Navigation Links
Reduction in antibody gene rearrangement in B cells related to type 1 diabetes, lupus
Date:12/23/2008

ains Prak. "Editing errors develop before B cells leave the bone marrow. However, treatments such as B-cell depletion might be less likely to work in patients with editing errors because the self-attacking B cells can be regenerated rapidly as they develop in the bone marrow."

The researchers found a way to look at the editing history of B cells in the human and mouse samples, by monitoring the frequency of a non-functional light chain genetic rearrangement in the B cell antibody, which is termed RS. The investigators surmise that a decrease in RS levels indicates that B cells that react with self can evade editing of their self-reactivity and that defects in editing, in turn, may lead to an increased risk of developing autoimmune disease.

The measurement of RS frequency is independent of antibody specificity and, because it is non-functional and irreversible, it can be used to monitor the level of antibody gene rearrangement in any B cell population and in any autoimmune disease. The team is now interested in testing if RS frequency is altered in other autoimmune diseases and if a low RS level in an apparently healthy person is predictive of future autoimmunity. The RS assay may also be of use to clinicians who treat patients with established autoimmunity and to researchers who are mapping genes that are associated with different underlying causes of autoimmunity.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Smaller breast reduction surgeries provide health benefits and should be reimbursed
2. ACM Helps Medicaid Programs Comply With Federal Deficit Reduction Act Mandates
3. Cancer researchers seek safe reduction of radiotherapy
4. Revisions to College Cost Reduction and Access Act will create barriers to primary care
5. UltraShape(TM) Non-Invasive Fat Reduction and Body Contouring Clinical Study Results Presented at American Society for Dermatologic Surgery Annual Meeting
6. First colonoscopy with removal of polyps linked to reduction in colon cancer death
7. Leukocyte reduction seen as significant advance in transfusion medicine
8. Growth Trend for Gerresheimer Continues Unabated - Debt Reduction
9. Stress reduction products and services that are effective and safe
10. New Report Identifies Health Disparities and Reduction Strategies
11. Photo: Beverly Hills Liposculpture Specializes in Scarless Breast Reduction Dr. Alan Bittner Reduces Female Breasts by up to 50%
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Reduction in antibody gene rearrangement in B cells related to type 1 diabetes, lupus
(Date:7/31/2014)... 2014) Women over the age of 65 face ... obesity, greater struggles against poverty and higher rates of ... the August issue of Annals of Allergy, Asthma ... College of Allergy, Asthma and Immunology (ACAAI), outlines the ... offers practical solutions to improve their care. ...
(Date:7/31/2014)... Alexandria, VA (PRWEB) July 31, 2014 ... Hilton hotel in Chicago, Illinois, the Mesothelioma Applied ... Chicago Medicine, will host a one-day regional ... members, covering a variety of topics related to ... , Some of the covered topics will include ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Leelanau Peninsula’s newest ... July 3, 2014 at 7788 East Horn Road in Lake ... Wine Trail , Aurora Cellars is the 25th winery along ... including the popular wine tour events, making its trail event ... 6-7, 2014. , Owners David and Faye Mathia opened ...
(Date:7/31/2014)... 31, 2014 United Theological Seminary will ... on Monday, September 15, with its 2014 Opening Convocation, ... 3440 Shroyer Rd., Kettering, OH. Dr. Emma J. Justes, ... Emma Toussant Chair will speak on “Unexpected Undercurrents: Responding ... teaching and research interests include pastoral care and counseling, ...
(Date:7/31/2014)... Memphis, TN (PRWEB) July 31, 2014 In ... are required for proper storage of necessary life saving ... and staff. Unfortunately there is still a high number of ... is an EMT who steals the narcotics and even replaces ... urgent relief receives none. As seen in the case in ...
Breaking Medicine News(10 mins):Health News:Female baby boomers with asthma? You may need help 2Health News:Female baby boomers with asthma? You may need help 3Health News:October Events: Regional Conference on Mesothelioma in Chicago 2Health News:October Events: Regional Conference on Mesothelioma in Chicago 3Health News:Aurora Cellars Joins the Leelanau Peninsula Wine Trail 2Health News:United Theological Seminary to Open 144th Year 2Health News:New MedixSafe Alert - Ambulances Must Have A Medical Safe, Narcotics Cabinet, or Drug Locker 2
... inheritable genes to enable people to produce more ‘perfect’ ... and on being human, warns a leading US science ... out great hope for IGM technology, which offers them ... Disease and schizophrenia on to their children.// ,However, ...
... the risk of pancreatic cancer in both sexes,while moderate ... obese individuals,says Dr. Dominique S. Michaud the head ... National Cancer Institute in Rockville, Maryland and colleagues collected ... 75 years of age, who participated in the Health ...
... popular belief, the heart can actually repair itself by growing new ... researchers in New York and Italy. Dr. Piero Anversa and colleagues ... heart muscle cells called myocytes continued to divide after a heart ... examined the hearts of 13 people who died within a few ...
... patients suffering from Angina may have some new treatment ... Angina, a common cardiovascular disorder affecting millions of people ... by blood vessels too clogged to get oxygen-rich blood ... either medication or for more serious cases, rerouting the ...
... piglets last week could significantly increase the success rate ... research has indicated that rejection of animal cells and ... to the presence of the gene alpha 1,3 galactosyl ... a sugar// to the surface of pig cells, flagging ...
... A new technique to keeping heart arteries flowing easily ... solving a major weakness of the common procedure.Doctors ... - the drug-coated stent. In testing on 30 patients ... percent effective, an accomplishment almost unheard of in medicine.// ...
Cached Medicine News:Health News:Perfect babies boon or a bane? 2Health News:Antibiotic, Gene Therapy Help Treat Angina 2Health News:Antibiotic, Gene Therapy Help Treat Angina 3Health News:Xenotransplantation “breakthrough” 2Health News:A ray of hope in Angioplasty dilemma 2
(Date:7/31/2014)... (Nasdaq: NKTR ) today reported its financial results ... Cash and investments in marketable securities at June 30, ... March 31, 2014."The second half of 2014 will be an ... milestones for a number of our late-stage clinical programs," said ... "The first of these is the potential US and EU ...
(Date:7/31/2014)...  UBM Medica US announces that Cancer ... presents exclusive slide shows dealing with communication in the ... care. Cancer Network, the online ... blogs, and podcasts about the latest clinical findings. Among ... , End-of-life care is challenging for even the ...
(Date:7/31/2014)... July 31, 2014  Decision Resources Group is launching ... product Marketrack to now include ChinaTrack; the new capabilities ... in an interactive dashboard providing detailed brand-level share tracking ... a hospital level. Other key capabilities of ... feed: In addition to end-user surveys of healthcare facilities, ...
Breaking Medicine Technology:Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 2Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 3Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 4Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 5Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 6Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 7Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 8Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 9Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 10Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 11Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 12Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 13Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 14Cancer Network Highlights Methods Oncologists Can Use to Improve Communication 2Cancer Network Highlights Methods Oncologists Can Use to Improve Communication 3Decision Resources Group Announces First Medical Device Account Targeting Tool in China 2
... 2011 Johnson & Johnson (NYSE: JNJ ) ... Swiss Exchange: CRX) today announced that following the end of ... Johnson & Johnson has acquired 98.89% of the issued Shares ... Crucell) and 98.93% of the issued and outstanding Shares in ...
... Cellceutix Corporation (Pink Sheets: CTIX ) today ... Agreement (CDA) pertaining to its anti-cancer drug, Kevetrin™, with ... Cellceutix CEO, Leo Ehrlich, commented, "It,s relatively uncommon ... a compound before clinical trials are underway.  The process ...
Cached Medicine Technology:Johnson & Johnson Acquires 98.89% of Issued Crucell Shares as of the End of the Subsequent Offering Period and Crucell Intends to Delist Crucell Ordinary Shares and ADSs 2Johnson & Johnson Acquires 98.89% of Issued Crucell Shares as of the End of the Subsequent Offering Period and Crucell Intends to Delist Crucell Ordinary Shares and ADSs 3Johnson & Johnson Acquires 98.89% of Issued Crucell Shares as of the End of the Subsequent Offering Period and Crucell Intends to Delist Crucell Ordinary Shares and ADSs 4Johnson & Johnson Acquires 98.89% of Issued Crucell Shares as of the End of the Subsequent Offering Period and Crucell Intends to Delist Crucell Ordinary Shares and ADSs 5Johnson & Johnson Acquires 98.89% of Issued Crucell Shares as of the End of the Subsequent Offering Period and Crucell Intends to Delist Crucell Ordinary Shares and ADSs 6Johnson & Johnson Acquires 98.89% of Issued Crucell Shares as of the End of the Subsequent Offering Period and Crucell Intends to Delist Crucell Ordinary Shares and ADSs 7Cellceutix Reports Confidential Disclosure Agreement Signed With Major Pharmaceutical Company 2Cellceutix Reports Confidential Disclosure Agreement Signed With Major Pharmaceutical Company 3
... WH, the latest in the Magnes line of ... and its full cortical coverage, provides the highest ... allowing study of a wide range of neuronal ... choice of detector configurations and can be equipped ...
... a non-invasive and painless method of stimulating ... Laboratories manufactures two magnetic stimulation devices, the ... (HSMS). The Hight Speed MES-10 ... up to 25 Hz at full power. ...
... MOBEE headboxes are the ... line of portable battery-powered ... a robust new mechanical ... software, XLTEK's standard MOBEE24plus ...
The ACCU-Beam® line of Surgical Microscope Accessories includes digital camera adaptors, beam splitters, objective lenses, fiber optic cables, and fiberoptic retrofits....
Medicine Products: