Navigation Links
Reducing intake of dietary fat prevents prostate cancer in mice
Date:5/14/2008

Scientists with UCLAs Jonsson Cancer Center and the Department of Urology have showed that lowering intake of the type of fat common in a Western diet helps prevent prostate cancer in mice, the first finding of its kind in a mouse model that closely mimics human cancer, researchers said.

The study, which appears in the April 15, 2008 issue of the journal Cancer Research, focused on fat from corn oil, which is made up primarily of omega-6 fatty acids, or the polyunsaturated fat commonly found in the Western diet. Omega-6 fats are found in high levels in baked and fried goods, said William Aronson, a Jonsson Cancer Center researcher and the studys senior author.

Researchers fed one group of mice a diet with about 40 percent of calories coming from fat, a percentage typical in men eating a Western diet. The other group received 12 percent of their calories from fat, a figure considered to be a very low fat diet. Researchers found there was a 27 percent reduced incidence of prostate cancer in the low-fat diet group. Aronson also studied cells in the prostate that were precancerous, or would soon become cancer, and found that the cells in the mice eating the low-fat diet were growing much more slowly than those in the high-fat group.

Previous studies in Aronsons lab showed that a low-fat diet slowed the growth of aggressive human prostate cancers in mice and helped the mice live longer. However, whether such a diet could prevent prostate cancer was unknown.

We didnt know what to expect in terms of the role of reducing dietary fat in preventing prostate cancer, said Aronson, a professor of urology. We think this is an important finding and we are presently performing further studies in animal models and conducting clinical trials in men.

Using a novel mouse model that develops cancer within the prostate over a period of six to nine months, Aronson and his team were able to study cancer incidence and cell growth. The mice were assigned to a dietary fat group at three weeks of age, when they first started ingesting food. The prostates and prostate cells were studied at seven months.

During the growth phase when the precancerous lesions develop, called PIN or prostate intraepithelial neoplasia, Aronson found that mice on the low-fat diet had higher levels of a protein in their bloodstreams that binds to insulin like growth factor, which spurs prostate cancer growth. Aronson believes that lowering dietary fat and increasing levels of the binding protein slows prostate cancer development by cutting off the growth factor that allows prostate cancer to thrive.

A low-fat, high-fiber diet combined with weight loss and exercise is well known to be healthy in terms of heart disease and is known to reduce the risk of heart attacks and strokes, so that would be a healthy choice to make, Aronson said. Whether or not it will prevent prostate cancer in humans remains to be seen.

Aronson is now conducting a short term study in men who are randomly assigned to a Western diet higher in polyunsaturated fat or a low-fat diet with fish oil supplements. The next step is to see how these diets affect malignant and benign human prostate tissue, Aronson said.

Were looking at specific markers and growth factors in human tissue known to be important for development and progression of prostate cancer, he said. Its this work we hope will lead to longer term prevention strategies incorporating dietary changes.


'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Related medicine news :

1. Shire investigational nonstimulant INTUNIV showed significant efficacy in reducing ADHD symptoms
2. Sacramento Chiropractor Takes Aim at Reducing Car Accident Injuries
3. Study shows physician judgement important in reducing RSV-related hospitalizations
4. Study Suggests Stronger Tobacco Control Policies in States With High Smoking Rates Would be Effective in Reducing Smoking and Saving Thousands of Lives
5. U of M study: Online intervention paramount for reducing HIV in high-risk population
6. EPA Recognizes Fort Wayne Community Schools for Reducing Diesel Emissions From Its School Buses
7. Joint Center Sees Social Determinants of Health as Key to Reducing Disparities at Annual Fund-raising Gala
8. Preliminary Data From Pitt County Memorial Hospital Study Show Benefit of Active Surveillance on Reducing MRSA VAP Rates in Surgical ICU
9. Astellas/GlaxoSmithKlines Vesicare Has Advantages Over Pfizers Detrol LA/Detrusitol XL in Reducing Episodes of Urge Urinary Incontinence
10. Reducing Cost of Health Care by Addressing Workers Compensation Costs
11. LG Electronics Debuts Unique Allergen-Reducing Steam Washer/Dryer Combo
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2016)... ... December 05, 2016 , ... U.S. Apple Association (USApple) ... part of the second annual Apples for Education: Buy an Apple, Help a ... providing healthy food for students to take home to their families; solar technology to ...
(Date:12/5/2016)... ... ... “Life Will Never Be The Same” is a fictional tale about growing up with ... is the creation of published author, Kim T. Briggs, a self-described “big kid” who ... religion and philosophy from Judson University in Elgin, Illinois. Having written numerous Christian drama ...
(Date:12/5/2016)... ... 2016 , ... The new knee compression sleeves come as a pair which ... sleeves for lifting and any sport that requires knee compression or protection from ... provide a higher quality knee sleeve performance. Firstly it is made out of premium ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... that they have teamed up with The American College of Surgeons (ACS) to ... Committee on Trauma, the “Bleeding Control Basic” course is a pilot program that ...
(Date:12/4/2016)... ... December 03, 2016 , ... ... transitions and many more tools allowing FCPX editors to create professional looking video ... Studios. , Perfect Harmony contains a beautifully designed 3D environment for placing ...
Breaking Medicine News(10 mins):
(Date:12/4/2016)... 3, 2016 Johnson & Weaver, LLP announces that ... of Zimmer Biomet Holdings, Inc. (NYSE: ZBH ) ... 31, 2016 (the "Class Period"). Zimmer Biomet provides ... orthopaedic reconstructive products, such as knee and hip reconstructive products. ... , , ...
(Date:12/4/2016)... , Dec. 3, 2016  Results from the ... SelG1), an anti-P-selectin antibody, reduced the median annual rate ... to placebo (1.63 vs 2.98, p=0.010) in patients with ... that the data are being featured in the official ... of Hematology (ASH) Annual Meeting and presented during the ...
(Date:12/2/2016)... SPRING, Md. , Dec. 2, 2016 ... new indication for Jardiance (empagliflozin) to reduce the risk ... diabetes mellitus and cardiovascular disease. "Cardiovascular ... with type 2 diabetes mellitus," said Jean-Marc Guettier ... and Endocrinology Products in FDA,s Center for Drug Evaluation ...
Breaking Medicine Technology: