Navigation Links
Regenerating our kidneys
Date:6/16/2014

Doctors and scientists have for years been astonished to observe patients with kidney disease experiencing renal regeneration. The kidney, unlike its neighbor the liver, was universally understood to be a static organ once it had fully developed.

Now a new study conducted by researchers at Sheba Medical Center, Tel Aviv University and Stanford University turns that theory on its head by pinpointing the precise cellular signalling responsible for renal regeneration and exposing the multi-layered nature of kidney growth. The research, in Cell Reports, was conducted by principal investigators Dr. Benjamin Dekel of TAU's Sackler School of Medicine and Sheba Medical Center and Dr. Irving L. Weissman of Stanford University's School of Medicine, working with teams of researchers from both universities.

"We wanted to change the way people thought about kidneys about internal organs altogether," said Dr. Dekel, who specializes in stem-cell research, genetics, and nephrology. "Very little is known even now about the way our internal organs function at the single cell level. This study flips the paradigm that kidney cells are static in fact, kidney cells are continuously growing, all the time."

Dr. Dekel began researching the subject three years ago while on sabbatical at Stanford University. While the laboratory experiments and stem cell research were conducted at Stanford, the results were analyzed by researchers at TAU and Stanford.

According to Dr. Dekel, scientists knew kidney cells could reproduce outside the body, but the physiological process taking place inside the body at the single cell level was never explored. Uncovering that process became the focus of his efforts.

Dr. Dekel and his research team conducted a study using a "rainbow mouse" model developed at Stanford's Weissman lab, a mouse genetically altered to express one of four alternative fluorescent markers called "reporters" in each cell. The markers allowed researchers to trace cell growth in vivo growth, they were surprised to find, that was sectional and multi-directional.

"We were amazed to find that renal growth does not depend on a single stem cell, but is rather compartmentalized," said Dr. Dekel.

"Each part of the nephron is responsible for its own growth, each segment responsible for its own development, like a tree trunk and branches each branch grows at a different pace and in a different direction."

Using the rainbow mouse, the researchers were able to pinpoint a specific molecule responsible for renal cellular growth called the "WNT signal". Once activated in specific precursor cells in each kidney segment, the WNT signal results in robust renal cellular growth and generation of long branches of cells.

"Our aim was to use a new technique to analyze an old problem," said Dr. Dekel. "No one had ever used a rainbow mouse model to monitor development of kidney cells. It was exciting to use these genetic tricks to discover that cellular growth was occurring all the time in the kidney that, in fact, the kidney was constantly remodelling itself in a very specific mode."

Dr. Dekel and the research team are paving the way for novel cellular and molecular therapeutics to achieve human kidney regeneration and alleviate shortage of kidney organs for transplantation. "This study teaches us that in order to regenerate the entire kidney segments different precursor cells grown outside of our bodies will have to be employed," he said. "In addition, If we were able to further activate the WNT pathway, then in cases of disease or trauma we could activate the phenomena for growth and really boost kidney regeneration to help patients. This is a platform for the development of new therapeutics, allowing us to follow the growth and expansion of cells following treatment."


'/>"/>
Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Related medicine news :

1. Regenerating spinal cord fibers may be treatment for stroke-related disabilities
2. Blocking signal-transmitting cellular pores may prevent damage to kidneys
3. Urine biomarker test can diagnose as well as predict rejection of transplanted kidneys
4. Study suggests new source of kidneys for transplant
5. Kidneys Sometimes Removed Needlessly in Patients With Rare Genetic Disorder
6. Treating Kidneys With Radio Waves May Ease Tough-to-Control Hypertension
7. Tight Blood-Sugar Control Shows Mixed Results for Health of Kidneys: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... ... TopConsumerReviews.com recently awarded their highest five-star rating to Best Buy Eyeglasses, an ... United States and Canada wear eyeglasses. Once considered to be a purely functional part ... fashion statement. Even celebrities use glasses as a way of creating an iconic image—like ...
(Date:6/26/2016)... ... , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect ... a whole new perspective by using the title layers in ProSlice Levels to ... ProSlice Levels contains over 30 Different presets to choose from. FCPX users ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... ... ... temporary closing of Bruton Memorial Library on June 21 due to a possible lice infestation, ... aspect of head lice: the parasite’s ability to live away from a human host, and ... necessary one in the event that lice have simply gotten out of control. , As ...
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... a startling report released today, National Safety Council research ... proven plan to eliminate prescription opioid overdoses. Prescription Nation ... tackling the worst drug crisis in recorded U.S. history, assigned a ... , New Mexico , Tennessee ... failing states, three – Michigan , ...
(Date:6/23/2016)... Research and Markets has announced the ... 2016 - Forecast to 2022" report to their offering. ... up to date financial data derived from varied research sources ... with potential impact on the market during the next five ... comprises of sub markets, regional and country level analysis. The ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Issue 52" report to their offering. ... treatment creates a favourable commercial environment for MedImmune to enter. ... base that will serve to drive considerable growth for effective ... serve to cap sales considerably, but development is still in ...
Breaking Medicine Technology: