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Reduced kidney function associated with higher risk of renal and urothelial cancer
Date:5/29/2014

SALT LAKE CITY Researchers who investigated the level of kidney function and subsequent cancer risk in more than one million adults have found that reduced glomerular filtration rate (GFR) a key measure of reduced kidney function and chronic kidney disease (CKD) is an independent risk factor for renal and urothelial cancer but not other cancer types.

The retrospective study of almost 1.2 million adult members of the Kaiser Permanente healthcare system was conducted by the Kaiser Permanente Division of Research, the University of Utah's Huntsman Cancer Institute and Memorial Sloan Kettering Cancer Center, and published online today in the Journal of the American Society of Nephrology.

Chronic kidney disease and cancer are both major and growing public health problems. The incidence of chronic kidney disease continues to rise, with an estimated 11.5 percent of the U.S. population having reduced glomerular filtration rate, and approximately 13.5 million Americans with stage 3 or worse chronic kidney disease.

"While multiple studies have observed higher risks of cancer in persons with end-stage renal disease, the association of less severe kidney disease with cancer remains poorly understood," said lead author William Lowrance, MD, MPH, investigator at the University of Utah's Huntsman Cancer Institute. "These findings address that knowledge gap."

Investigators studied 1,190,538 adults aged 40 years and older with known kidney function and no history of cancer, dialysis or renal transplantation. Median follow-up of the cohort between 2000 and 2008 was 5.3 years. At their entry point to the study, patients with lower GFR were more likely to be older, be persons of color, be current or former smokers, have lower socioeconomic status, and have a higher burden of comorbidity.

During follow-up, a total of 76,809 incident cancers were documented among 72,875 subjects (38,744 men and 34,131 women). Compared with GFR (
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Contact: Linda Aagard
linda.aagard@hci.utah.edu
801-587-7639
University of Utah Health Sciences
Source:Eurekalert

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