Navigation Links
Reduction in antibody gene rearrangement in B cells related to type 1 diabetes, lupus
Date:12/23/2008

ains Prak. "Editing errors develop before B cells leave the bone marrow. However, treatments such as B-cell depletion might be less likely to work in patients with editing errors because the self-attacking B cells can be regenerated rapidly as they develop in the bone marrow."

The researchers found a way to look at the editing history of B cells in the human and mouse samples, by monitoring the frequency of a non-functional light chain genetic rearrangement in the B cell antibody, which is termed RS. The investigators surmise that a decrease in RS levels indicates that B cells that react with self can evade editing of their self-reactivity and that defects in editing, in turn, may lead to an increased risk of developing autoimmune disease.

The measurement of RS frequency is independent of antibody specificity and, because it is non-functional and irreversible, it can be used to monitor the level of antibody gene rearrangement in any B cell population and in any autoimmune disease. The team is now interested in testing if RS frequency is altered in other autoimmune diseases and if a low RS level in an apparently healthy person is predictive of future autoimmunity. The RS assay may also be of use to clinicians who treat patients with established autoimmunity and to researchers who are mapping genes that are associated with different underlying causes of autoimmunity.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Smaller breast reduction surgeries provide health benefits and should be reimbursed
2. ACM Helps Medicaid Programs Comply With Federal Deficit Reduction Act Mandates
3. Cancer researchers seek safe reduction of radiotherapy
4. Revisions to College Cost Reduction and Access Act will create barriers to primary care
5. UltraShape(TM) Non-Invasive Fat Reduction and Body Contouring Clinical Study Results Presented at American Society for Dermatologic Surgery Annual Meeting
6. First colonoscopy with removal of polyps linked to reduction in colon cancer death
7. Leukocyte reduction seen as significant advance in transfusion medicine
8. Growth Trend for Gerresheimer Continues Unabated - Debt Reduction
9. Stress reduction products and services that are effective and safe
10. New Report Identifies Health Disparities and Reduction Strategies
11. Photo: Beverly Hills Liposculpture Specializes in Scarless Breast Reduction Dr. Alan Bittner Reduces Female Breasts by up to 50%
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Reduction in antibody gene rearrangement in B cells related to type 1 diabetes, lupus
(Date:12/25/2014)... 25, 2014 Recently, LunaDress.co.uk has updated its blog ... related accessories. Now, all of the models at LunaDress.co.uk come with ... groom lifts the wedding veil can turn out to be a ... A wedding veil can always bring surprise to a wedding. On ... how to choose veils for a big day . , ...
(Date:12/25/2014)... Dec. 25, 2014 (HealthDay News) -- Overeating is common during ... eat in moderation, an expert says. "Don,t arrive at ... calories if you know you,ll be attending a party, but ... Ashbey-Pejoves, lead dietitian at Northern Westchester Hospital in Mount Kisco, ... to eat healthy during the day and even to have ...
(Date:12/25/2014)... tries its best to translate the experience of dress ... introduced its new collection of 2015 prom dresses, and ... prom outfits are guaranteed to contain the perfect designs ... designed for 2015. Anyone who wants to buy ... before Jan. 26, 2015, the deadline of the promotion. ...
(Date:12/25/2014)... Aliso Viejo, California (PRWEB) December 25, 2014 ... the release of ProFire 5k. A fully customizable business ... X . , “Adding the ProFire 5k business tool, ... style” Said Christina Austin, CEO of Pixel Film Studios. ... the look and style to add professionalism to a ...
(Date:12/25/2014)... Phoenix, AZ (PRWEB) December 25, 2014 ... comes to outstanding customer service and affordable quality regarding ... metropolitan area announces recognition in 2014 by the “Queen ... and Sons has earned an impressive reputation over the ... pricing on a wide range of contractor services for ...
Breaking Medicine News(10 mins):Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 3
... The research shows that in addition to the major ... to the immune cells, genetic factors, that control some ... The results could make it possible to prevent neuroinflammatory ... the vaccination in humans. This study has just been ...
... (October 10, 2011) John Theurer Cancer Center ... top 50 best hospitals for cancer, will host ... and Liquid Tumors on November 3-4 from 7:00am ... program will feature internationally recognized oncologists and hematologists ...
... more cases of tuberculosis worldwide over the next 40 years ... scenario predicted by a new study led by the University ... rates. Smoking raises the risk of contracting TB, said ... Once smokers develop the disease, they are more likely to ...
... for Radiation Oncology (ASTRO), the Association of Residents in ... 2011 Educator of the Year Award. , ARRO sponsors ... outstanding teachers and mentors of radiation oncology residents. Residents ... to select one faculty member from their program for ...
... Researchers with UCLA,s Jonsson Comprehensive Cancer Center have ... that identifies and characterizes chemical compounds that can ... creating deadly brain tumors. Glioblastoma is one ... 12 to 18 months. These brain cancers consist ...
... MONDAY, Oct. 10 (HealthDay News) -- In the latest research ... Swedish scientists report that eating chocolate seems to lower a ... women who had the highest consumption of chocolate -- about ... reduced risk of stroke. "Cocoa contains flavonoids, which have ...
Cached Medicine News:Health News:A safer vaccination for Alzheimer's disease? 2Health News:John Theurer Cancer Center hosts New Frontiers in the Management of Solid and Liquid Tumors 2Health News:John Theurer Cancer Center hosts New Frontiers in the Management of Solid and Liquid Tumors 3Health News:40 million TB deaths due to smoking over next 40 years 2Health News:ARRO honors 39 with Educator of the Year Award 2Health News:UCLA researchers develop new way to screen for brain cancer stem cell killers 2Health News:UCLA researchers develop new way to screen for brain cancer stem cell killers 3Health News:Chocolate Could Be Sweet Defense Against Stroke 2Health News:Chocolate Could Be Sweet Defense Against Stroke 3
(Date:12/24/2014)... 2014  Commonwealth Cornerstone Group (CCG) today announced the completion ... Tuesday to help fund the expansion and consolidation of healthcare ... Sharon . PHN is the largest ... . It is the largest employer in Sharon,s ... on staff. Currently, PHN Sharon offers scattered services ...
(Date:12/24/2014)... 2014  The International Trade Commission (ITC) issued its final ... Medical. In a notice issued on December 23, the ITC ... on its humidifier was invalid. BMC President, ... are very excited with the ITC,s decision in this case. ... taken since the very beginning on the key patents in ...
(Date:12/24/2014)... , December 24, 2014 ... at an average rate of 8.1%. The US has ... knee and spine surgeries are the common orthopedic procedures ... have a lower penetration. Increased number of product recalls ... Non-metallic orthopedic devices have gained popularity in the industry ...
Breaking Medicine Technology:Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 2Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 3ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3
... July 26, 2011 Perrigo Company (Nasdaq: PRGO;TASE) today ... Laboratories, Inc. ("Paddock"), a privately-held, Minneapolis-based pharmaceutical manufacturer of ... $540 million in cash. Perrigo Chairman ... pleased to welcome the Paddock team to the Perrigo ...
... Corporation (NYSE: CBM ) announced that second ... August 2, 2011 after the market closes. ... discuss the second quarter 2011 financial results.Second Quarter 2011 ... at 8:30 a.m. Eastern Time Dial-in: , 1-888-471-3840 ...
Cached Medicine Technology:Perrigo Closes Acquisition of Paddock Labs 2Perrigo Closes Acquisition of Paddock Labs 3
Cocoon Disposable Patient Warming Blankets are specially designed to prevent hypothermia and maintain normothermia in your patients. The soft warm coloured material is strong and resists tearing and ...
The upper body blanket covers the upper torso, arms, neck, and head of the patient....
The Electri-Cool® II is the premier choice when it comes to localized cold therapy systems. system offers the widest variety of application-specific pads and wraps, for your convenience....
Complete Cataract Competence , OPMI VISU 140 is compact, good and economical. It's everything a cataract specialist needs today....
Medicine Products: