Navigation Links
Reflux esophagitis due to immune reaction, not acute acid burn
Date:11/19/2009

DALLAS Nov. 19, 2009 Contrary to current thinking, a condition called gastroesophageal reflux disease (GERD) might not develop as a direct result of acidic digestive juices burning the esophagus, UT Southwestern Medical Center researchers have found in an animal study.

Rather, gastroesophageal reflux spurs the esophageal cells to release chemicals called cytokines, which attract inflammatory cells to the esophagus. It is those inflammatory cells, drawn to the esophagus by cytokines, that cause the esophageal damage that is characteristic of GERD. The condition is manifested by symptoms such as heartburn and chest pain.

"Currently, we treat GERD by giving medications to prevent the stomach from making acid," said Dr. Rhonda Souza, associate professor of internal medicine at UT Southwestern and lead author of the study appearing the November issue of Gastroenterology. "But if GERD is really an immune-mediated injury, maybe we should create medications that would prevent these cytokines from attracting inflammatory cells to the esophagus and starting the injury in the first place."

In the study, researchers created GERD in rats by connecting the duodenum to the esophagus. This operation allows stomach acid and bile to enter the esophagus. Researchers were surprised to learn that esophagitis didn't develop for a number of weeks after the operation.

"That doesn't make sense if GERD is really the result of an acid burn, as we all were taught in medical school," said Dr. Stuart Spechler, professor of internal medicine at UT Southwestern and senior author of the study. "Chemical injuries develop immediately. If you spill battery acid on your hand, you don't have to wait a month to see the damage."

About 40 percent of Americans suffer symptoms of GERD at some point, and 20 percent on a weekly basis, Dr. Souza said. Over the long term, GERD could eventually lead to esophageal cancer.

Previous studies had sh
'/>"/>

Contact: LaKisha Ladson
lakisha.ladson@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
2. The First Incisionless Transoral Fundoplication for Treatment of Gastroesophageal Reflux is Performed in the U.S. at Ohio State University and Oregon Health & Science University Medical Centers
3. Reflux Can Precipitate Chest Pain, Cough
4. Chronic Reflux Often Leads to Sleepless Nights
5. Anti-Reflux Drugs May Be Overprescribed in Infants
6. No link between acid reflux and survival
7. Scientists identify how gastric reflux may trigger asthma
8. Revolutionary Procedure for the Treatment of Gastroesophageal Reflux Now Possible in San Francisco Thanks to Dr. Paul Cirangle
9. Study compares 2 nonsurgical treatments for reflux disease
10. Is esomeprazole the best choice for reflux esophagitis patients?
11. Acid Reflux No More With Amish Formula From Caleb Treeze Organic Farm
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Reflux esophagitis due to immune reaction, not acute acid burn
(Date:12/20/2014)... OH (PRWEB) December 20, 2014 ... contend they suffered uncontrollable bleeding and other serious ... Court, Eastern District of Louisiana for coordinated pretrial proceedings, ... on Multidistrict Litigation (JPML) issued an order Friday to ... actions pending in 22 federal courts to the Louisiana ...
(Date:12/19/2014)... It’s very easy to become overwhelmed with the holidays ... the wayside until Christmas and the New Year are over. ... that burning desire to just escape it all and get ... Telluride with a no-fuss, affordable package. Montrose Days Inn will ... and ensure that all accommodations are met. Plus, everyone has ...
(Date:12/19/2014)... Silver Dollar City is picking up ... the first time ever, Silver Dollar City has a title ... 2015, listing the park’s wood coaster Outlaw Run as the ... announced this week, Silver Dollar City is named in CNN ... USA Today’s 10Best awards for “Best Public Lights Display,” and ...
(Date:12/19/2014)... The Medspa at Hendrick in Abilene, ... respected cosmetic brand Juvéderm. Voluma XC treats volume loss ... Medspa at Hendrick is pleased to be able to ... to its clients. , Voluma is the first and ... treat the mid-face and cheek area. This non-invasive treatment ...
(Date:12/19/2014)... 19, 2014 (HealthDay News) -- Potentially illness-causing E. coli ... at farmers markets, according to a new study. ... vendors from 13 farmers markets in Los Angeles and ... Out of almost 150 samples tested, 24 percent were ... salmonella, according to the researchers. Both types of ...
Breaking Medicine News(10 mins):Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 2Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 3Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 4Health News:Days Inn Montrose Colorado Delivers Last Minute Holiday Season Ski Getaway Accommodations 2Health News:Silver Dollar City Nets New Titles: Guinness Book of World Records, Plus CNN Travel, USA Today & Fodor’s Top Places for Christmas Lights 2Health News:Breakthrough New Injectable Dermal Filler Voluma XC Offered by The MedSpa at Hendrick 2Health News:E. Coli Germs Found on Farmers Market Herbs 2
... 28, 2008) Scientists at NanoBio Corporation have demonstrated ... topical treatment for cold sores (herpes labialis), NB-001, speeds ... systemic drugs but without safety or toxicity concerns. , ... that a topical agent can attain equivalent efficacy rates ...
... WASHINGTON, Oct. 28 In recognition of,Veterans Day, ... with the Prostate Cancer Education Council, and the,American ... and,education event in the Redskins players, locker room ... to be proactive about their,health., The event ...
... Did you know that one in six men ... prostate cancer occurs,every 2.5 minutes and a man dies ... men,s health first., Listen to this report from ... access video, audio, text, graphics and,photos for free and ...
... propofol tied to cardiac arrest in patients with a ... Use of the sedative propofol is associated with a high ... seizures, according to a study by researchers at the Mayo ... with refractory status epilepticus (RSE) -- prolonged seizures that don,t ...
... common, potentially lethal disease, survey shows , , TUESDAY, Oct. 28 ... for developing diabetes, too few perceive the threat it can ... In fact, most respondents feared shark bites, plane crashes or ... diabetes, according to the pollsters. , "We undertook the survey ...
... PHILADELPHIA, Oct. 28 The Family Planning,Council was recently ... Human Services for a total of $3 million. These ... areas: the,use of Natural Family Planning as a method ... women; and, creating a model program to,provide family planning ...
Cached Medicine News:Health News:Topical treatment for cold sores achieves efficacy of oral drugs; represents paradigm shift 2Health News:Washington Redskins Open FedExField Locker Room to ALL Military Veterans for Free Health Screenings 2Health News:Sedative Could Be Deadly in People With Seizures 2Health News:Too Few Understand Diabetes' Dangers 2Health News:Too Few Understand Diabetes' Dangers 3Health News:Local Organization Receives Multi-Million Dollar Grants for Natural Family Planning, HIV Testing and Family Planning Services for Men 2
(Date:12/19/2014)... Dec. 19, 2014 In today,s rapidly ... marketing communication tools are essential for survival. The ... consequently consumers, desires, preferences, and unmet needs are ... research groups across all industries are continually searching ... However, the adoption of new market research techniques ...
(Date:12/19/2014)... Dec. 18, 2014 Research and Markets ... of the "Micro Market Monitor: North American ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... progressing steadily, which has resulted in fueling the ... The main purpose of these dermatology devices is ...
(Date:12/19/2014)... -- Baptist Health Lexington is the first facility in ... Fibrillation with Electrophysiology Services (EPS) Accreditation status from the Society ... the most common cardiac arrhythmia and has become recognized as ... stroke and possible death. More than 5 million patients in ... and the numbers are rapidly increasing as the population ages. ...
Breaking Medicine Technology:Study Uncovers New Tools and Techniques for Understanding Consumer Decision Making 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 3Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3
... , , , ... a worldwide leader in biotechnology services, has appointed Richard Jennings ... division. Brought in as a consultant with FamilyCord in ... and vision. As President, Jennings will assume responsibility for all ...
... , , , SEATTLE, Aug. ... people who eat mindfully are less likely to be obese, according ... Center. , , The study was prompted by ... colleagues, who found that regular yoga practice may help prevent middle-age ...
Cached Medicine Technology:California Cryobank Names Richard Jennings President of FamilyCord Division 2Regular Yoga Practice Is Associated With Mindful Eating 2Regular Yoga Practice Is Associated With Mindful Eating 3Regular Yoga Practice Is Associated With Mindful Eating 4
Malis CMC-III Generator provides both coagulation and cutting outputs....
...
...
...
Medicine Products: