Navigation Links
Reduction in antibody gene rearrangement in B cells related to type 1 diabetes, lupus
Date:12/23/2008

ains Prak. "Editing errors develop before B cells leave the bone marrow. However, treatments such as B-cell depletion might be less likely to work in patients with editing errors because the self-attacking B cells can be regenerated rapidly as they develop in the bone marrow."

The researchers found a way to look at the editing history of B cells in the human and mouse samples, by monitoring the frequency of a non-functional light chain genetic rearrangement in the B cell antibody, which is termed RS. The investigators surmise that a decrease in RS levels indicates that B cells that react with self can evade editing of their self-reactivity and that defects in editing, in turn, may lead to an increased risk of developing autoimmune disease.

The measurement of RS frequency is independent of antibody specificity and, because it is non-functional and irreversible, it can be used to monitor the level of antibody gene rearrangement in any B cell population and in any autoimmune disease. The team is now interested in testing if RS frequency is altered in other autoimmune diseases and if a low RS level in an apparently healthy person is predictive of future autoimmunity. The RS assay may also be of use to clinicians who treat patients with established autoimmunity and to researchers who are mapping genes that are associated with different underlying causes of autoimmunity.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Smaller breast reduction surgeries provide health benefits and should be reimbursed
2. ACM Helps Medicaid Programs Comply With Federal Deficit Reduction Act Mandates
3. Cancer researchers seek safe reduction of radiotherapy
4. Revisions to College Cost Reduction and Access Act will create barriers to primary care
5. UltraShape(TM) Non-Invasive Fat Reduction and Body Contouring Clinical Study Results Presented at American Society for Dermatologic Surgery Annual Meeting
6. First colonoscopy with removal of polyps linked to reduction in colon cancer death
7. Leukocyte reduction seen as significant advance in transfusion medicine
8. Growth Trend for Gerresheimer Continues Unabated - Debt Reduction
9. Stress reduction products and services that are effective and safe
10. New Report Identifies Health Disparities and Reduction Strategies
11. Photo: Beverly Hills Liposculpture Specializes in Scarless Breast Reduction Dr. Alan Bittner Reduces Female Breasts by up to 50%
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Reduction in antibody gene rearrangement in B cells related to type 1 diabetes, lupus
(Date:7/7/2015)... NY (PRWEB) , ... July 08, 2015 , ... ... honors Jennifer Call as a 2015-2016 inductee into its VIP Woman of the ... health. NAPW is the nation’s leading networking organization exclusively for professional women, boasting ...
(Date:7/7/2015)... Rockville, MD (PRWEB) , ... July 08, 2015 ... ... educational event designed to help today’s surgical services directors and business managers increase ... OR Manager, the conference will be held at the Renaissance Phoenix Glendale, February ...
(Date:7/7/2015)... ... July 08, 2015 , ... ... as a 2015-2016 inductee into its VIP Woman of the Year Circle. She ... the nation’s leading networking organization exclusively for professional women, boasting more than 700,000 ...
(Date:7/7/2015)... ... ... The National Association of Professional Women (NAPW) honors Alyssa ... She is recognized with this prestigious distinction for leadership in pharmacy. NAPW is the ... over 200 operating Local Chapters. , “I’m pleased to recognize Alyssa with this important ...
(Date:7/7/2015)... (PRWEB) , ... July 08, 2015 , ... ... Jessica Goldstein as a 2015-2016 inductee into its VIP Woman of ... business. NAPW is the nation’s leading networking organization exclusively for professional women, boasting ...
Breaking Medicine News(10 mins):Health News:National Association of Professional Women Inducts Jennifer Call, Clinical Director at Apex Behavior Consulting, Into its VIP Woman of the Year Circle 2Health News:Agenda, Pre-Conference Workshop, and More Announced for OR Business Management Conference 2Health News:Agenda, Pre-Conference Workshop, and More Announced for OR Business Management Conference 3Health News:National Association of Professional Women Inducts Brandy Emmons-Powell, Director of Quality Development at Didlake, Inc., Into its VIP Woman of the Year Circle 2Health News:National Association of Professional Women Inducts Brandy Emmons-Powell, Director of Quality Development at Didlake, Inc., Into its VIP Woman of the Year Circle 3Health News:National Association of Professional Women Inducts Dr. Alyssa Greedy, Pharm. D., Pharmacy Manager at Walgreens, Into its VIP Woman of the Year Circle 2Health News:National Association of Professional Women Inducts Jessica Goldstein, Vice President / Account Director at Discovery USA, Into its VIP Woman of the Year Circle 2
... But sites devoted to complementary or alternative medicine may ... 11 (HealthDay News) -- Just 5 percent of Web ... pages focused on complementary or alternative medicine are 15 ... other false information, a new study says. , Moreover, ...
... DC When the public considers competing arguments about a ... agree with the expert whose values are closest to their ... will hold true for nanotechnology, a key study has found. ... today by the Project on Emerging Nanotechnologies (PEN). The study ...
... ... - $352 Average Patient Charge (APC) ... - $13.9 Million EBITDA From Continuing Operations ... 2008 Guidance, SCOTTSDALE, Ariz., Feb. 11 Rural/Metro,Corporation (Nasdaq: RURL ), a leading provider ...
... National Insurers Bring Programs to the State, While ... According to a New Report from HealthLeaders-InterStudy, ... of managed care market intelligence, reports that pay-for-,performance ... According to the,latest Arizona Health Plan Analysis, the ...
... recent years, increasing attention,has been paid to the ... In some instances, proponents of LBA made,overly-optimistic claims ... predictor in,the underwriting process. Milliman expert Jonathan Shreve, ... effective use of Lifestyle-Based,Analytics as an advance in ...
... SAN JUAN, Puerto Rico, Feb. 11 Triple-S,Management Corporation ... in,Puerto Rico, today announced record consolidated operating income of ... $2.15 for the year ended,December 31, 2007 (including $0.07 ... Company,s strong market position and medical cost,management., ...
Cached Medicine News:Health News:Most Breast Cancer Web Pages Contain Reliable Information 2Health News:Nanotechnology's future depends on who the public trusts 2Health News:Rural/Metro Announces Results for Fiscal 2008 Second Quarter 2Health News:Rural/Metro Announces Results for Fiscal 2008 Second Quarter 3Health News:Rural/Metro Announces Results for Fiscal 2008 Second Quarter 4Health News:Rural/Metro Announces Results for Fiscal 2008 Second Quarter 5Health News:Rural/Metro Announces Results for Fiscal 2008 Second Quarter 6Health News:Rural/Metro Announces Results for Fiscal 2008 Second Quarter 7Health News:Rural/Metro Announces Results for Fiscal 2008 Second Quarter 8Health News:Rural/Metro Announces Results for Fiscal 2008 Second Quarter 9Health News:Rural/Metro Announces Results for Fiscal 2008 Second Quarter 10Health News:Rural/Metro Announces Results for Fiscal 2008 Second Quarter 11Health News:Rural/Metro Announces Results for Fiscal 2008 Second Quarter 12Health News:Rural/Metro Announces Results for Fiscal 2008 Second Quarter 13Health News:Rural/Metro Announces Results for Fiscal 2008 Second Quarter 14Health News:Rural/Metro Announces Results for Fiscal 2008 Second Quarter 15Health News:Pay-For-Performance Not Getting a Red-Carpet Reception in Arizona 2Health News:Milliman Expert Addresses Practical Applications of Lifestyle-Based Analytics in Risk Selection 2Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 2Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 3Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 4Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 5Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 6Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 7Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 8Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 9Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 10Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 11Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 12Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 13
(Date:7/7/2015)... , July 7, 2015  Shareholder rights ... that a federal securities fraud class action complaint ... the Southern District of California.  The complaint alleges ... CLDN ) violated the Securities Exchange Act ... 25, 2015, by making materially false and misleading ...
(Date:7/7/2015)... 7, 2015 Berger & Montague, P.C., ... law firm with one of the largest and ... co-counsel Faruqi and Faruqi, LLP in settling three ... AstraZeneca Pharmaceuticals LP, Cephalon, Inc., and Biogen, Inc., ... fees.  Under the agreements, AstraZeneca will pay the ...
(Date:7/7/2015)... Kalifornien, 7. Juli 2015 Sequent ... sich der Entwicklung innovativer Geräte für die ... Zugang von R. Michael Kleine ... Herr Kleine verfügt über eine mehr als ... Gesundheitsfürsorge. Er hat verschiedene globale biomedizinische Unternehmen ...
Breaking Medicine Technology:Robbins Arroyo LLP: Celladon Corporation (CLDN) Misled Shareholders According to a Recently Filed Class Action 2Robbins Arroyo LLP: Celladon Corporation (CLDN) Misled Shareholders According to a Recently Filed Class Action 3AstraZeneca, Cephalon, and Biogen Idec to Pay $55.5 Million to Resolve False Claims Act Allegations Made By Whistleblower Ronald Streck 2AstraZeneca, Cephalon, and Biogen Idec to Pay $55.5 Million to Resolve False Claims Act Allegations Made By Whistleblower Ronald Streck 3Sequent Medical beruft Mike Kleine in den Aufsichtsrat 2Sequent Medical beruft Mike Kleine in den Aufsichtsrat 3
... Clinical Therapeutic Cancer... -- TUEBINGEN, Germany, September 21, 2010 ... ... ... first_result; // Results are keyed by longUrl, so we need to grab the first one. for (var ...
... MOUNTAIN VIEW, Calif., Sept. 21 VIVUS, Inc. (Nasdaq: ... from a two-year study of QNEXA® (phentermine/topiramate) Controlled Release ... condition that affects approximately one-third of adult Americans. ... (OB-305), a 52-week extension study for a subset of ...
Cached Medicine Technology:immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 2immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 3immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 4immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 5immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 6immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 7immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 8immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 9immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 10New Long-Term Data on QNEXA® Show Significant and Sustained Weight Loss of Greater Than 10% Over Two Years 2New Long-Term Data on QNEXA® Show Significant and Sustained Weight Loss of Greater Than 10% Over Two Years 3New Long-Term Data on QNEXA® Show Significant and Sustained Weight Loss of Greater Than 10% Over Two Years 4New Long-Term Data on QNEXA® Show Significant and Sustained Weight Loss of Greater Than 10% Over Two Years 5New Long-Term Data on QNEXA® Show Significant and Sustained Weight Loss of Greater Than 10% Over Two Years 6
... system for performing fast, clean, safe and ... is microprocessor controlled to automatically spin CenSlide ... minute. At the end of the cycle, ... the viewing area for microscopic analysis.,The CenSlide ...
Used to provide drainage of urine from the bladder. All-silicone construction provides maximum softness and biocompatibility for enhanced patient comfort. Supplied sterile in peel-open packages. Inte...
... temporary internal drainage from the ... Supplied sterile in peel-open packages. ... Periodic evaluation is advised; polyurethane, ... not remain indwelling more than ...
... temporary internal drainage from ... the bladder in pediatric ... peel-open packages. Intended for ... evaluation is advised; stent ...
Medicine Products: