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Regenerating our kidneys
Date:6/16/2014

kers allowed researchers to trace cell growth in vivo growth, they were surprised to find, that was sectional and multi-directional.

"We were amazed to find that renal growth does not depend on a single stem cell, but is rather compartmentalized," said Dr. Dekel.

"Each part of the nephron is responsible for its own growth, each segment responsible for its own development, like a tree trunk and branches each branch grows at a different pace and in a different direction."

Using the rainbow mouse, the researchers were able to pinpoint a specific molecule responsible for renal cellular growth called the "WNT signal". Once activated in specific precursor cells in each kidney segment, the WNT signal results in robust renal cellular growth and generation of long branches of cells.

"Our aim was to use a new technique to analyze an old problem," said Dr. Dekel. "No one had ever used a rainbow mouse model to monitor development of kidney cells. It was exciting to use these genetic tricks to discover that cellular growth was occurring all the time in the kidney that, in fact, the kidney was constantly remodelling itself in a very specific mode."

Dr. Dekel and the research team are paving the way for novel cellular and molecular therapeutics to achieve human kidney regeneration and alleviate shortage of kidney organs for transplantation. "This study teaches us that in order to regenerate the entire kidney segments different precursor cells grown outside of our bodies will have to be employed," he said. "In addition, If we were able to further activate the WNT pathway, then in cases of disease or trauma we could activate the phenomena for growth and really boost kidney regeneration to help patients. This is a platform for the development of new therapeutics, allowing us to follow the growth and expansion of cells following treatment."


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Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Page: 1 2

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