162.abstract.html?ijkey=vRk14HxuNKPaw51&keytype=ref. Discovering a treatment to improve or restore this lost motor function in stroke patients is a holy grail for neurologists, because none exists, primarily due to unsolved mysteries about how the brain and nerves repair themselves.

The new Henry Ford research was intended to solve some of those mysteries. It focused on changes in axons the fibers, the nerve signal "transmission" lines within the spinal cord that affect voluntary movement after stroke.

Researchers used genetically modified mice in which the axons in the corticospinal tract, a bundle of nerves carrying signals from the brain to the spinal cord, were "stained" with fluorescent matter visible under a powerful microscope.

The researchers noted that Henry Ford's Institutional Animal Care and Use Committee approved all the experimental procedures.

The mice were trained for five days to use their left front paws to retrieve food pellets from a dispenser designed to test their dexterity. They were also given a "foot-fault test" to see how well they could walk on an unevenly spaced grid.

Next, the mice were divided into four groups. In one, the carotid arteries were blocked with a suture for one hour, much as a blood clot blocks the flow of blood to the brain in a stroke. After the suture was removed and blood flow was restored, they were given additional surgery to sever the axons of the corticospinal tract. The other groups were either given no surgery or "sham" surgery so they could be used as control groups for comparison to the first.

The single-pellet and foot-fault tests were then given three days after surgery, then weekly for 14 to 28 days to reassess dexterity, the amount of "stroke" damage to voluntary movements and the degree of recovery from the lab-induced "stroke."

"In both behavioral tests used in this study, the mice need to control the paw movement," explains Yi Li, M.D., a Henry Ford neuroscientist and lead author of the study. "Severe behavioral deficits of the left forepaw were evident in all of the mice three days after stroke.

"All animals showed significant improvement 14 days after surgery. This recovery progressed in those mice whose axons were not severed. However, in those whose axons had been eliminated, there was no significant recovery."

The researchers concluded that in the early stages after stroke, improvements in voluntary movement can be attributed to a reduction in brain swelling because of the trauma and other spontaneous repairs, while later improvements result from "neuronal plasticity" the reorganization or regeneration of nerve cells within the spinal cord in response to changes in the nerve network.

This "axonal remodeling in the spinal cord" may provide "a treatment target to develop rational therapeutic approaches to enhance neurological recovery for the mass of chronic stroke patients," says Dr. Li.

If such a treatment can be developed, it would address the single biggest concern of stroke victims, as well as those with chronic spinal cord damage.

The researchers cited a survey of such patients showing that "regaining arm and hand function is considered the highest priority for improving the quality of life."


'/>"/>

Contact: Dwight Angell
dwight.angell@hfhs.org
313-850-3471
Henry Ford Health System
Source:Eurekalert

Related medicine news :

1. Spinal Elements®, Inc. Relocates Corporate Headquarters in Carlsbad
2. Degenerative Changes Identified in Spinal Discs and Reversed With Drug Cocktail In Diabetic Mice
3. Spinal spacer procedure has fewer complications, but higher risk of repeat surgery
4. Families of SMA Awards $150,000 to Investigate New Antisense Therapies for Spinal Muscular Atrophy
5. Michigan Car Accident Attorneys at Buckfire & Buckfire, P.C. Sponsor Gala for Spinal Cord Injury Victims
6. Atlantic Spine Center Announces Updated Web Content on Spinal Stenosis New Treatments and a Better Approach to Spinal Stenosis Surgery
7. Medical Marketing Firm MCPR Introduces Spinal Cord Injury Expert for Media Interviews
8. Watson, IBM'S Supercomputer is Now Programmed to Recommend Perispinally Administered Etanercept as an Alzheimer's Disease Treatment
9. Study highlights variations in spinal component costs
10. Researchers develop new anatomically based classification for diagnosing cervical spinal stenosis
11. Breakthrough Drug MW151 Emerges as a Potential Competitor to Perispinally Administered Etanercept Inducing Rapid Recovery of Functions Lost to Alzheimer’s, Stroke and TBI
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2017)... Boca Raton, FL (PRWEB) , ... January 21, 2017 , ... ... from Germany, announced it is bringing its product to the United States as part ... perfected over the last 25 years, Alcovit aims to reduce the productions of nasty ...
(Date:1/21/2017)... , ... January 21, 2017 , ... ... Alumni Relations, Dianne Travis-Teague, the electrifying line-up of events for its annual meeting ... family, friends, and community. “Coming Home 2017” will be held on Friday ...
(Date:1/21/2017)... ... 21, 2017 , ... The Nobel Biocare™ dental implant company ... for its creos™ line of bone regenerative products. Specifically, the Nobel ... utilizes creos™ allo.gain™ bone graft for a variety of bone reconstruction procedures. In ...
(Date:1/20/2017)... ... January 20, 2017 , ... Source Vitál Apothecary, a skin and body ... oils, announced the company had a successful visit to the 2017 ECRM Diet, Vitamin ... companies that work in the nutritional, sports and health industries a chance to meet ...
(Date:1/20/2017)... ... January 20, 2017 , ... ATP Science, an Australian-based ... recently attended the January ECRM Trade Show in Hilton Head, SC, benefiting from ... large range of supplements that keep the body functioning at its peak performance ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... Incretin Mimetics/GLP-1 Agonists, SNDRIs, Lipase Inhibitors, Serotonin Receptor Agonists, Sympathomimetic-GABA ... drugs market is expected to grow at a CAGR of ... of 38.7% in the second half of the forecast period. The ... 2016 to 2027. The market is estimated at $1,058 million in ... ...
(Date:1/19/2017)... James Gilbart , ... 2016;12(Suppl 2):3-8; http://www.touchoncology.com/articles/optimising-clinical-outcomes-gastrointestinal-cancers-through-inhibiting-angiogenesis-and ... ... recently in a supplement to European Oncology & ... article by James Gilbart and ...
(Date:1/19/2017)... PALO ALTO, Calif. , Jan. 19, 2017 /PRNewswire/ ... scientific research, is excited to announce that the ... Project: Cancer Biology  (RP:CB) have been published in ... science, this project represents the first practical evaluation ... that result in reproducible studies. Unlike other assessments ...
Breaking Medicine Technology: