Navigation Links
Reflux esophagitis due to immune reaction, not acute acid burn
Date:11/19/2009

DALLAS Nov. 19, 2009 Contrary to current thinking, a condition called gastroesophageal reflux disease (GERD) might not develop as a direct result of acidic digestive juices burning the esophagus, UT Southwestern Medical Center researchers have found in an animal study.

Rather, gastroesophageal reflux spurs the esophageal cells to release chemicals called cytokines, which attract inflammatory cells to the esophagus. It is those inflammatory cells, drawn to the esophagus by cytokines, that cause the esophageal damage that is characteristic of GERD. The condition is manifested by symptoms such as heartburn and chest pain.

"Currently, we treat GERD by giving medications to prevent the stomach from making acid," said Dr. Rhonda Souza, associate professor of internal medicine at UT Southwestern and lead author of the study appearing the November issue of Gastroenterology. "But if GERD is really an immune-mediated injury, maybe we should create medications that would prevent these cytokines from attracting inflammatory cells to the esophagus and starting the injury in the first place."

In the study, researchers created GERD in rats by connecting the duodenum to the esophagus. This operation allows stomach acid and bile to enter the esophagus. Researchers were surprised to learn that esophagitis didn't develop for a number of weeks after the operation.

"That doesn't make sense if GERD is really the result of an acid burn, as we all were taught in medical school," said Dr. Stuart Spechler, professor of internal medicine at UT Southwestern and senior author of the study. "Chemical injuries develop immediately. If you spill battery acid on your hand, you don't have to wait a month to see the damage."

About 40 percent of Americans suffer symptoms of GERD at some point, and 20 percent on a weekly basis, Dr. Souza said. Over the long term, GERD could eventually lead to esophageal cancer.

Previous studies had sh
'/>"/>

Contact: LaKisha Ladson
lakisha.ladson@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
2. The First Incisionless Transoral Fundoplication for Treatment of Gastroesophageal Reflux is Performed in the U.S. at Ohio State University and Oregon Health & Science University Medical Centers
3. Reflux Can Precipitate Chest Pain, Cough
4. Chronic Reflux Often Leads to Sleepless Nights
5. Anti-Reflux Drugs May Be Overprescribed in Infants
6. No link between acid reflux and survival
7. Scientists identify how gastric reflux may trigger asthma
8. Revolutionary Procedure for the Treatment of Gastroesophageal Reflux Now Possible in San Francisco Thanks to Dr. Paul Cirangle
9. Study compares 2 nonsurgical treatments for reflux disease
10. Is esomeprazole the best choice for reflux esophagitis patients?
11. Acid Reflux No More With Amish Formula From Caleb Treeze Organic Farm
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Reflux esophagitis due to immune reaction, not acute acid burn
(Date:5/20/2013)... 2013 On May 14th, premiere Atlanta ... about how one of its patients originally came to ... being diagnosed with giant papillary conjunctivitis. “Giant papillary conjunctivitis ... eye, and for one of our patients in particular, ... says the Medical Director of the Atlanta Vision Institute ...
(Date:5/20/2013)... 20, 2013 iGearUnlimited.com asked schools' technology directors ... for students. The answers didn't surprise anyone: , 1. A ... and abuse, 2. Not too bulky – need to fit ... Built-in kick-stand that works in both vertical and horizontal orientations, ... trackable barcodes on each case, 5. Customizable – schools love ...
(Date:5/20/2013)... May 20, 2013 Widely regarded as ... genital plastic surgery and women’s sexual health, Dr. Goodman ... Board of http://www.labiaplastysurgeon.com , the nationally ranked ... proud to be a member of this informative and ... the appointment. “I’ve already worked with the President ...
(Date:5/20/2013)... (PRWEB) May 20, 2013 Milpitas, ... an industry leader in enterprise-class information archiving, eDiscovery ... eDiscovery Platform 7.0, the latest release in the ... facets of the legal discovery lifecycle. MessageSolution will ... Los Angeles CA. , As the first stop ...
(Date:5/20/2013)... AURORA, Colo. (PRWEB) May 20, 2013 ... University, a leading online accredited university, has developed a ... to help nurses assess how they feel about continuing ... BSN. Nurses can print out the complimentary worksheet, respond ... to see how they rate on a BSN-readiness scale. ...
Breaking Medicine News(10 mins):Health News:Atlanta LASIK Practice Publishes a Patient’s Testimonial About Allergy to Contact Lenses 2Health News:New Rugged iPad Case for Bretford Charging Cart Saves the Day for School Deployments 2Health News:New Rugged iPad Case for Bretford Charging Cart Saves the Day for School Deployments 3Health News:Globally Respected Feminine Cosmetic Genital Surgeon Joins Board of Industry Leading Labiaplasty Medical Website 2Health News:Globally Respected Feminine Cosmetic Genital Surgeon Joins Board of Industry Leading Labiaplasty Medical Website 3Health News:MessageSolution Releases Enterprise eDiscovery Platform 7.0 at LegalTech 2013 West Coast Expo 2Health News:MessageSolution Releases Enterprise eDiscovery Platform 7.0 at LegalTech 2013 West Coast Expo 3Health News:MessageSolution Releases Enterprise eDiscovery Platform 7.0 at LegalTech 2013 West Coast Expo 4Health News:American Sentinel University Develops New Worksheet to Help Nurses Determine BSN-Readiness 2Health News:American Sentinel University Develops New Worksheet to Help Nurses Determine BSN-Readiness 3
... the sea-bed for abalone are paying with their lives. Four ... abalone, which is used in sushi// and a variety of ... on the black market. ,Abalone are a special ... is considered a delicacy in certain parts of Latin America ...
... of water to keep oneself cool may not be a ... warns scientists for marathon runners//. ,With today's temperatures ... lose almost a litre of sweat every hour and reach ... normal. The sporting community has long assumed that drinking large ...
... Parkinson's sufferers are usually treated with the drug called ... After prolonged use of the drug, many patients may ... drug. ,Parkinson's disease is a slow process ... dopamine levels fall, the symptoms of Parkinson’s shows up ...
... the possible reasons for them, a survey was conducted ... that present statistics of stillborns remained unchanged upon comparison ... in 200 pregnancies resulted in stillbirth, the survey showed. ... (CEMACH) revealed that there were 3,600 stillbirths ...
... to eat more by seeing the food ads on television, ... children// are more vulnerable to it. ,Researchers ... on Obesity in Budapest, said they exposed a group of ... series of food and toy adverts on television, followed by ...
... planning to build the world's first "green" skyscraper that ... part of the// emirate's efforts to remain an international ... skyscraper will feature revolving floors with the entire building ... will make it independent of outside energy sources, according ...
Cached Medicine News:Health News:Hunt for Sea Delicacy Taking a Toll in California 2Health News:Hunt for Sea Delicacy Taking a Toll in California 3Health News:Large Fluid Intake Won’t Help to Keep Cool for Marathon Runner 2Health News:Stillbirth Figures Stand Still 2Health News:Food Ads Prompts Children to Eat More 2
(Date:5/17/2013)...  Sorrento Therapeutics, Inc. (OTCBB: SRNE; or STI) ... Business Technology Transfer Research (STTR) grant (#1R42AI098182-02) from ... (NIAID), a division of the National Institutes of ... antibody therapeutics to combat Staphylococcus aureus ... methicillin-resistant S. aureus (MRSA), was renewed ...
(Date:5/17/2013)... 17, 2013   Shareholder rights attorneys  at Robbins ... Inc. (NASDAQGS: AVEO) securities has filed a complaint in ... Massachusetts .  The complaint alleges that Aveo ... Act of 1934 (the "Exchange Act") between January 3, ... (Logo: http://photos.prnewswire.com/prnh/20130103/MM36754LOGO ) ...
(Date:5/17/2013)... YORK , May 17, 2013 /PRNewswire-iReach/ -- United ... Advanced Cardiac Life Support (ACLS), Pediatric Advanced Life Support ... free PALS, BLS and ACLS online course ... manuals, people simply need to build an account with ... materials for these programs, United Medical Education is setting ...
Breaking Medicine Technology:Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 2Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 3Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 4Aveo Pharmaceuticals, Inc. Sued by Investor 2Aveo Pharmaceuticals, Inc. Sued by Investor 3ACLS Online Course Manuals are Now Available at No Cost through United Medical Education 2
... Trial Demonstrates Increased Dermal Penetration of TPM/Lidocaine Compared to ... MELBOURNE, Australia, Dec. 8 Phosphagenics Limited ("Phosphagenics") (ASX: ... a phase 1 clinical trial that examined the ability ... deliver the pain relief drug, lidocaine, safely into humans. ...
... SUPG ), a pharmaceutical company dedicated to the discovery ... PIM kinase inhibitor, SGI-1776, is effective both in vitro and in ... . This research was presented at the 50th Annual ... , In a poster presentation entitled " ...
Cached Medicine Technology:Positive Phase 1 Clinical Trial Results for Transdermal Lidocaine 2Positive Phase 1 Clinical Trial Results for Transdermal Lidocaine 3SuperGen's PIM Kinase Inhibitor, SGI-1776, Effective in Pre-Clinical Models of Acute Lymphoblastic Leukemia 2SuperGen's PIM Kinase Inhibitor, SGI-1776, Effective in Pre-Clinical Models of Acute Lymphoblastic Leukemia 3
... Class II Direct to High Res SSP kits provide ... single tray. Locus specific typing on a single tray ... Straight from genomic DNA to high resolution results, ... level typing with a single tray , Unique reaction ...
... Res SSP kits provide high resolution typing of the ... on a single tray reduces QC and testing costs ... to high resolution results, no need for initial low ... tray , Unique reaction pattern for most common alleles ...
... utilizes allele-specific primer combinations in the PCR ... that only primers whose sequence is completely ... converted by the polymerase into PCR products. ... product. Using the Biotest SSP Kit Systems, ...
... freezer is constructed with built-in bags as in ... bags are placed without contacting the ethylene glycol ... inserts. This device ensures easy handling and maximum ... bags so that the relatively hot air under ...
Medicine Products: