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Reduction in glycotoxins from heat-processing of foods reduces risk of chronic disease
Date:11/3/2009

n foods are heated, pasteurized, dried, smoked, fried or grilled. Once absorbed in the body, AGEs adhere to tissues and oxidize them, causing inflammation which in turn can lead to disease. Numerous animal studies conducted by Dr. Vlassara and her team have shown that oxidative stress from high oxidant levels and inflammation related to long-term exposure to AGEs may increase the risk of diabetes, heart disease, kidney disease and other chronic conditions.

For the study, a subset of 40 healthy participants who were either between the ages or 18 and 45 or older than 60, and another nine patients with kidney disease, were randomly assigned to one of two diets. One group followed their own regular Western diet that was rich in AGEs. The second group followed a diet of similar caloric and nutrient content, but with only one-half the amount of AGEs, known as the "AGE-less diet." Participants in the AGE-less intervention were advised to avoid grilling, frying or baking their food and instead were instructed to poach, stew, or steam their meals. There was no change in calories or nutrient intake during this period.

After four months on the AGE-less diet, blood AGE levels, lipid peroxides, inflammatory markers, and biomarkers of vascular function declined by as much as 60 percent in healthy participants. A reduction of similar magnitude was found in kidney patients after only one month on the AGE-less diet.

Researchers also found a positive effect on a cellular receptor for AGEs called AGER1, which is critical for the clearance of toxic AGEs from the body. The number of copies of the AGER1 gene was measured in circulating blood cells. Since this number was severely suppressed in participants with kidney disease, all of whom had very high levels of AGEs, the researchers speculate that important defense mechanisms can become "exhausted" as a result of chronically elevated AGEs. However, after a short period on the AGE-reduced diet, the number of A
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