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Reducing intake of dietary fat prevents prostate cancer in mice
Date:5/14/2008

Scientists with UCLAs Jonsson Cancer Center and the Department of Urology have showed that lowering intake of the type of fat common in a Western diet helps prevent prostate cancer in mice, the first finding of its kind in a mouse model that closely mimics human cancer, researchers said.

The study, which appears in the April 15, 2008 issue of the journal Cancer Research, focused on fat from corn oil, which is made up primarily of omega-6 fatty acids, or the polyunsaturated fat commonly found in the Western diet. Omega-6 fats are found in high levels in baked and fried goods, said William Aronson, a Jonsson Cancer Center researcher and the studys senior author.

Researchers fed one group of mice a diet with about 40 percent of calories coming from fat, a percentage typical in men eating a Western diet. The other group received 12 percent of their calories from fat, a figure considered to be a very low fat diet. Researchers found there was a 27 percent reduced incidence of prostate cancer in the low-fat diet group. Aronson also studied cells in the prostate that were precancerous, or would soon become cancer, and found that the cells in the mice eating the low-fat diet were growing much more slowly than those in the high-fat group.

Previous studies in Aronsons lab showed that a low-fat diet slowed the growth of aggressive human prostate cancers in mice and helped the mice live longer. However, whether such a diet could prevent prostate cancer was unknown.

We didnt know what to expect in terms of the role of reducing dietary fat in preventing prostate cancer, said Aronson, a professor of urology. We think this is an important finding and we are presently performing further studies in animal models and conducting clinical trials in men.

Using a novel mouse model that develops cancer within the prostate over a period of six to nine months, Aronson and his team were able to study cancer incidence and cell growth. The
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Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

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