Navigation Links
Regenerating spinal cord fibers may be treatment for stroke-related disabilities
Date:5/23/2013

DETROIT A study by researchers at Henry Ford Hospital found "substantial evidence" that a regenerative process involving damaged nerve fibers in the spinal cord could hold the key to better functional recovery by most stroke victims.

The findings may offer new hope to those who suffer stroke, the leading cause of long-term disability in adults. Although most stroke victims recover some ability to voluntarily use their hands and other body parts, about half are left with weakness on one side of their bodies, while a substantial number are permanently disabled.

The study is published in the current issue of Stroke and is available online at http://stroke.ahajournals.org/content/early/2013/05/21/STROKEAHA.113.001162.abstract.html?ijkey=vRk14HxuNKPaw51&keytype=ref. Discovering a treatment to improve or restore this lost motor function in stroke patients is a holy grail for neurologists, because none exists, primarily due to unsolved mysteries about how the brain and nerves repair themselves.

The new Henry Ford research was intended to solve some of those mysteries. It focused on changes in axons the fibers, the nerve signal "transmission" lines within the spinal cord that affect voluntary movement after stroke.

Researchers used genetically modified mice in which the axons in the corticospinal tract, a bundle of nerves carrying signals from the brain to the spinal cord, were "stained" with fluorescent matter visible under a powerful microscope.

The researchers noted that Henry Ford's Institutional Animal Care and Use Committee approved all the experimental procedures.

The mice were trained for five days to use their left front paws to retrieve food pellets from a dispenser designed to test their dexterity. They were also given a "foot-fault test" to see how well they could walk on an unevenly spaced grid.

Next, the mice were divided into four groups. In one, the carotid arteries were blocked with a suture for one hour, much as a blood clot blocks the flow of blood to the brain in a stroke. After the suture was removed and blood flow was restored, they were given additional surgery to sever the axons of the corticospinal tract. The other groups were either given no surgery or "sham" surgery so they could be used as control groups for comparison to the first.

The single-pellet and foot-fault tests were then given three days after surgery, then weekly for 14 to 28 days to reassess dexterity, the amount of "stroke" damage to voluntary movements and the degree of recovery from the lab-induced "stroke."

"In both behavioral tests used in this study, the mice need to control the paw movement," explains Yi Li, M.D., a Henry Ford neuroscientist and lead author of the study. "Severe behavioral deficits of the left forepaw were evident in all of the mice three days after stroke.

"All animals showed significant improvement 14 days after surgery. This recovery progressed in those mice whose axons were not severed. However, in those whose axons had been eliminated, there was no significant recovery."

The researchers concluded that in the early stages after stroke, improvements in voluntary movement can be attributed to a reduction in brain swelling because of the trauma and other spontaneous repairs, while later improvements result from "neuronal plasticity" the reorganization or regeneration of nerve cells within the spinal cord in response to changes in the nerve network.

This "axonal remodeling in the spinal cord" may provide "a treatment target to develop rational therapeutic approaches to enhance neurological recovery for the mass of chronic stroke patients," says Dr. Li.

If such a treatment can be developed, it would address the single biggest concern of stroke victims, as well as those with chronic spinal cord damage.

The researchers cited a survey of such patients showing that "regaining arm and hand function is considered the highest priority for improving the quality of life."


'/>"/>

Contact: Dwight Angell
dwight.angell@hfhs.org
313-850-3471
Henry Ford Health System
Source:Eurekalert

Related medicine news :

1. Spinal Elements®, Inc. Relocates Corporate Headquarters in Carlsbad
2. Degenerative Changes Identified in Spinal Discs and Reversed With Drug Cocktail In Diabetic Mice
3. Spinal spacer procedure has fewer complications, but higher risk of repeat surgery
4. Families of SMA Awards $150,000 to Investigate New Antisense Therapies for Spinal Muscular Atrophy
5. Michigan Car Accident Attorneys at Buckfire & Buckfire, P.C. Sponsor Gala for Spinal Cord Injury Victims
6. Atlantic Spine Center Announces Updated Web Content on Spinal Stenosis New Treatments and a Better Approach to Spinal Stenosis Surgery
7. Medical Marketing Firm MCPR Introduces Spinal Cord Injury Expert for Media Interviews
8. Watson, IBM'S Supercomputer is Now Programmed to Recommend Perispinally Administered Etanercept as an Alzheimer's Disease Treatment
9. Study highlights variations in spinal component costs
10. Researchers develop new anatomically based classification for diagnosing cervical spinal stenosis
11. Breakthrough Drug MW151 Emerges as a Potential Competitor to Perispinally Administered Etanercept Inducing Rapid Recovery of Functions Lost to Alzheimer’s, Stroke and TBI
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/6/2016)... ... February 06, 2016 , ... Research has shown that building ... the frequency and level of relapse. , At the 2016 iaedp ... will explore the critical tasks of the recovery phase and beyond including relapse ...
(Date:2/5/2016)... , ... February 05, 2016 , ... Love is in ... in a variety of colors, assortments and packaging. This staple for Valentine’s Day is ... Kullen location. , For Valentine’s Day, not only are long-stem roses available, but ...
(Date:2/5/2016)... City, UT (PRWEB) , ... February 05, 2016 , ... ... Whole-Food Nutrition , announced that the much-anticipated feature with author Jahnavi Foster, specialist in ... Humans Amateur TV Network. , Each week, on his weekly Whole-Food Warrior TV show, ...
(Date:2/5/2016)... ... February 05, 2016 , ... The event is being held ... Event Center in Minneapolis, Minn. Triumph Over Parkinson’s will fund nearly $100,000 for research ... Schneiderman’s Furniture, lives with Parkinson’s disease and is the architect of this informative event ...
(Date:2/5/2016)... ... February 05, 2016 , ... Francisco Canales, ... services in their Napa Valley office. The technique utilizes the body’s own healing ... Canales and Dr. Furnas, are part of only a select few cosmetic surgeons ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... LONDON , Feb. 4, 2016 ... Summary Global Markets Direct,s, ,Wegener Polyangiitis - ... the Wegener Polyangiitis,s therapeutic pipeline. This report ... Wegener Polyangiitis, complete with comparative analysis at various ... action (MoA), route of administration (RoA) and molecule ...
(Date:2/4/2016)... LONDON , Feb. 4, 2016 ... and competitive market to drive long-term market growth ... very common set of chronic disorders that affect ... disparate in terms of their symptoms and key ... by dysregulation of immune pathways and an inappropriate ...
(Date:2/4/2016)... COLUMBUS, Ohio, Feb. 4, 2016 Mettler-Toledo International ... results for 2015.  Provided below are the highlights: ... the quarter compared with the prior year.  Reported sales ... in the quarter. , Net earnings per diluted ... in the prior- year period.  Adjusted EPS was $4.65, ...
Breaking Medicine Technology: