Navigation Links
Reduced kidney function associated with higher risk of renal and urothelial cancer
Date:5/29/2014

SALT LAKE CITY Researchers who investigated the level of kidney function and subsequent cancer risk in more than one million adults have found that reduced glomerular filtration rate (GFR) a key measure of reduced kidney function and chronic kidney disease (CKD) is an independent risk factor for renal and urothelial cancer but not other cancer types.

The retrospective study of almost 1.2 million adult members of the Kaiser Permanente healthcare system was conducted by the Kaiser Permanente Division of Research, the University of Utah's Huntsman Cancer Institute and Memorial Sloan Kettering Cancer Center, and published online today in the Journal of the American Society of Nephrology.

Chronic kidney disease and cancer are both major and growing public health problems. The incidence of chronic kidney disease continues to rise, with an estimated 11.5 percent of the U.S. population having reduced glomerular filtration rate, and approximately 13.5 million Americans with stage 3 or worse chronic kidney disease.

"While multiple studies have observed higher risks of cancer in persons with end-stage renal disease, the association of less severe kidney disease with cancer remains poorly understood," said lead author William Lowrance, MD, MPH, investigator at the University of Utah's Huntsman Cancer Institute. "These findings address that knowledge gap."

Investigators studied 1,190,538 adults aged 40 years and older with known kidney function and no history of cancer, dialysis or renal transplantation. Median follow-up of the cohort between 2000 and 2008 was 5.3 years. At their entry point to the study, patients with lower GFR were more likely to be older, be persons of color, be current or former smokers, have lower socioeconomic status, and have a higher burden of comorbidity.

During follow-up, a total of 76,809 incident cancers were documented among 72,875 subjects (38,744 men and 34,131 women). Compared with GFR (in ml/min/1.73 m2) of 60 to 89, there was an increased rate of incident renal cancer, ranging from a 39 percent increased rate for GFR of 45 to 59 to a more than two-fold increased rate for GFR less than 30. This increased rate was of greater magnitude for clear cell renal cancer as compared with non-clear cell renal cancer.

Compared with GFR of 60 to 89, researchers also found that GFR less than 30 was associated with a 48 percent increased rate of urothelial cancer. However, GFR levels below 60 were not significantly associated with prostate, colorectal, lung, breast or any cancer.

The researchers say several possible biologic mechanisms may help to explain the association between level of kidney function and renal or urothelial cancers. Kidney dysfunction results in a state of chronic inflammation and oxidative stress, and such an inflammatory microenvironment may play a role in cancer development. Severe chronic kidney disease may additionally create a relative state of immunodeficiency, which could influence the development of cancer.

"These and other mechanisms deserve further study in order to better define the link between kidney function and site-specific cancer risk," said Paul Russo, MD, FACS, study co-author and urologic surgeon at Memorial Sloan Kettering. "The stronger association of GFR and clear cell renal cancer as compared with non-clear cell provides new insights into the biologic underpinnings of the association of chronic kidney disease and renal cancer."

As for the clinical implications of the findings, Juan Ordonez, MD, study co-author and Chair of the Chiefs of Nephrology for Kaiser Permanente Northern California, said, "If GFR is associated with an increased risk of renal and urothelial cancer, then it could have implications for directing cancer screening efforts in select populations. Currently, there are no evidence-based cancer screening recommendations tailored for patients with chronic kidney disease. Additional studies are needed to clarify the reasons for this association and help us assess the potential advantage of targeted cancer screening in patients with chronic kidney disease."


'/>"/>

Contact: Linda Aagard
linda.aagard@hci.utah.edu
801-587-7639
University of Utah Health Sciences
Source:Eurekalert

Related medicine news :

1. Huntingtons Disease Linked to Reduced Cancer Risk in Study
2. Decision guide reduced uncertainty over breast cancer prevention, study finds
3. Physical activity linked to reduced mortality in breast and colon cancer patients
4. High-contrast, high-resolution CT scans now possible at reduced dose
5. Long-term testosterone treatment for men results in reduced weight and waist size
6. HCOs find risks & opportunities in quest for reduced costs & improved quality
7. Health care organizations quest for reduced costs and improved quality
8. PharmaNet system dramatically reduced inappropriate prescriptions of potentially addictive drugs
9. Study shows anaesthetic-related deaths reduced dramatically
10. Health inequalities could be reduced by more effective healthcare, says new study
11. Health inequalities could be reduced by more effective health care, says new study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... Arizona (PRWEB) , ... December 07, 2016 , ... Delete® ... Just in Time For The Holiday Party Season. Save Up To 33% Off Botox® ... Laser Salon is providing the Phoenix Valley with Delightful Deals on Botox® ...
(Date:12/7/2016)... , ... December 07, 2016 , ... "ProBrand Flip allows ... all media," said Christina Austin - CEO of Pixel Film Studios. , ProBrand Flip ... to use drop zones. Editors can select from a variety of flip book animations. ...
(Date:12/7/2016)... ... December 07, 2016 , ... “The Road To Restoration”: an ... not a one hour a week showing of hands. “The Road To Restoration” is ... “Perhaps you are familiar with the brass ring that you could reach out for, ...
(Date:12/7/2016)... , ... (PRWEB) December 07, 2016 , ... ... nonprofit for individuals impacted by cerebral cavernous angiomas, was awarded a grant from ... a patient engagement program. New Mexico has more people with cavernous angioma than ...
(Date:12/7/2016)... Warwick, New York (PRWEB) , ... December 07, 2016 , ... ... computer professor at Yale had described him as 'a genius.'" Thus begins "Margaret in ... R. L. Rhyse and published by Wyston Books, Inc. These novels narrate ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... 6, 2016 Homozygous Familial Hypercholesterolemia ... Summary Global Markets Direct,s latest Pharmaceutical ... Hypercholesterolemia (HoFH) – Pipeline Review, H2 2016, ... Hypercholesterolemia (HoFH) (Metabolic Disorders) pipeline landscape. ... which is caused due to mutation from ...
(Date:12/6/2016)... Dec. 6, 2016 Human Vaccines Market: ... region wise and country wise analysis of the ... manufacturers of human vaccines products, raw material suppliers, ... enter the market. The report provides qualitative ... market. Qualitative analysis comprises market dynamics, trends, product ...
(Date:12/6/2016)...  Nearly 30 million people in the ... diabetes. 1 However, nearly 40% of diabetes patients ... and significant glucose variability. 2 These patients are at ... If left untreated, hyperglycemia can lead to cardiovascular disease, ... 3 As part of Diabetes Awareness ...
Breaking Medicine Technology: